A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects*1

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

1997 • 995 citations

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

2004 • 792 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Pharmacogenetics and adverse drug reactions

2000 • 605 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution

1997 • 378 citations

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

1998 • 284 citations

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1998 • 281 citations

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6

2001 • 269 citations

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

1994 • 196 citations

Elucidation of the genetic basis of the common ‘intermediate metabolizer’ phenotype for drug oxidation by CYP2D6

2000 • 189 citations

Pharmacogenetics of the major polymorphic metabolizing enzymes

2003 • 188 citations

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-rime PCR

2003 • 154 citations

Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment

2002 • 139 citations

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6

1992 • 123 citations

Comparison of Two CYP2D6 Genotyping Methods and Assessment of Genotype-Phenotype Relationships

2003 • 120 citations

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

2001 • 100 citations

Expression, Purification, Biochemical Characterization, and Comparative Function of Human Cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 Allelic Isoforms

2002 • 98 citations

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of the human cytochrome P450 CYP2D6 gene

1995 • 73 citations

CYP2D6 Poor Metabolizer Status Can Be Ruled Out by a Single Genotyping Assay for the −1584G Promoter Polymorphism

2003 • 72 citations

DUPLICATION, MULTIDUPLICATION, AND AMPLIFICATION OF GENES ENCODING DRUG-METABOLIZING ENZYMES: EVOLUTIONARY, TOXICOLOGICAL, AND CLINICAL PHARMACOLOGICAL ASPECTS

1999 • 58 citations

Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status

2003 • 58 citations

A sensitive capillary GC assay for the determination of sparteine oxidation products in microsomal fractions of human liver

1986 • 21 citations

In-vitro analysis of the contribution of CYP2D6.35 to ultra-rapid metabolism

2001 • 17 citations