Transforming growth factor β (TGF-β) expression in isolated and cultured rat hepatocytes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

Engineering Cell Shape and Function

1994 • 1,447 citations

Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters.

1966 • 1,150 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Transforming Growth Factors β1 and α in Chronic Liver Disease

1991 • 655 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

1988 • 534 citations

Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation.

1988 • 483 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation.

1995 • 414 citations

Transforming growth factors and the regulation of cell proliferation

1990 • 390 citations

Characterization of differentiated and dedifferentiated clones from a rat hepatoma

1975 • 381 citations

Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis.

1990 • 354 citations

Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells

1995 • 348 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution.

1990 • 311 citations

Transforming growth factor β: a matter of life and death

1994 • 306 citations

Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis

1990 • 295 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

5462925 Transforming growth factor beta2,3

1996 • 255 citations

A role for TGF-beta in oligodendrocyte differentiation.

1993 • 253 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis.

1992 • 230 citations

Transforming growth factor—beta 1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers

1995 • 219 citations

Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins.

1991 • 216 citations

The primary structure of rat ribosomal protein S6.

1988 • 210 citations

Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion.

1987 • 184 citations

Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis

1993 • 173 citations

Hypoxia-ischemia induces transforming growth factor β1 mRNA in the infant rat brain

1992 • 173 citations

Effect of transforming growth factor beta on cell death of cultured rat hepatocytes.

1991 • 166 citations

Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts

1993 • 154 citations

Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.

1990 • 144 citations

Regulation of TGFβ gene expression in rat liver intoxicated with carbon tetrachloride

1990 • 137 citations

Increased transforming growth factor-β1 gene expression in human liver disease

1992 • 132 citations

Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration.

1991 • 113 citations

Immunohistochemical detection of transforming growth factor-β1 in fibrotic liver diseases

1991 • 111 citations

Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type β1 and type α

1990 • 103 citations

The Tumor-Promoting Effect of Wounding: A Possible Role for TGF-β-lnduced Stromal Alterations

1994 • 100 citations

Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital

1994 • 99 citations

Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis.

1995 • 94 citations

Biglycan and decorin gene expression in normal and fibrotic rat liver: Cellular localization and regulatory factors

1992 • 91 citations

Liver tumor promotion: Effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-?1 expression

1991 • 89 citations

Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat.

1990 • 81 citations

Identification and activation of latent transforming growth factor β

1991 • 72 citations

Identification and partial characterization of a hepatocyte-derived factor promoting proliferation of cultured fat-storing cells (parasinusoidal lipocytes)

1992 • 67 citations

Alpha 2-macroglobulin and serum preferentially counteract the mitoinhibitory effect of transforming growth factor-beta 2 in rat hepatocytes.

1990 • 64 citations

Vascular smooth muscle biglycan represents a highly conserved proteoglycan within the arterial wall.

1990 • 58 citations

Quantitative analysis of transforming growth factor β1 messenger RNA in the liver of patients with chronic hepatitis C: Absence of correlation between high levels and severity of disease

1995 • 57 citations

Synergism between hepatocytes and Kupffer cells in the activation of fat storing cells (perisinusoidal lipocytes)

1993 • 47 citations

Oxygen regulation of TGF-beta 1 mRNA in human hepatoma (Hep G2) cells.

1994 • 38 citations

Gene expression of transforming growth factor β1 and extracellular matrix proteins in murine Schistosoma mansoni infection

1994 • 36 citations

TGF-β receptors: a complicated system of multiple binding proteins

1993 • 32 citations

cDNA sequence for rat dermatan sulfate proteoglycan-II (decorin)

1992 • 28 citations

Endothelial cell stimulation of smooth muscle glycosaminoglycan synthesis can be accounted for by transforming growth factor beta activity

1990 • 23 citations

IV liver cancer

1995 • 20 citations

An experimental study in the use of instrumentation to analyze metabolism and product formation in cell culture

1982 • 15 citations