Congenital and acquired deficiencies of components of the fibrinolytic system and their relation to bleeding or thrombosis

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

1987 • 1,516 citations

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

1982 • 1,300 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

The Peptide Chains of Human Plasmin

1967 • 478 citations

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

1985 • 405 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Deficient t-PA Release and Elevated PA Inhibitor Levels in Patients with Spontaneous or Recurrent Deep Venous Thrombosis

1987 • 373 citations

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets.

1984 • 365 citations

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

1986 • 343 citations

Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

1985 • 341 citations

On the Kinetics of the Reaction between Human Antiplasmin and Plasmin

1978 • 340 citations

Binding and activation of plasminogen on the platelet surface.

1985 • 312 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

Plasminogen activator inhibitor in the blood of patients with coronary artery disease.

1985 • 311 citations

Measurement of the binding of antifibrinolytic amino acids to various plasminogens

1972 • 308 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. Role in the regulation of fibrinolysis and identification as histidine-rich glycoprotein.

1980 • 289 citations

The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution

1974 • 279 citations

The primary inhibitor of plasmin in human plasma

1976 • 274 citations

On the specific interaction between the lysine-binding sites in plasmin and complementary sites in α2-antiplasmin and in fibrinogen

1979 • 269 citations

Abnormal Plasminogen

1978 • 259 citations

Plasma tissue plasminogen activator inhibitor levels in coronary artery disease: Correlation with age and serum triglyceride concentrations

1987 • 245 citations

Plasma levels of a specific inhibitor of tissue-type plasminogen activator (and urokinase) in normal and pathological conditions

1984 • 240 citations

The human tissue plasminogen activator gene.

1986 • 230 citations

Molecular cloning and characterization of a full‐length cDNA clone for human plasminogen

1987 • 229 citations

Purification and Characterization of Human Antiplasmin, the Fast-Acting Plasmin Inhibitor in Plasma

1977 • 228 citations

Assay of Human Tissue-Type Plasminogen Activator (t-PA) with an Enzyme-Linked Immunosorbent Assay (ELISA) Based on Three Murine Monoclonal Antibodies to t-PA

1985 • 213 citations

Preoperative prediction of postoperative deep vein thrombosis.

1976 • 210 citations

Determination of a new rapid plasmin inhibitor in human blood by means of a plasmin specific tripeptide substrate

1977 • 206 citations

Defective fibrinolysis in blood and vein walls in recurrent "idiopathic" venous thrombosis.

1972 • 206 citations

Congenital Deficiency of α2-Plasmin Inhibitor Associated with Severe Hemorrhagic Tendency *

1979 • 201 citations

Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor.

1984 • 193 citations

The specific interaction between plasminogen and fibrin. A physiological role of the lysine binding site in plasminogen

1977 • 193 citations

Haemostatic function in myocardial infarction.

1986 • 189 citations

Binding of plasminogen to extracellular matrix.

1986 • 175 citations

Characterization of human plasminogen. I. On the relationship between different molecular forms of plasminogen demonstrated in plasma and found in purified preparations.

1970 • 170 citations

Plasminogen Activator Inhibitor 1 and Plasminogen Activator Inhibitor 2 in Various Disease States

1988 • 165 citations

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator.

1984 • 164 citations

Determination of a new rapid plasmin inhibitor in human blood by means of a plasmin specific tripeptide substrate

1977 • 160 citations

Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin).

1987 • 160 citations

Analysis of coagulation and fibrinolysis during intravenous infusion of recombinant human tissue-type plasminogen activator in patients with acute myocardial infarction.

1986 • 154 citations

Measurement of human tissue-type plasminogen activator by a two-site immunoradiometric assay.

1983 • 142 citations

Postoperative Changes in the Plasmatic Levels of Tissue-Type Plasminogen Activator and Its Fast-Acting Inhibitor - Relationship to Deep Vein Thrombosis and Influence of Prophylaxis

1985 • 141 citations

The cell-binding domains of plasminogen and their function in plasma.

1988 • 134 citations

On the Kinetics of the Reaction between Human Antiplasmin and a Low-Molecular-Weight Form of Plasmin

1978 • 133 citations

Plasminogen interacts with human platelets through two distinct mechanisms.

