The pharmacogenetics of analgesia

Incidence of Adverse Drug Reactions in Hospitalized Patients

1998 • 4,749 citations

COMT val ¹⁵⁸ met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor

2003 • 1,103 citations

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

1997 • 995 citations

Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

2004 • 708 citations

Potential Role of Pharmacogenomics in Reducing Adverse Drug Reactions

2001 • 689 citations

Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism

2004 • 684 citations

Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

1999 • 648 citations

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

1999 • 543 citations

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

2003 • 509 citations

Kappa–opioids produce significantly greater analgesia in women than in men

1996 • 461 citations

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.

1993 • 429 citations

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

2006 • 426 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

The hypoalgesic effect of tramadol in relation to CYP2D6*

1996 • 398 citations

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution

1997 • 378 citations

The 118 A > G polymorphism in the human µ‐opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

2004 • 370 citations

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

2005 • 342 citations

Impact of CYP2D6 genotype on postoperative tramadol analgesia

2003 • 330 citations

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

2006 • 304 citations

Human Opioid Receptor A118G Polymorphism Affects Intravenous Patient-controlled Analgesia Morphine Consumption after Total Abdominal Hysterectomy

2006 • 301 citations

Association of μ‐opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty

2006 • 286 citations

The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain

1999 • 270 citations

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

1998 • 260 citations

Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability

2002 • 246 citations

Concentrations of Tramadol and O-desmethyltramadol Enantiomers in Different CYP2D6 Genotypes

2007 • 243 citations

A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling

2001 • 243 citations

Melanocortin-1 receptor gene variants affect pain and -opioid analgesia in mice and humans

2005 • 242 citations

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1996 • 238 citations

Involvement of Cytochrome P450 3A4 Enzyme in the N-Demethylation of Methadone in Human Liver Microsomes

1996 • 225 citations

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

2002 • 208 citations

Anesthetic Requirement Is Increased in Redheads

2004 • 184 citations

Codeine phosphate in paediatric medicine

2001 • 165 citations

A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects*1

2004 • 163 citations

Increased Sensitivity to Thermal Pain and Reduced Subcutaneous Lidocaine Efficacy in Redheads

2005 • 161 citations

Does the A118G Polymorphism at the μ-opioid Receptor Gene Protect against Morphine-6-Glucuronide Toxicity?

2002 • 144 citations

Clinically Significant Drug Interactions with Antidepressants in the Elderly

2002 • 141 citations

Genetic Polymorphisms in Monoamine Neurotransmitter Systems Show Only Weak Association with Acute Post-Surgical Pain in Humans

2006 • 128 citations

In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics

2001 • 121 citations

Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2

2002 • 119 citations

Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites

2003 • 116 citations

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

2001 • 114 citations

Candidate Gene Studies of Human Pain Mechanisms

2004 • 105 citations

Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population

2006 • 89 citations

Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans

2003 • 87 citations

Genetic influences in opioid analgesic sensitivity in mice

1991 • 80 citations

Allelic Variation S268P of the Human μ-Opioid Receptor Affects Both Desensitization and G Protein Coupling

2000 • 73 citations

No pain relief from codeine...?. An introduction to pharmacogenomics

2001 • 59 citations

A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment

2003 • 46 citations

Effect of amiodarone on the plasma levels of metoprolol

2004 • 42 citations

Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity

2003 • 29 citations