Electrophysiology in the age of light

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Two-Photon Laser Scanning Fluorescence Microscopy

1990 • 9,129 citations

Millisecond-timescale, genetically targeted optical control of neural activity

2005 • 4,621 citations

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

1997 • 3,163 citations

Far-Field Optical Nanoscopy

2007 • 2,876 citations

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

2003 • 2,582 citations

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

1998 • 2,538 citations

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

2009 • 2,502 citations

Single-channel currents recorded from membrane of denervated frog muscle fibres

1976 • 2,456 citations

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

2009 • 1,916 citations

Multimodal fast optical interrogation of neural circuitry

2007 • 1,727 citations

Dynamics of Ongoing Activity: Explanation of the Large Variability in Evoked Cortical Responses

1996 • 1,714 citations

Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons

2001 • 1,523 citations

Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo

2003 • 1,312 citations

In vivo two-photon calcium imaging of neuronal networks

2003 • 1,292 citations

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

2009 • 1,220 citations

Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex

2005 • 1,209 citations

Structure and Function of Dendritic Spines

2002 • 1,191 citations

Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile Mice

2007 • 1,114 citations

The subcellular organization of neocortical excitatory connections

2009 • 1,020 citations

Voltage clamp analysis of acetylcholine produced end‐plate current fluctuations at frog neuromuscular junction

1973 • 992 citations

Iso-orientation domains in cat visual cortex are arranged in pinwheel-like patterns

1991 • 859 citations

Localization of a Stable Neural Correlate of Associative Memory

2007 • 801 citations

Genetic Dissection of Neural Circuits

2008 • 768 citations

Linking Spontaneous Activity of Single Cortical Neurons and the Underlying Functional Architecture

1999 • 752 citations

The Life Cycle of Ca2+ Ions in Dendritic Spines

2002 • 741 citations

Temporally precise in vivo control of intracellular signalling

2009 • 695 citations

Photon Upmanship: Why Multiphoton Imaging Is More than a Gimmick

1997 • 674 citations

Two-photon imaging to a depth of 1000 µm in living brains by use of a Ti:Al_2O_3 regenerative amplifier

2003 • 634 citations

Excitatory cortical neurons form fine-scale functional networks

2005 • 633 citations

Circuit-breakers: optical technologies for probing neural signals and systems

2007 • 620 citations

VSDI: a new era in functional imaging of cortical dynamics

2004 • 615 citations

Action Potentials Recorded from Inside a Nerve Fibre

1939 • 615 citations

Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution

2007 • 605 citations

Bi-stable neural state switches

2008 • 604 citations

A Miniature Head-Mounted Two-Photon Microscope

2001 • 599 citations

Compartmentalized dendritic plasticity and input feature storage in neurons

2008 • 593 citations

Local Origin of Field Potentials in Visual Cortex

2009 • 564 citations

Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons

2005 • 562 citations

Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice

2007 • 550 citations

Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin

2005 • 537 citations

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

2008 • 511 citations

A genetically encoded calcium indicator for chronic in vivo two-photon imaging

2008 • 474 citations

Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy

1999 • 466 citations

Visualizing the Cortical Representation of Whisker Touch: Voltage-Sensitive Dye Imaging in Freely Moving Mice

2006 • 463 citations

Imaging exocytosis and endocytosis

1996 • 451 citations

Routing of spike series by dynamic circuits in the hippocampus

2004 • 435 citations

A Genetically Encoded Optical Probe of Membrane Voltage

1997 • 424 citations

Population imaging of ongoing neuronal activity in the visual cortex of awake rats

2008 • 422 citations

High-speed, miniaturized fluorescence microscopy in freely moving mice

2008 • 387 citations

Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors

2005 • 383 citations

Imaging cellular network dynamics in three dimensions using fast 3D laser scanning

2006 • 367 citations

Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo

2007 • 342 citations

Three-dimensional random access multiphoton microscopy for functional imaging of neuronal activity

2008 • 341 citations

Remote Control of Neuronal Activity with a Light-Gated Glutamate Receptor

2007 • 322 citations

Mechanisms of Calcium Influx into Hippocampal Spines: Heterogeneity among Spines, Coincidence Detection by NMDA Receptors, and Optical Quantal Analysis

1999 • 294 citations

Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters

2008 • 293 citations

Individual Single-Walled Carbon Nanotubes as Nanoelectrodes for Electrochemistry

2004 • 291 citations

Genetically Encoded Calcium Indicators

2008 • 283 citations

Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel

1999 • 276 citations

Advances in Light Microscopy for Neuroscience

2009 • 272 citations

Analysis of calcium channels in single spines using optical fluctuation analysis

2000 • 268 citations

Whole-Cell Recordings in Freely Moving Rats

2006 • 263 citations

Noninvasive detection of changes in membrane potential in cultured neurons by light scattering.