1986 • 129 citations

Elevated levels of the rapid inhibitor of plasminogen activator (t-PAI) in acute myocardial infarction

1987 • 115 citations

Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns

1987 • 109 citations

Turnover of antiplasmin, the fast-acting plasmin inhibitor of plasma

1979 • 109 citations

The α2-plasmin inhibitor levels in liver diseases

1978 • 102 citations

The fibrinolytic system in man

1986 • 98 citations

Studies on the Isolation of the Multiple Molecular Forms of Human Plasminogen and Plasmin by Isoelectric Focusing Methods

1972 • 95 citations

Impaired Fibrinolytic Capacity Predisposes for Recurrence of Venous Thrombosis

1984 • 95 citations

Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen

1984 • 94 citations

Plasminogen activator in normal subjects after exercise and venous occlusion: t-PA circulates as complexes with C1-inhibitor and PAI-1

1987 • 94 citations

Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

1982 • 94 citations

Intravascular Coagulation in Liver Disease

1974 • 93 citations

Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

1987 • 92 citations

A monoclonal antibody specific for Lys-plasminogen. Application to the study of the activation pathways of plasminogen in vivo.

1985 • 90 citations

α2-PLASMIN-INHIBITOR DEFICIENCY (MIYASATO DISEASE)

1978 • 88 citations

Tissue plasminogen activator activity and inhibition in acute myocardial infarction and angiographically normal coronary arteries

1987 • 85 citations

α ₂ -Antiplasmin Enschede: Alanine Insertion and Abolition of Plasmin Inhibitory Activity

1987 • 82 citations

Complexes between tissue-type plasminogen activator and proteinase inhibitors in human plasma, identified with an immunoradiometric assay.

1983 • 80 citations

A familial hemorrhagic diathesis in a Dutch family: an inherited deficiency of alpha 2-antiplasmin

1982 • 78 citations

A bleeding disorder due to deficiency of alpha 2-antiplasmin

1982 • 76 citations

Genetic polymorphism of human plasminogen

1979 • 72 citations

Chromosomal Locations of Human Tissue Plasminogen Activator and Urokinase Genes

1985 • 72 citations

Physiological activation of the human fibrinolytic system. Isolation and characterization of human plasminogen variants, Chicago I and Chicago II.

1979 • 70 citations

A familial hemorrhagic diathesis in a Dutch family: an inherited deficiency of alpha 2-antiplasmin

1982 • 69 citations

Purification and reaction mechanism of the primary inhibitor of plasmin from human plasma

1978 • 68 citations

Increased concentration of the fast‐acting plasminogen activator inhibitor in plasma associated with familial venous thrombosis

1987 • 67 citations

A new life-long hemorrhagic disorder due to excess plasminogen activator

1983 • 62 citations

A bleeding disorder due to deficiency of alpha 2-antiplasmin

1982 • 62 citations

Molecular Biology of Human Plasminogen

1975 • 59 citations

Plasma fibrinolytic activity in patients undergoing major abdominal surgery.

1985 • 58 citations

Binding site of α2-plasmin inhibitor to plasminogen

1988 • 58 citations

Molecular biology of human plasminogen. I. Physiochemical properties and microheterogeneity.

1975 • 57 citations

Release of vascular plasminogen activator (v‐PA) after venous stasis: electrophoretic—zymographic analysis of free and complexed v‐PA

1985 • 56 citations

Abnormal plasminogen, a case of recurrent thrombosis

1981 • 54 citations

Homozygous protein C deficiency combined with heterozygous dysplasminogenemia found in a 21-year-old thrombophilic male

1985 • 50 citations

Genetic polymorphism of human plasminogen.

1980 • 49 citations

Amino‐acid sequence of human α₂‐antiplasmin

1987 • 49 citations

Recurring thromboembolic disease and pulmonary hypertension associated with severe hypoplasminogenemia

1985 • 47 citations

Human tissue-type plasminogen activator gene located near chromosomal breakpoint in myeloproliferative disorder.

1986 • 47 citations

Congenital Deficiency of α<sub>2</sub>-Plasmin Inhibitor in Three Sisters

1982 • 46 citations

Phenformin and Ethyloestrenol in Recurrent Venous Thrombosis

1975 • 45 citations

Differential proteolysis and evidence for a residue exchange in tissue plasminogen activator suggest possible association between two types of protein microheterogeneity

1983 • 45 citations

Molecular abnormality of plasminogen.

