Sp3 Represses Gene Expression via the Titration of Promoter-specific Transcription Factors

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

1999 • 607 citations

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

1992 • 533 citations

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.

1994 • 531 citations

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

1988 • 485 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β

2000 • 392 citations

Cloning of an Intrinsic Human TFIID Subunit That Interacts with Multiple Transcriptional Activators

1995 • 385 citations

The von Hippel-Lindau Tumor Suppressor Gene Product Interacts with Sp1 To Repress Vascular Endothelial Growth Factor Promoter Activity

1997 • 345 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

An Approach to Random Mutagenesis of DNA Using Mixtures of Triphosphate Derivatives of Nucleoside Analogues

1996 • 312 citations

Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1.

1993 • 310 citations

Interaction between transcription factors Spl and YY1

1993 • 282 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription

1997 • 248 citations

Shear stress induction of the tissue factor gene.

1997 • 238 citations

The Role of the Transcription Factor Sp1 in Regulating the Expression of the WAF1/CIP1 Gene in U937 Leukemic Cells

1996 • 215 citations

Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression.

1995 • 212 citations

Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.

1993 • 203 citations

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

1997 • 202 citations

Negative Regulation of DNA Replication by the Retinoblastoma Protein Is Mediated by Its Association with MCM7

1998 • 186 citations

Sp1 Is Required for the Early Response of α2(I) Collagen to Transforming Growth Factor-β1

1997 • 175 citations

Hypoxia Regulates β-Enolase and Pyruvate Kinase-M Promoters by Modulating Sp1/Sp3 Binding to a Conserved GC Element

1998 • 167 citations

Nerve Growth Factor Induces Transcription of the p21 WAF1/CIP1 and Cyclin D1 Genes in PC12 Cells by Activating the Sp1 Transcription Factor

1997 • 156 citations

A Conserved Downstream Element Defines a New Class of RNA Polymerase II Promoters

1995 • 155 citations

Involvement of the Sp3 Transcription Factor in Induction of p21 in Keratinocyte Differentiation

1997 • 134 citations

Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain.

1994 • 128 citations

The corepressor N-CoR and its variants RIP13a and RIP13 1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70

1998 • 128 citations

Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter

1989 • 123 citations

Sp1 Mediates Glucose Activation of the Acetyl-CoA Carboxylase Promoter

1996 • 115 citations

A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

1993 • 107 citations

Association of p107 with Sp1: Genetically Separable Regions of p107 Are Involved in Regulation of E2F- and Sp1-Dependent Transcription

1995 • 98 citations

p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat

1995 • 97 citations

Two Sp1-binding Sites Mediate cAMP-induced Transcription of the Bovine CYP11A Gene through the Protein Kinase A Signaling Pathway

1995 • 96 citations

Cooperation of E2F-p130 and Sp1-pRb Complexes in Repression of the Chinese Hamster dhfr Gene

2001 • 64 citations

Epidermal Growth Factor and Okadaic Acid Stimulate Sp1 Proteolysis

1997 • 56 citations

Activator Protein-2 Mediates Transcriptional Activation of the CYP11A1 Gene by Interaction with Sp1 Rather than Binding to DNA

1999 • 56 citations

Genetic Dissection of hTAFII130 Defines a Hydrophobic Surface Required for Interaction with Glutamine-rich Activators

1999 • 39 citations

An alternatively spliced form of the transcription factor Sp1 containing only a single glutamine-rich transactivation domain.

1995 • 36 citations

An inhibitory Raf-1 mutant suppresses expression of a subset of v-raf-activated genes

1993 • 35 citations

A common set of nuclear factors bind to promoter elements regulated by the retinoblastoma protein.

1992 • 30 citations

The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity

1999 • 28 citations