Association of μ‐opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

1998 • 1,055 citations

The 118 A > G polymorphism in the human µ‐opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

2004 • 370 citations

Effect of the A118G polymorphism on binding affinity, potency and agonist‐mediated endocytosis, desensitization, and resensitization of the human mu‐opioid receptor

2004 • 259 citations

Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers

2003 • 222 citations

Gender differences in drug effects: implications for anesthesiologists

2003 • 215 citations

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

2002 • 208 citations

Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations

2003 • 177 citations

Opioid receptor and peptide gene polymorphisms: potential implications for addictions

2000 • 153 citations

Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts

2001 • 149 citations

Does the A118G Polymorphism at the μ-opioid Receptor Gene Protect against Morphine-6-Glucuronide Toxicity?

2002 • 144 citations

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

2002 • 132 citations

Candidate Gene Studies of Human Pain Mechanisms

2004 • 105 citations

The Transfer Half-life of Morphine-6-glucuronide from Plasma to Effect Site Assessed by Pupil Size Measurement in Healthy Volunteers

2001 • 95 citations

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

2003 • 89 citations

Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine

2000 • 87 citations

Detection of single nucleotide polymorphisms of the human mu opioid receptor gene by hybridization or single nucleotide extension on custom oligonucleotide gelpad microchips: Potential in studies of addiction

2000 • 62 citations

Preemptive Intravenous Morphine-6-glucuronide Is Ineffective for Postoperative Pain Relief

2000 • 48 citations

Is total knee replacement more painful than total hip replacement?

2000 • 42 citations

No contribution of morphine-6-glucuronide to clinical morphine effects after short-term administration.

1998 • 21 citations

Bioinformatic analysis of the human μ opioid receptor (OPRM1) splice and polymorphic variants

2002 • 18 citations

[Patient-controlled intravenous versus epidural analgesia after major joint replacement].

1992 • 2 citations