Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

2010 • 1,711 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

2009 • 882 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

2006 • 677 citations

Reversal of the TCR Stop Signal by CTLA-4

2006 • 584 citations

High-Dose Granulocyte-Macrophage Colony-Stimulating Factor-Producing Vaccines Impair the Immune Response through the Recruitment of Myeloid Suppressor Cells

2004 • 520 citations

Immune regulation by 4‐1BB and 4‐1BBL: complexities and challenges

2009 • 281 citations

The Mechanism of Anti-CTLA-4 Activity and the Negative Regulation of T-Cell Activation

2008 • 230 citations

4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells

2003 • 172 citations

Combination Therapy with Anti–CTL Antigen-4 and Anti-4-1BB Antibodies Enhances Cancer Immunity and Reduces Autoimmunity

2006 • 168 citations

The 4-1BB Costimulation Augments the Proliferation of CD4+CD25+ Regulatory T Cells

2004 • 157 citations

IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response

2008 • 154 citations

Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses

2002 • 145 citations

Ex Vivo Expansion of CD4+CD25+FoxP3+ T Regulatory Cells Based on Synergy between IL-2 and 4-1BB Signaling

2007 • 139 citations

Tumor Vaccines Expressing Flt3 Ligand Synergize with CTLA-4 Blockade to Reject Preimplanted Tumors

2009 • 131 citations

Characterization of mouse CD4 T cell subsets defined by expression of KLRG1

2007 • 79 citations

Stimulation with 4-1BB (CD137) inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells

2004 • 71 citations

Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb

2007 • 59 citations

Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent

2007 • 58 citations

Optimising anti‐tumour CD8 T‐cell responses using combinations of immunomodulatory antibodies

2008 • 54 citations