2 Endothelial cell proteases: Physiological role and regulation

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

1987 • 1,516 citations

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

1982 • 1,300 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

1990 • 428 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

1988 • 354 citations

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

1983 • 345 citations

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

1986 • 343 citations

Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1.

1986 • 325 citations

Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes

1991 • 307 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

Plasminogen Activator Inhibitors - A Review

1988 • 299 citations

Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells.

1987 • 286 citations

Plasminogen activator and collagenase production by cultured capillary endothelial cells

1982 • 279 citations

Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.

1990 • 272 citations

Thrombosis and haemostasis

1988 • 263 citations

Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase

1989 • 233 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane

1982 • 226 citations

Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components

1983 • 222 citations

8 Growth Factor-Regulated Proteases and Extracellular Matrix Remodeling during Mammalian Development

1990 • 219 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity.

1986 • 215 citations

Ras oncogene mediated induction of a 92kDa metalloproteinase; strong correlation with the malignant phenotype

1988 • 209 citations

Activation of plasminogen by pro-urokinase. I. Mechanism.

1986 • 206 citations

Congenital Deficiency of α2-Plasmin Inhibitor Associated with Severe Hemorrhagic Tendency *

1979 • 201 citations

Metalloproteinases in degenerative aortic disease

1991 • 196 citations

Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor.

1984 • 193 citations

Regulation of PAI-1 gene expression

1991 • 184 citations

Influence of the angiotensin system on endothelial and smooth muscle cell migration.

1990 • 184 citations

Urokinase‐type plasminogen activator mediates basic fibroblast growth factor‐induced bovine endothelial cell migration independent of its proteolytic activity

1992 • 183 citations

Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase.

1984 • 178 citations

Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma

1988 • 178 citations

Injury‐induced release of basic fibroblast growth factor from bovine aortic endothelium

1989 • 177 citations

The Receptor-Binding Sequence of Urokinase

1987 • 167 citations

Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells.

1989 • 163 citations

Human endothelial cells contain one type of plasminogen activator

1984 • 156 citations

Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase.

1992 • 153 citations

Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activator and urokinase.

1990 • 150 citations

Age dependence of ischaemic heart syndromes and the contribution of haemostatic deviations

1992 • 146 citations

Activation of plasminogen by single-chain urokinase or by two-chain urokinase--a demonstration that single-chain urokinase has a low catalytic activity (pro-urokinase)

1987 • 143 citations

Fibrinolytic System of Vascular Endothelial Cells

1988 • 138 citations

Proteolytic cleavage of single-chain pro-urokinase induces conformational change which follows activation of the zymogen and reduction of its high affinity for fibrin.

1985 • 138 citations

Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.

1987 • 129 citations

Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Implications

1989 • 124 citations

Protein Structure and Membrane Anchorage of the Cellular Receptor for Urokinase-Type Plasminogen Activator

1991 • 117 citations

Plasminogen activator inhibitor‐1 is induced in migrating endothelial cells

1992 • 115 citations

Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.

1990 • 109 citations

Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human cultured endothelial and glial cells

1977 • 108 citations

Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases, and tissue inhibitor of metalloproteinases by endothelial cells.

1990 • 107 citations

Primary structure of single-chain pro-urokinase.

1985 • 98 citations

The fibrinolytic system in man

1986 • 98 citations

Regulation of the Synthesis and Secretion of Plasminogen Activators by Endothelial Cells

1988 • 96 citations

Fibrinogen lysine residue A alpha 157 plays a crucial role in the fibrin-induced acceleration of plasminogen activation, catalyzed by tissue-type plasminogen activator.

1987 • 93 citations

Differential redistribution of platelet glycoproteins Ib and IIb-IIIa after plasmin stimulation [published erratum appears in Blood 1991 Jul 15;78(2):545]

1991 • 89 citations

Hemostasis in Patients Undergoing Extracorporeal Circulation: The Effect of Aprotinin (Trasylol)

1991 • 80 citations

Complexes between tissue-type plasminogen activator and proteinase inhibitors in human plasma, identified with an immunoradiometric assay.

1983 • 80 citations

A role of fibrinolytic activity in angiogenesis. Quantitative assay using in vitro method.

1989 • 78 citations

Congenital and acquired deficiencies of components of the fibrinolytic system and their relation to bleeding or thrombosis

1989 • 78 citations

Isolation and characterization of a urokinase-type plasminogen activator (Mr = 54,000) from cultured human endothelial cells indistinguishable from urinary urokinase.

1984 • 77 citations

The urokinase receptor and regulation of cell surface plasminogen activation

1990 • 75 citations

Localization in the fibrinogen γ-chain of a new site that is involved in the acceleration of the tissue-type plasminogen activator-catalysed activation of plasminogen

1992 • 63 citations

Tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon

1992 • 62 citations

Plasminogen Activator Inhibitor Type 1: Biochemistry and Evidence for Modulation of Fibrinolysis In Vivo

1992 • 61 citations

Release of vascular plasminogen activator (v‐PA) after venous stasis: electrophoretic—zymographic analysis of free and complexed v‐PA

1985 • 56 citations

Tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon

1992 • 46 citations

Urokinase-type plasminogen activator in endothelial cells during acute inflammation of the appendix.

1989 • 40 citations

Secretion of Plasminogen Activators by Cultured Bovine Endothelial Cells: Partial Purification, Characterization and Evidence for Multiple Forms

1981 • 37 citations

Elastase-like activity in cultured aortic endothelial cells

1989 • 14 citations

Interaction of platelets with endothelial cells: Activation of a novel neutral protease

1989 • 11 citations

Proteinase induction by endothelial cells during wound repair.

1988 • 10 citations

Modulation of Endothelial Cells Fibrinolytic Activity by Platelets

1991 • 9 citations

Regulation of Tissue Plasminogen Activator Secretion from Human Endothelial Cells

1990 • 2 citations

Deleted Work

1955 • 0 citations