1991 • 260 citations

Genetically Encoded Indicators of Cellular Calcium Dynamics Based on Troponin C and Green Fluorescent Protein

2004 • 250 citations

Spike Inference from Calcium Imaging Using Sequential Monte Carlo Methods

2009 • 241 citations

GABAergic Neurons Are Less Selective to Stimulus Orientation than Excitatory Neurons in Layer II/III of Visual Cortex, as Revealed byIn VivoFunctional Ca²⁺Imaging in Transgenic Mice

2007 • 232 citations

Targeted Whole-Cell Recordings in the Mammalian Brain In Vivo

2003 • 221 citations

Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor

2008 • 196 citations

High-ResolutionIn VivoImaging of Hippocampal Dendrites and Spines

2004 • 181 citations

A hybrid approach to measuring electrical activity in genetically specified neurons

2005 • 177 citations

Imaging membrane potential in dendritic spines

2006 • 177 citations

Combined Voltage and Calcium Epifluorescence Imaging In Vitro and In Vivo Reveals Subthreshold and Suprathreshold Dynamics of Mouse Barrel Cortex

2007 • 175 citations

3D structural imaging of the brain with photons and electrons

2008 • 167 citations

Optical recording of action potentials from vertebrate nerve terminals using potentiometric probes provides evidence for sodium and calcium components

1983 • 165 citations

Optical Recording of Action Potentials with Second-Harmonic Generation Microscopy

2004 • 162 citations

Light-Driven Activation of β₂-Adrenergic Receptor Signaling by a Chimeric Rhodopsin Containing the β₂-Adrenergic Receptor Cytoplasmic Loops

2005 • 158 citations

Techniques for extracting single-trial activity patterns from large-scale neural recordings

2007 • 157 citations

Visual Receptive Field Structure of Cortical Inhibitory Neurons Revealed by Two-Photon Imaging Guided Recording

2009 • 156 citations

Characterization and Subcellular Targeting of GCaMP-Type Genetically-Encoded Calcium Indicators

2008 • 154 citations

Membrane Potential Changes in Dendritic Spines during Action Potentials and Synaptic Input

2009 • 146 citations

Fabrication and Characterization of Nanopore-Based Electrodes with Radii down to 2 nm

2005 • 129 citations

Voltage Imaging from Dendrites of Mitral Cells: EPSP Attenuation and Spike Trigger Zones

2004 • 128 citations

Advances in the speed and resolution of light microscopy

2008 • 125 citations

Optical probing of neuronal circuits with calcium indicators

2000 • 111 citations

Structural rearrangements in single ion channels detected optically in living cells

2002 • 105 citations

Submillisecond Optical Reporting of Membrane PotentialIn SituUsing a Neuronal Tracer Dye

2009 • 93 citations

Subcellular Topography of Visually Driven Dendritic Activity in the Vertebrate Visual System

2009 • 80 citations

All My Circuits: Using Multiple Electrodes to Understand Functioning Neural Networks

2008 • 74 citations

Three Levels of Neuroelectronic Interfacing

2006 • 72 citations

Effect of Voltage Sensitive Fluorescent Proteins on Neuronal Excitability

2009 • 67 citations

Optical Recording of Action Potentials and Other Discrete Physiological Events: A Perspective from Signal Detection Theory

2007 • 60 citations

Fabrication of nanoelectrodes for neurophysiology: cathodic electrophoretic paint insulation and focused ion beam milling

2005 • 33 citations

Drawing a spark from darkness: John Walsh and electric fish

2002 • 32 citations

Reverse optical probing (ROPING) of neocortical circuits

2006 • 18 citations

An ultra small array of electrodes for stimulating multiple inputs into a single neuron

2003 • 14 citations