Circuit-breakers: optical technologies for probing neural signals and systems

Genome-wide atlas of gene expression in the adult mouse brain

2006 • 5,374 citations

Millisecond-timescale, genetically targeted optical control of neural activity

2005 • 4,621 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Deep Brain Stimulation for Treatment-Resistant Depression

2005 • 3,877 citations

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

2003 • 2,582 citations

Multimodal fast optical interrogation of neural circuitry

2007 • 1,727 citations

Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons

2007 • 1,145 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

2007 • 1,028 citations

Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses

2005 • 978 citations

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

2007 • 968 citations

An optical neural interface:in vivocontrol of rodent motor cortex with integrated fiberoptic and optogenetic technology

2007 • 942 citations

Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia

2003 • 931 citations

Channelrhodopsin-2–assisted circuit mapping of long-range callosal projections

2007 • 928 citations

In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2

2007 • 761 citations

Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration

2006 • 729 citations

Channelrhodopsin-2 and optical control of excitable cells

2006 • 699 citations

Retrograde neuronal tracing with a deletion-mutant rabies virus

2006 • 660 citations

Experimental models of Parkinson's disease

2001 • 617 citations

Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution

2007 • 605 citations

Light-Induced Activation of Distinct Modulatory Neurons Triggers Appetitive or Aversive Learning in Drosophila Larvae

2006 • 592 citations

Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons

2005 • 562 citations

Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin

2005 • 537 citations

Two rhodopsins mediate phototaxis to low- and high-intensity light in Chlamydomonas reinhardtii

2002 • 529 citations

Visualizing the Cortical Representation of Whisker Touch: Voltage-Sensitive Dye Imaging in Freely Moving Mice

2006 • 463 citations

High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice

2007 • 381 citations

High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression

2007 • 375 citations

Kinetic evaluation of photosensitivity in genetically engineered neurons expressing green algae light-gated channels

2005 • 373 citations

Drug Targeting to the Brain

2006 • 333 citations

Remote Control of Neuronal Activity with a Light-Gated Glutamate Receptor

2007 • 322 citations

Viral vectors for gene delivery to the nervous system

2003 • 321 citations

Stereotaxic gene delivery in the rodent brain

2006 • 309 citations

Comparative Analysis of Adeno-Associated Viral Vector Serotypes 1, 2, 5, 7, And 8 in Mouse Brain

2007 • 295 citations

A functional neuroimaging investigation of deep brain stimulation in patients with obsessive–compulsive disorder

2006 • 259 citations

GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia

2000 • 257 citations

In Vivo Two-Photon Imaging Reveals a Role of Arc in Enhancing Orientation Specificity in Visual Cortex

2006 • 235 citations

Alteration of Neuronal Firing Properties afterIn VivoExperience in a FosGFP Transgenic Mouse

2004 • 234 citations

Physiological Properties of Hypothalamic MCH Neurons Identified with Selective Expression of Reporter Gene after Recombinant Virus Infection

2004 • 228 citations

GABA Transporter-1 mRNA in the Prefrontal Cortex in Schizophrenia: Decreased Expression in a Subset of Neurons

2001 • 222 citations

Motor cortex stimulation for long-term relief of chronic neuropathic pain: A 10 year experience

2006 • 188 citations

Reversible Silencing of Neuronal Excitability in Behaving Mice by a Genetically Targeted, Ivermectin-Gated Cl− Channel

2007 • 166 citations

Archaeal-type rhodopsins in Chlamydomonas: model structure and intracellular localization

2003 • 161 citations

Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirror

2006 • 150 citations

OPTICAL IMAGING AND CONTROL OF GENETICALLY DESIGNATED NEURONS IN FUNCTIONING CIRCUITS

2005 • 136 citations

Selective and Quickly Reversible Inactivation of Mammalian Neurons In Vivo Using the Drosophila Allatostatin Receptor

2006 • 136 citations

Genetically encoded Ca²⁺ indicators: using genetics and molecular design to understand complex physiology

2006 • 128 citations

Rapid and Reversible Chemical Inactivation of Synaptic Transmission in Genetically Targeted Neurons

2005 • 98 citations

Halobacterium pharaonis sp. nov., a New, Extremely Haloalkaliphilic Archaebacterium with Low Magnesium Requirement

1982 • 90 citations

Viral Vectors: A Wide Range of Choices and High Levels of Service

2007 • 52 citations

Directing neuron-specific transgene expression in the mouse CNS

2006 • 48 citations

Identification of cell-type-specific promoters within the brain using lentiviral vectors

2007 • 38 citations

A 12-Month Prospective Study of Gasserian Ganglion Stimulation for Trigeminal Neuropathic Pain

2007 • 32 citations

Mouse Molecular Genetic Technologies

2001 • 26 citations