The Product of the cbl Oncogene Forms Stable Complexes In Vivo with Endogenous Crk in a Tyrosine Phosphorylation-Dependent Manner

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

1987 • 448 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

c-Abl kinase regulates the protein binding activity of c-Crk.

1994 • 362 citations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

1989 • 316 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

1995 • 288 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

1994 • 232 citations

Interactions of Cbl with Grb2 and Phosphatidylinositol 3′-Kinase in Activated Jurkat Cells

1995 • 217 citations

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1994 • 211 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

Isolation and chromosomal localization of CRKL, a human crk-like gene.

1993 • 203 citations

Tyrosine Phosphorylation of the c-cbl Proto-oncogene Protein Product and Association with Epidermal Growth Factor (EGF) Receptor upon EGF Stimulation

1995 • 202 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

GRB2 and Phospholipase C-7γ1 Associate with a 36- to 38-Kilodalton Phosphotyrosine Protein after T-Cell Receptor Stimulation

1994 • 181 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Tyrosine Phosphorylation and Translocation of the c-Cbl Protein after Activation of Tyrosine Kinase Signaling Pathways

1995 • 171 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene

1994 • 148 citations

The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

1992 • 147 citations

Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

1990 • 128 citations

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.

1991 • 127 citations

Cellular interactions of CRKL, and SH2-SH3 adaptor protein.

1994 • 116 citations

The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation.

1993 • 109 citations

Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.

1993 • 100 citations

Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways.

1995 • 100 citations

Binding of NCK to SOS and Activation of ras-Dependent Gene Expression

1995 • 94 citations

The SH3 Domain of Crk Binds Specifically to a Conserved Proline-rich Motif in Eps15 and Eps15R

1995 • 89 citations

The Human Leukemia Oncogene bcr-abl Abrogates the Anchorage Requirement but Not the Growth Factor Requirement for Proliferation

1995 • 87 citations

In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.

1994 • 75 citations

Crk Interacts with Tyrosine-phosphorylated p116 upon T Cell Activation

1995 • 72 citations

Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol.

1994 • 57 citations

Inhibition of binding of phospholipase Cγ1 SH2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides

2009 • 27 citations