Down's Syndrome and Aging: Is Senile Dementia Inevitable?

Journal of Mental Deficiency Research

1957 • 1,185 citations

A general model for the study of developmental problems.

1965 • 1,048 citations

The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

1973 • 340 citations

PRESENILE DEMENTIA AND ALZHEIMER'S DISEASE IN MONGOLISM

1969 • 292 citations

ADVANCES IN BEHAVIORAL BIOLOGY

1972 • 271 citations

EARLY SENILE DEMENTIA IN MONGOLOID IDIOCY

1948 • 221 citations

Presenile dementia in Down's syndrome

1974 • 219 citations

Relationship between plaques, tangles, and dementia in Down syndrome

1980 • 189 citations

Neuropathology of Organic Brain Syndromes Associated with Aging

1972 • 182 citations

Precocious aging and dementia in patients with Down's syndrome.

1978 • 154 citations

Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in down syndrome: Quantitative comparison with alzheimer dementia

1980 • 143 citations

Biological psychiatry

1996 • 123 citations

Alzheimer's Disease, Trisomy 21, and Myeloproliferative Disorders: Associations Suggesting a Genetic Diathesis

1977 • 110 citations

Alzheimer's disease in Down's syndrome.

1971 • 101 citations

Alzheimer Degeneration in Down Syndrome

1975 • 93 citations

Alzheimer's Disease in Down's Syndrome: Visual Retention Deficits

1974 • 79 citations

Histopathologische Untersuchungen über Entstehung und Wesen der senilen Plaques

1929 • 77 citations

Alzheimer's disease and senile dementia as seen in mongoloids: neuropathological observations.

1966 • 72 citations

Neurofibrillary tangles in patients with Down's syndrome: A light and electron microscopic study

1973 • 64 citations

TOPOGRAPHY OF NEUROFIBRILLARY TANGLES AND GRANULOVACUOLES IN HIPPOCAMPI OF PATIENTS WITH DOWN'S SYNDROME: QUANTITATIVE COMPARISON WITH NORMAL AGEING AND ALZHEIMER'S DISEASE

1981 • 62 citations

DEMENTIA IN AGEING MENTAL DEFECTIVES: A CLINICAL PSYCHIATRIC STUDY

1974 • 56 citations

ELECTRON MICROSCOPICAL STUDY OF THE BRAIN IN DOWN'S SYNDROME

1972 • 48 citations

Life span changes in the averaged evoked responses of Down's syndrome and nonretarded persons.

1978 • 35 citations

The Effect of Age on the Intellectual Performance of Mental Defectives

1960 • 24 citations

Alzheimer's disease in Down syndrome: clinical-neuropathological observations.

1969 • 23 citations

PREMATURE SENILITY IN DOWN'S SYNDROME

1970 • 21 citations

Behavior of low-grade institutionalized mongoloids: changes with age.

1970 • 20 citations

Nature of institutionalized adult mongoloid intelligence.

1961 • 9 citations

MA changes in institutionalized Down's syndrome persons: a semi-longitudinal approach.

1978 • 6 citations