The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated

2004 • 1,253 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

Systemic effects of local radiotherapy

2009 • 906 citations

Regulatory T cells in tumor immunity

2010 • 902 citations

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

1985 • 721 citations

Molecular Mechanisms of Treg-Mediated T Cell Suppression

2012 • 657 citations

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

2008 • 650 citations

Primary Antitumor Immune Response Mediated by CD4+ T Cells

2005 • 444 citations

GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3 ⁺ regulatory T cells

2009 • 430 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

2007 • 333 citations

Regulatory T cells and cancer

2007 • 325 citations

Identification of Potential mRNA Biomarkers in Peripheral Blood Lymphocytes for Human Exposure to Ionizing Radiation

2000 • 290 citations

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

2009 • 246 citations

Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF

2009 • 241 citations

Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells

2011 • 231 citations

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

2009 • 217 citations

Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production

2011 • 201 citations

Mechanisms of T regulatory cell function

2008 • 176 citations

Cutting Edge: In Contrast to Effector T Cells, CD4+CD25+FoxP3+ Regulatory T Cells Are Highly Susceptible to CD95 Ligand- but Not to TCR-Mediated Cell Death

2005 • 171 citations

Emerging possibilities in the development and function of regulatory T cells

2006 • 161 citations

Human regulatory T cells and autoimmunity

2008 • 159 citations

Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration.

2003 • 158 citations

FOXP3 and survival in urinary bladder cancer

2011 • 158 citations

Effects of Low-Dose Radiation on the Immune System of Mice after Total-Body Irradiation

2010 • 140 citations

Dendritic Cells Support Homeostatic Expansion of Foxp3+ Regulatory T Cells in Foxp3.LuciDTR Mice

2010 • 129 citations

Suppressive properties of human CD4⁺CD25⁺ regulatory T cells are dependent on CTLA‐4 expression

2004 • 126 citations

Gamma-Ray Resistance of Regulatory CD4⁺CD25⁺Foxp3⁺T Cells in Mice

2009 • 119 citations

Sequential Immunotherapy by Vaccination With GM-CSF–expressing Glioma Cells and CTLA-4 Blockade Effectively Treats Established Murine Intracranial Tumors

2012 • 119 citations

Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells.

1986 • 102 citations

Full restoration of peripheral Foxp3 ⁺ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras

2007 • 96 citations

Human regulatory T cells in autoimmune diseases

2010 • 88 citations

FOXP3+ regulatory T cells: From suppression of rejection to induction of renal allograft tolerance

2011 • 77 citations

2-Gy whole-body irradiation significantly alters the balance of CD4+CD25−T effector cells and CD4+CD25+Foxp3+T regulatory cells in mice

2010 • 68 citations

TGF-β Induces Surface LAP Expression on Murine CD4 T Cells Independent of Foxp3 Induction

2010 • 67 citations

Human Regulatory T Cells Rapidly Suppress T Cell Receptor–Induced Ca ²⁺ , NF-κB, and NFAT Signaling in Conventional T Cells

2011 • 60 citations

Clinical Studies With Anti–CTLA-4 Antibodies in Non-melanoma Indications

2010 • 59 citations

Local tumor irradiation augments the antitumor effect of cytokine-producing autologous cancer cell vaccines in a murine glioma model

2002 • 57 citations

Gamma irradiation alters the phenotype and function of CD4⁺CD25⁺ regulatory T cells

2009 • 57 citations

Prognostic value of tumor-infiltrating Foxp3+ T-cell subpopulations in metastatic melanoma

2011 • 52 citations

Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT

2008 • 52 citations

Abdominal γ-Radiation Induces an Accumulation of Function-Impaired Regulatory T Cells in the Small Intestine

2011 • 51 citations

The impact of CD4+CD25+ T cells in the tumor microenvironment of hepatocellular carcinoma

2011 • 50 citations

Different radiosensitivity of CD4⁺CD25⁺regulatory T cells and effector T cells to low dose gamma irradiation in vitro

2010 • 49 citations

Importance of CD4+ Helper T-cells in Antitumor Immunity

2003 • 48 citations

Immunofluorescence-detected infiltration of CD4[+]FOXP3[+] regulatory T cells is relevant to the prognosis of patients with endometrial cancer

2012 • 45 citations

Acute Effects of Iron-Particle Radiation on Immunity. Part II: Leukocyte Activation, Cytokines and Adhesion

2006 • 39 citations

Selective Radiation Resistance of Immunologically Induced T Cells as the Basis for Irradiation-Induced T-Cell-Mediated Regression of Immunogenic Tumor

1991 • 38 citations

Gamma Irradiation-reduced IFN-γ Expression, STAT1 Signals, and Cell-mediated Immunity

2002 • 35 citations

Sublethal, whole-body ionizing irradiation can be tumor promotive or tumor destructive depending on the stage of development of underlying antitumor immunity

1988 • 34 citations

Complete elimination of established neuroblastoma by synergistic action of γ-irradiation and DCs treated with rSeV expressing interferon-β gene

2008 • 28 citations

Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells

2006 • 27 citations

Apoptosis of circulating lymphocytes induced by whole body gamma-irradiation and its mechanism.

1999 • 25 citations

Radiation-induced apoptosis in mouse lymphocytes is modified by a complex dietary supplement: the effect of genotype and gender

2008 • 23 citations

Low‐dose total body irradiation augments the therapeutic effect of interleukin‐2 in a mouse model for metastatic malignant melanoma

2003 • 22 citations

Low-dose Photon and Simulated Solar Particle Event Proton Effects on Foxp3⁺T Regulatory Cells and other Leukocytes

2010 • 22 citations

Synergistic anti-tumor effect of combination radio- and immunotherapy by electro-gene therapy plus intra-tumor injection of dendritic cells

2008 • 20 citations

Randomized controlled phase I/II study to investigate immune stimulatory effects by low dose radiotherapy in primarily operable pancreatic cancer

2011 • 19 citations

Novel Therapies in Melanoma

2011 • 18 citations

IN VIVO STUDIES OF THE MAINTENANCE OF PERIPHERAL TRANSPLANT TOLERANCE AFTER CYCLOSPORINE

1995 • 16 citations

Monotherapeutically Nonactive CTLA-4 Blockade Results in Greatly Enhanced Antitumor Effects When Combined With Tumor-targeted Superantigens in a B16 Melanoma Model

2012 • 14 citations

Increased Expression of Fas (APO-1, CD95) on CD4+ and CD8+ T Lymphocytes during Total Body Irradiation

2000 • 7 citations

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