A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

1997 • 995 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

Summary of information on human CYP enzymes: human P450 metabolism data

2002 • 805 citations

Geographical/Interracial Differences in Polymorphic Drug Oxidation

1995 • 431 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution

1997 • 378 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

1990 • 304 citations

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1998 • 281 citations

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

1990 • 263 citations

Pharmacogenetic Phenotyping and Genotyping

1994 • 189 citations

Methadone N‐demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

1999 • 180 citations

“It's the genes, stupid” Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

1995 • 162 citations

Sex‐related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P‐glycoprotein

2002 • 158 citations

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

1993 • 143 citations

Steady‐state pharmacokinetics of (R)‐ and (S)‐methadone in methadone maintenance patients

2000 • 128 citations

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

2001 • 114 citations

Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers

1986 • 113 citations

Simultaneous Determination of Dextromethorphan and Three Metabolites in Plasma and Urine Using High-Performance Liquid Chromatography with Application to Their Disposition in Man

1990 • 112 citations

Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method

1981 • 106 citations

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.

1993 • 102 citations

Population pharmacokinetics of methadone in opiate users: characterization of time‐dependent changes

1999 • 101 citations

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.

1994 • 101 citations

The roles of P‐glycoprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac

1999 • 100 citations

Extensive Metabolizers of Debrisoquine Become Poor Metabolizers during Quinidine Treatment

1987 • 92 citations

Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts

1995 • 92 citations

Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.

1986 • 67 citations

Inhibition of desipramine 2-hydroxylation by quinidine and quinine

1988 • 66 citations

Sparteine oxidation is practically abolished in quinidine‐treated patients.

1986 • 64 citations

Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

1989 • 63 citations

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

1998 • 53 citations

Novel single-point plasma or saliva dextromethorphan method for determining CYP2D6 activity.

1998 • 49 citations

Dextromethorphan: polymorphic serum pattern of the O‐demethylated and didemethylated metabolites in man.

1989 • 46 citations

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

2000 • 42 citations

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

1995 • 38 citations

In-vivo indices of CYP2D6 activity: comparison of dextromethorphan metabolic ratios in 4-h urine and 3-h plasma

2000 • 36 citations

Determinants of Interindividual Variability and Extent of CYP2D6 and CYP1A2 Inhibition by Paroxetine and Fluvoxamine In Vivo

1998 • 26 citations

Deleted Work

1955 • 0 citations