Endocytosis of growth factor receptors

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis.

1982 • 399 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.

1984 • 357 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

1984 • 295 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.

1984 • 265 citations

Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor

1979 • 254 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

Interaction of platelet-derived growth factor with its fibroblast receptor. Demonstration of ligand degradation and receptor modulation.

1982 • 239 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

1986 • 217 citations

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

The interaction of 125I-colony-stimulating factor-1 with bone marrow-derived macrophages.

1986 • 205 citations

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts.

1982 • 171 citations

Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.

1991 • 166 citations

The mechanism of receptor‐mediated endocytosis

1991 • 164 citations

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors.

1992 • 150 citations

Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells.

1986 • 148 citations

Internalization of functional epidermal growth factor:receptor/kinase complexes in A-431 cells.

1985 • 128 citations

Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis

1991 • 114 citations

The Pathway of Endocytosis

1985 • 112 citations

The mechanism of receptor‐mediated endocytosis: More questions than answers

1992 • 103 citations

Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathways.

1991 • 102 citations

Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalization.

1989 • 101 citations

Receptor-mediated endocytosis of transferrin and epidermal growth factor receptors: a comparison of constitutive and ligand-induced uptake

1985 • 101 citations

Kinetics of binding, endocytosis, and recycling of EGF receptor mutants

1992 • 100 citations

Characterization of the metabolic turnover of epidermal growth factor receptor protein in A‐431 cells

1984 • 94 citations

Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration

1990 • 91 citations

Cellular trafficking and processing of the insulin receptor ¹

1991 • 89 citations

Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines

1991 • 88 citations

The endocytosis of epidermal growth factor in A431 cells: A pH of microenvironment and the dynamics of receptor complex dissociation

1988 • 88 citations

Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo.

1989 • 88 citations

Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells.

1987 • 85 citations

Epidermal growth factor receptor kinase translocation and activation in vivo.

1986 • 81 citations

Perinuclear location and recycling of epidermal growth factor receptor kinase: immunofluorescent visualization using antibodies directed to kinase and extracellular domains.

1986 • 78 citations

Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes. Monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factor.

1988 • 78 citations

Dimerization of internalized epidermal growth factor receptors.

1991 • 75 citations

The role of kinase activity and the kinase insert region in ligand-induced internalization and degradation of the c-fms protein.

1991 • 75 citations

Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.

1991 • 63 citations

Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry.

1985 • 57 citations

Association of the tyrosine phosphorylated epidermal growth factor receptor with a 55-kD tyrosine phosphorylated protein at the cell surface and in endosomes.

1992 • 54 citations

Recycling of epidermal growth factor-receptor complexes in A431 cells

1989 • 48 citations

Visualization of epidermal growth factor receptor in cryosections of cultured A431 cells by immuno-gold labeling.

1985 • 48 citations

Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis.

1991 • 46 citations

Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism

1992 • 21 citations

The Compartments of the Endocytic Pathway

1992 • 7 citations