Relative Effects of α- and γ-Tocopherol on Low-Density Lipoprotein Oxidation and Superoxide Dismutase and Nitric Oxide Synthase Activity and Protein Expression in Rats

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Antioxidants and Atherosclerotic Heart Disease

1997 • 1,390 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Dietary Antioxidant Vitamins and Death from Coronary Heart Disease in Postmenopausal Women

1996 • 976 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

γ-Tocopherol traps mutagenic electrophiles such as NO _x and complements α-tocopherol: Physiological implications

1997 • 533 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant

1992 • 513 citations

Inactivation of endothelial derived relaxing factor by oxidized lipoproteins.

1992 • 452 citations

Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine

1998 • 444 citations

Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.

1993 • 337 citations

α-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C–Dependent Mechanism

1996 • 309 citations

Oral α-Tocopherol Supplements Decrease Plasma γ-Tocopherol Levels in Humans

1985 • 267 citations

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.

1994 • 228 citations

Preservation of Endogenous Antioxidant Activity and Inhibition of Lipid Peroxidation as Common Mechanisms of Antiatherosclerotic Effects of Vitamin E, Lovastatin and Amlodipine

1997 • 208 citations

Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation.

1996 • 203 citations

Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.

1995 • 202 citations

Vitamin E Improves the Free Radical Defense System Potential and Insulin Sensitivity of Rats Fed High Fructose Diets

1997 • 181 citations

Oxidized LDL Decreases <scp>l</scp> -Arginine Uptake and Nitric Oxide Synthase Protein Expression in Human Platelets

1996 • 178 citations

Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients

1996 • 176 citations

Oxysterols Induced Apoptosis in Cultured Smooth Muscle Cells through CPP32 Protease Activation and bcl-2 Protein Downregulation

1996 • 145 citations

The Role of Oxidized Low Density Lipoprotein in Atherogenesis

1996 • 138 citations

Thiol modulation of TNF? and IL-1 induced MnSOD gene expression and activation of NF-?B

1995 • 128 citations

α-Tocopherol Enrichment of Monocytes Decreases Agonist-Induced Adhesion to Human Endothelial Cells

1998 • 127 citations

Role of reactive oxygen species in the signalling cascade of cyclosporine A‐mediated up‐regulation of eNOS in vascular endothelial cells

1998 • 126 citations

σ-Tocopherol: An Efficient Protector of Lipids Against Nitric Oxide-initiated Peroxidative Damage

2009 • 91 citations

NFκB-Independent Transcriptional Induction of the Human Manganous Superoxide Dismutase Gene

1997 • 64 citations

Free oxygen radicals contribute to platelet aggregation and cyclic flow variations in stenosed and endothelium-injured canine coronary arteries

1994 • 63 citations

Experimental thrombosis model induced by free radicals. Application to aspirin and other different substances

1995 • 44 citations

Oxidized Low Density Lipoproteins Alter Macrophage Lipid Uptake, Apoptosis, Viability and Nitric Oxide Synthesis

1996 • 40 citations

Vitamins C and E Prolong Time to Arterial Thrombosis in Rats

1999 • 38 citations

Superoxide Dismutase Decreases Reperfusion Arrhythmias and Preserves Myocardial Function During Thrombolysis with Tissue Plasminogen Activator

1990 • 37 citations