Clonal diversity and T-cell receptor beta-chain variable gene expression in enlarged lymph nodes of MRL-lpr/lpr lupus mice.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

High-Efficiency Cloning of Full-Length cDNA

1982 • 1,309 citations

A reliable method for the recovery of DNA fragments from agarose and acrylamide gels

1981 • 916 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.

1985 • 466 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Murine T-cell receptor mutants with deletions of beta-chain variable region genes.

1986 • 304 citations

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.

1982 • 295 citations

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

1984 • 290 citations

The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

1985 • 283 citations

Ontogeny of the T-cell antigen receptor within the thymus

1985 • 250 citations

Structure, expression and divergence of T-cell receptor β-chain variable regions

1984 • 237 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Rearrangement of T-cell receptor beta-chain genes during T-cell development.

1985 • 200 citations

T-Cell Receptor β-Chain Expression: Dependence on Relatively Few Variable Region Genes

1985 • 197 citations

Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

1983 • 188 citations

Treatment of murine lupus with monoclonal anti-T cell antibody.

1985 • 186 citations

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

1985 • 172 citations

A subcloning strategy for DNA sequence analysis

1980 • 161 citations

Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements

1986 • 151 citations

Experimental Autoimmune Encephalomyelitis in Mice: Immunologic Response to Mouse Spinal Cord and Myelin Basic Proteins

1975 • 145 citations

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice.

1981 • 128 citations

The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens.

1984 • 128 citations

Rearranged β t cell receptor genes in a helper t cell clone specific for lysozyme: No correlation between Vβ and MHC restriction

1985 • 120 citations

Genetic Control of Antibody Variable Regions

1977 • 112 citations

B cell dependence on and response to accessory signals in murine lupus strains.

1983 • 108 citations

Lupus prone (SWR x NZB)F1 mice produce potentially nephritogenic autoantibodies inherited from the normal SWR parent.

1985 • 107 citations

A Large Deletion Within the T-Cell Receptor Beta-Chain Gene Complex in New Zealand White Mice

1985 • 105 citations

Autoimmunity and Increased c-mybTranscription

1984 • 89 citations

The influence of the lpr gene on B cell activation: Differential antibody expression in lpr congenic mouse strains

1984 • 81 citations

The lymphoproliferating cells of MRL‐lpr/lpr mice are a polyclonal population that bear the T lymphocyte receptor for antigen

1985 • 80 citations

Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells

1985 • 79 citations

Vβ gene polymorphism and a major polyclonal T cell receptor idiotype

1985 • 75 citations

Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity.

1986 • 68 citations

Cellular basis of in vitro anti-DNA antibody production: evidence for T cell dependence of IgG-class anti-DNA antibody synthesis in the (NZB X NZW)F1 hybrid.

1986 • 68 citations

Alternative splicing of murine T-cell receptor β-chain transcripts

1986 • 44 citations

Cellular aspects of tolerance

1974 • 30 citations

Hodgkin's disease. SJL/J murine lymphoma.

1983 • 16 citations