Endocytosis of Epidermal Growth Factor Receptor Regulated by Grb2-mediated Recruitment of the Rab5 GTPase-activating Protein RN-tre

Untangling the ErbB signalling network

2001 • 6,623 citations

The EGFR family and its ligands in human cancer

2001 • 1,554 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

The Rab5 effector EEA1 is a core component of endosome docking

1999 • 850 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

The Structural Era of Endocytosis

1999 • 560 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Rab5 regulates motility of early endosomes on microtubules

1999 • 504 citations

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1995 • 476 citations

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1998 • 395 citations

Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis and Intracellular Trafficking

2001 • 386 citations

The dynamin family of mechanoenzymes: pinching in new places

2000 • 345 citations

The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor

1999 • 308 citations

Ras-Activated Endocytosis Is Mediated by the Rab5 Guanine Nucleotide Exchange Activity of RIN1

2001 • 307 citations

Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

2000 • 301 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

2000 • 288 citations

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

2002 • 280 citations

Endocytosis of growth factor receptors

1993 • 277 citations

A novel role for Rab5–GDI in ligand sequestration into clathrin-coated pits

1998 • 273 citations

Epidermal Growth Factor and Membrane Trafficking

2000 • 233 citations

A novel peptide-SH3 interaction

1999 • 188 citations

Coordinated Traffic of Grb2 and Ras during Epidermal Growth Factor Receptor Endocytosis Visualized in Living Cells

2002 • 186 citations

Requirement for the Adapter Protein GRB2 in EGF Receptor Endocytosis

1996 • 178 citations

Involvement of She in Insulin- and Epidermal Growth Factor-Induced Activation of p21^ras

1994 • 174 citations

Dynamin

1998 • 172 citations

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.

1994 • 160 citations

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

2000 • 143 citations

Synaptojanin 2, a Novel Synaptojanin Isoform with a Distinct Targeting Domain and Expression Pattern

1997 • 101 citations

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

1995 • 68 citations

Structural insights into clathrin-mediated endocytosis

2000 • 56 citations

Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin 1 1Edited by A. R. Fersht

1999 • 51 citations

Differential Interactions of the Growth Factor Receptor-bound Protein 2 N-SH3 Domain with Son of Sevenless and Dynamin

1998 • 44 citations

Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus

1998 • 41 citations

RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation.

1996 • 41 citations

RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain.

1996 • 29 citations

The GDP/GTP Cycle of Rab5 in the Regulation of Endocytotic Membrane Traffic

1995 • 23 citations

Regulation of endocytosis by the small GTP-ase Rab5

1993 • 19 citations