Activation of TGF‐β within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

2002 • 1,572 citations

TGF-β and epithelial-to-mesenchymal transitions

2005 • 1,508 citations

New insights into TGF-β–Smad signalling

2004 • 1,169 citations

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

2002 • 866 citations

Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition

2007 • 799 citations

Roles of TGF-beta in hepatic fibrosis

2002 • 794 citations

Role of Transforming Growth Factor Beta in Human Cancer

2005 • 703 citations

Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets

2006 • 697 citations

All in the CCN family: essential matricellular signaling modulators emerge from the bunker

2006 • 640 citations

Circulating fibrocytes: collagen-secreting cells of the peripheral blood

2003 • 526 citations

Connective Tissue Growth Factor: What's in a Name?

2000 • 483 citations

Expression of MMPs and TIMPs in liver fibrosis – a systematic review with special emphasis on anti-fibrotic strategies

2007 • 472 citations

TGF-β and cancer

2005 • 463 citations

Emerging insights into Transforming growth factor Smad signal in hepatic fibrogenesis

2007 • 435 citations

Transforming growth factor β and the liver

2001 • 340 citations

Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro

2007 • 338 citations

TGF-β: from latent to active

1999 • 329 citations

Latency, activation, and binding proteins of TGF-?

2001 • 262 citations

The synthesis of proteoglycans in fat-storing cells of rat liver

1987 • 259 citations

TAp63α induces apoptosis by activating signaling via death receptors and mitochondria

2005 • 241 citations

TGF‐β control of cell proliferation

2005 • 221 citations

Effect of transforming growth factor beta on cell death of cultured rat hepatocytes.

1991 • 166 citations

Tissue inhibitors of metalloproteinases in liver fibrosis

1997 • 166 citations

Proliferating Bile Duct Epithelial Cells Are a Major Source of Connective Tissue Growth Factor in Rat Biliary Fibrosis

2001 • 148 citations

Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis

2004 • 148 citations

Differential effects of TGF-β on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes

2007 • 142 citations

An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.

1991 • 139 citations

Id1 is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate cells

2006 • 130 citations

Smad3 and Extracellular Signal-Regulated Kinase 1/2 Coordinately Mediate Transforming Growth Factor-β-Induced Expression of Connective Tissue Growth Factor in Human Fibroblasts

2005 • 118 citations

Peribiliary myofibroblasts in biliary type liver fibrosis

2002 • 116 citations

Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells

2001 • 113 citations

EMT or apoptosis: a decision for TGF-β

2007 • 112 citations

Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants

2003 • 108 citations

TGF-β1: immunosuppressant and viability factor for T lymphocytes

1999 • 105 citations

Profibrogenic transforming growth factor-β/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes

2007 • 102 citations

Processing of Immunosuppressive Pro-TGF-β1,2 by Human Glioblastoma Cells Involves Cytoplasmic and Secreted Furin-Like Proteases

2001 • 96 citations

TGF-β-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes

1997 • 93 citations

Modulation of the TGFβ/Smad signaling pathway in mesangial cells by CTGF/CCN2

2005 • 91 citations

Induction of the mitochondrial permeability transition by protease activity in rats: A mechanism of hepatocyte necrosis

1996 • 88 citations

Localization of transforming growth factor-beta 1 in mitochondria of murine heart and liver.

1991 • 86 citations

Involvement of Calpain in Integrin-Mediated Signal Transduction

1996 • 83 citations

Cell-associated activation of latent transforming growth factor-β by calpain

1998 • 81 citations

Calpain: a death protein that mediates progression of liver injury

2005 • 80 citations

Biology of transforming growth factor ? in hepatocarcinogenesis

2001 • 78 citations

(Latent) transforming growth factor ? in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells

1998 • 71 citations

Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor ?

1996 • 68 citations

Hyaluronic acid synthesis and secretion by rat liver fat storing cells (perisinusoidal lipocytes) in culture

1988 • 67 citations

Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection.

1996 • 61 citations

Loss of integrin linked kinase from mouse hepatocytesin vitro andin vivo results in apoptosis and hepatitis

2007 • 58 citations

Transforming growth factor β (TGF-β) expression in isolated and cultured rat hepatocytes

1996 • 57 citations

Regulation of hyaluronate synthesis in rat liver fat storing cell cultures by Kupffer cells

1988 • 55 citations

Regulation of Proteoglycan Expression in Fibrotic Liver and Cultured Fat-Storing Cells

1994 • 54 citations

Attenuation of TGF-β-Induced Apoptosis in Primary Cultures of Hepatocytes by Calpain Inhibitors

1997 • 44 citations

Subcellular localization of (latent) transforming growth factor β and the latent TGF-β binding protein in rat hepatocytes and hepatic stellate cells

1998 • 43 citations

Disruption of Transforming Growth Factor β Signaling by a Novel Ligand-dependent Mechanism

2002 • 41 citations

Fibrogenesis and type I collagen gene regulation.

1994 • 40 citations

A cascade of degradative hydrolase activity contributes to hepatocyte necrosis during anoxia

1996 • 33 citations

Preventive Effects of Acute Inflammation on Liver Cell Necrosis and Inhibition of Heparan Sulphate Synthesis in Hepatocytes

1986 • 31 citations

Expression and release of the latent transforming growth factor ? binding protein by hepatocytes from rat liver

1997 • 26 citations

Variation of immunocytochemical expression of transforming growth factor (TGF)-β in hepatocytes in culture and liver slices

1996 • 22 citations

EMT or apoptosis： a decision for TGF-β

2007 • 15 citations

Intracellular Cyclic Nucleotide Analogues Inhibit in vitro Mitogenesis and Activation of Fibroblasts Derived from Obstructed Rat Kidneys

2004 • 15 citations

A New Approach to an Unbiased Estimate of the Hepatic Stellate Cell Index in the Rat Liver: An Example in Healthy Conditions1

2003 • 11 citations

Tgf-β and the Smad Pathway in Liver Fibrogenesis

2005 • 4 citations

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