1980 • 43 citations

Fibrinolytic activity in plasma and deep vein thrombosis after major abdominal surgery

1983 • 42 citations

Plasminogen Paris I: Congenital abnormal plasminogen and its incidence in thrombosis

1983 • 41 citations

Differences of frequency distributions of plasminogen phenotypes between Japanese and American populations: New methods for the detection of plasminogen variants

1984 • 41 citations

Studies on a form of α2-antiplasmin in plasma which does not interact with the lysine-binding sites in plasminogen

1982 • 39 citations

Congenital plasminogen deficiency associated with venous thromboembolism: therapeutic trial with stanozolol

1986 • 39 citations

Inherited Fibrinolytic Disorder Due to an Enhanced Plasminogen Activator Level

1984 • 38 citations

Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency

1985 • 33 citations

Human Plasminogen Variant Chicago III

1982 • 32 citations

Measurement of free, one-chain tissue-type plasminogen activator in human plasma with an enzyme-linked immunosorbent assay based on an active site-specific murine monoclonal antibody

1987 • 32 citations

Relationship between preoperative status of the fibrinolytic system and occurrence of deep vein thrombosis after major abdominal surgery

1985 • 31 citations

Isolation of a human tissue-type plasminogen-activator genomic DNA clone and its expression in mouse L cells

1985 • 31 citations

A novel fast inhibitor to tissue plasminogen activator in plasma, which may be of great pathophysiological significance.

1985 • 30 citations

Genetic Polymorphism of Plasminogen: A New Basic Variant (PLG B) and Population Study in Japanese

1981 • 29 citations

Congenital Heterozygous Plasminogen Deficiency Associated with a Severe Thrombotic Tendency

1986 • 29 citations

Hereditary α2-antiplasmin deficiency

1983 • 27 citations

Proposal for the Nomenclature of Human Plasminogen (PLG) Polymorphism

1986 • 27 citations

Plasminogens Tochigi II and Nagoya: Two Additional Molecular Defects with Ala-600 → Thr Replacement Found in Plasmin Light Chain Variants123

1984 • 26 citations

Assignment of the human tissue-type plasminogen activator gene (PLAT) to chromosome 8

1986 • 25 citations

Investigation of a Congenital Abnormal Plasminogen, Frankfurt I, and Its Relationship to Thrombosis

1986 • 24 citations

Dysfunctional Plasminogen in Full Term Newborn - Study of Active Site of Plasmin

1984 • 23 citations

Genetic polymorphism of human plasminogen in the Japanese population: New plasminogen variants and relationship between plasminogen phenotypes and their biological activities

1982 • 21 citations

Synthetic Substrates in Clinical Blood Coagulation Assays

1980 • 21 citations

Polymorphism of Plasminogen in Healthy Individuals and Patients with Cerebral Infarction

1986 • 20 citations

Determination of Fast-Acting Plasmin Inhibitor (α<sub>2</sub>-Antiplasmin) in Plasma from Patients with Tendency to Thrombosis and Increased Fibrinolysis

1978 • 19 citations

α2-Antiplasmin: Functional Characterization and Metabolism in a Heterozygote Deficient Patient

1986 • 17 citations

Effect of hepatectomy on the posttraumatic fibrinolysis inhibition and the primary fibrinolysis inhibitor in the rat

1980 • 15 citations

A Sequential Study of Plasma Histidine-Rich Glycoprotein and Plasminogen in Patients with Acute Myocardial Infarction and Deep Vein Thrombosis

1984 • 15 citations

Plasma levels of selected haemostatic factors in newborn babies

1981 • 13 citations

Mini-plasminogen like molecule in septic patients

1987 • 13 citations

THE MUTUAL RELATION BETWEEN THE 2 MOLECULAR-FORMS OF ALPHA-2-ANTIPLASMIN IN BLOOD

1983 • 12 citations

Plasminogen abnormalities in patients with argentine hemorrhagic fever

1987 • 12 citations

Gene Frequencies of Plasminogen in Switzerland

1985 • 11 citations

Low Plasminogen Levels and Liver Disease

1969 • 10 citations

Three New Variants in the Plasminogen System

1982 • 8 citations

The plasminogen polymorphism in South African Negro populations: genetics and anthropogenetics

1986 • 8 citations

A Plasminogen Silent Allele Detected in a Swiss Family

1987 • 5 citations

Comparative Study of Phenotypes on Activity and Plasma Concentration in the Genetic System of Plasminogen

1983 • 4 citations

The Practice of Massage: Its Physiological Effects and Therapeutic Uses

1895 • 2 citations

Deleted Work

1955 • 0 citations