Epidermal Growth Factor and Okadaic Acid Stimulate Sp1 Proteolysis

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Transcriptional regulation

1991 • 893 citations

O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation

1988 • 884 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

1990 • 586 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.

1993 • 480 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators

1994 • 374 citations

[46] Clonal strains of hormone-producing pituitary cells

1979 • 296 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Regulated degradation of the transcription factor Gcn4.

1994 • 271 citations

The retinoblastoma gene product regulates Sp1-mediated transcription.

1992 • 253 citations

Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene

1991 • 227 citations

Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the Liver

1995 • 210 citations

Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.

1993 • 203 citations

Epidermal growth factor and expression of specific genes: effects on cultured rat pituitary cells are dissociable from the mitogenic response.

1980 • 191 citations

The Retinoblastoma Gene Product RB Stimulates Spl-Mediated Transcription by Liberating Spl from a Negative Regulator

1994 • 189 citations

An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate.

1989 • 127 citations

SV40 stimulates expression of the transacting factor Sp1 at the mRNA level.

1990 • 124 citations

Purification and Characterization of a Z-Leu-Leu-Leu-MCA Degrading Protease Expected to Regulate Neurite Formation: A Novel Catalytic Activity in Proteasome

1993 • 117 citations

Targeted Degradation of c-Fos, But Not v-Fos, by a Phosphorylation-Dependent Signal on c-Jun

1992 • 110 citations

Tumor-Promoting Phorbol Esters Affect Production of Prolactin and Growth Hormone by Rat Pituitary Cells*

1981 • 98 citations

Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells

1991 • 94 citations

A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter.

1991 • 85 citations

Epidermal Growth Factor Stimulation of the Human Gastrin Promoter Requires Sp1

1995 • 85 citations

NF-I/Sp1 Switch Elements Regulate Collagen α1(I) Gene Expression

1992 • 70 citations

The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomas

1992 • 64 citations

Okadaic acid inhibits a protein phosphatase activity involved in formation of the mitotic spindle of GH₄ rat pituitary cells

1992 • 39 citations

Inhibition of myogenesis by okadaic acid, an inhibitor of protein phosphatases, 1 and 2A, correlates with the induction of AP1.

1992 • 36 citations

Appearance of Nuclear Protease Activity after Embryonal Carcinoma Cells Undergo Differentiation

1996 • 35 citations