Double-negative thymocyte subsets in CD3′ chain-deficient mice: Absence of HSA+CD44−CD25− cells

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Control points in early T-cell development

1993 • 429 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Differentiation potential of subsets of CD4−8− thymocytes

1987 • 169 citations

Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development.

1986 • 167 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

1989 • 128 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

A role for a pre-T-cell receptor in T-cell development

1993 • 114 citations

Cell proliferation and differentiation in the fetal and early postnatal mouse thymus.

1989 • 104 citations

Cellular aspects of early T-cell development

1992 • 91 citations

Phenotypic changes accompanying positive selection of CD4⁺CD8⁺ thymocytes

1992 • 64 citations

Heterogeneity of immature (Lyt-2-/L3T4-) thymocytes. Identification of four major phenotypically distinct subsets differing in cell cycle status and in vitro activation requirements.

1988 • 57 citations

T cell receptor β chain dimers on immature thymocytes from normal mice

1993 • 57 citations

Characterization of the subset of immature thymocytes which can undergo rapid in vitro differentiation

1989 • 54 citations

Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells.

1993 • 50 citations

T cell receptor expression on immature thymocytes with in vivo and in vitro precursor potential

1989 • 39 citations

Subpopulations of CD4-CD8-murine thymocytes: differences in proliferation rate in vivo and proliferative responses in vitro

1988 • 32 citations

Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages.

1993 • 22 citations

Ontogeny of fetal CD8^lo4^lo thymocytes: Expression of CD44, CD25 and early expression of TcR α mRNA

1993 • 19 citations