Complement—immunoglobulin interactions

HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOOD

1981 • 1,659 citations

Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG

1985 • 1,136 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

The binding site for C1q on IgG

1988 • 556 citations

Quantitative Determination of Antibody in Idiopathic Thrombocytopenic Purpura

1975 • 453 citations

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

1978 • 415 citations

Complement Fixation on Cell Surfaces by 19 S and 7 S Antibodies

1965 • 336 citations

Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.

1988 • 269 citations

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation.

1993 • 241 citations

The reaction of monomeric and aggregated immunoglobulins with Cl

1971 • 225 citations

Effect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1.

1994 • 190 citations

Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes.

1994 • 184 citations

Mechanism of therapeutic effect of high-dose intravenous immunoglobulin. Attenuation of acute, complement-dependent immune damage in a guinea pig model.

1989 • 180 citations

Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling

1991 • 172 citations

The structure and function of immunoglobulin domains. IV. The distribution of some effector functions among the Cgamma2 and Cgamma3 homology regions of human immunoglobulin G1.

1976 • 165 citations

Effects of galactose depletion from oligosaccharide chains on immunological activities of human IgG.

1989 • 162 citations

The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain.

1991 • 128 citations

Antigen-bound C3b and C4b enhance antigen-presenting cell function in activation of human T-cell clones.

1988 • 121 citations

On the structure of polymeric IgM

1988 • 115 citations

The effects of intravenous immune globulin on complement-dependent immune damage of cells and tissues

1992 • 110 citations

High doses of intravenous Ig inhibit in vitro uptake of C4 fragments onto sensitized erythrocytes

1991 • 108 citations

The Structure and Function of Immunoglobulin Domains

1976 • 107 citations

Localization of sites through which C-reactive protein binds and activates complement to residues 14-26 and 76-92 of the human C1q A chain.

1992 • 106 citations

High-dose intravenous immunoglobulin modifies complement-mediated in vivo clearance

1989 • 106 citations

Intermolecular disulfide bonding in IgM: effects of replacing cysteine residues in the mu heavy chain.

1989 • 104 citations

The role of antibody in the activation of the alternative complement pathway

1983 • 95 citations

IgM - molecular requirements for its assembly and function

1989 • 92 citations

C1: molecular interactions with activating systems

1991 • 90 citations

Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells.

1993 • 67 citations

The Relationship Between Antibody Affinity and the Efficiency of Complement Fixation

1970 • 67 citations

Residue at position 331 in the IgG1 and IgG4 CH2 domains contributes to their differential ability to bind and activate complement.

1994 • 65 citations

The role of the carbohydrate chains in complement (C3) fixation by solid-phase-bound human IgA.

1994 • 63 citations

Mechanism and subcellular localization of secretory IgM polymer assembly.

1994 • 57 citations

Identification of a major binding site for complement C3 on the IgG1 heavy chain.

1993 • 56 citations

Monoclonal antibodies directed against gonococcal protein I vary in bactericidal activity.

1985 • 55 citations

Kinetic assessment of alternative complement pathway activity in a hemolytic system. II. Influence of antibody on alternative pathway activation.

1978 • 52 citations

Activation of human complement by mouse and mouse/human chimeric monoclonal antibodies

1993 • 52 citations

Glycosylation of IgA is required for optimal activation of the alternative complement pathway by immune complexes.

1994 • 49 citations

Human IgA1 initiates complement-mediated killing of Neisseria meningitidis.

1989 • 44 citations

Immunoglobulin M: Fixation of Human Complement by the Fc Fragment

1972 • 41 citations

All Forms of Human IgA Antibodies Bound to Antigen Interfere with Complement (C3) Fixation Induced by IgG or by Antigen Alone

1994 • 40 citations

Platelet-associated complement C3 in thrombocytopenic states

1983 • 37 citations

Kinetic Assessment of Alternative Complement Pathway Activity in A Hemolytic System

1978 • 37 citations

Mapping of amino acid residues in the C mu 3 domain of mouse IgM important in macromolecular assembly and complement-dependent cytolysis.

1994 • 37 citations

THE STRUCTURAL BASIS FOR BINDING OF COMPLEMENT BY IMMUNOGLOBULIN M

1974 • 37 citations

Complement activation by IgM: evidence for the importance of the third constant domain of the μ heavy chain

1987 • 36 citations

Inhibitory effect of igm rheumatoid factor on immune complex solubilization capacity and inhibition of immune precipitation

1984 • 31 citations

C1 binding by murine IgM. The effect of a Pro-to-Ser exchange at residue 436 of the mu-chain.

1988 • 31 citations

Human IgG preparations isolated by ion-exchange or protein G affinity chromatography differ in their glycosylation profiles

1993 • 31 citations

Putative Mechanisms of the Effect of Intravenous γ-Globulin

1993 • 29 citations

High doses of intravenous immunoglobulin do not affect the recognition phase of the classical complement pathway

1991 • 28 citations

C3 binds with similar efficiency to Fab and Fc regions of IgG immune aggregates

1994 • 28 citations

Complement fixation by model immune complexes free in solution and bound onto cell surfaces

1979 • 26 citations

Covalent binding of C3b to monoclonal antibodies selectively up‐regulates heavy chain epitope recognition by T cells

1994 • 21 citations

Complement activating properties of monoreactive and polyreactive IgM rheumatoid factors.

1993 • 21 citations

Human IgG3 is decreased and IgG1, IgG2 and IgG4 are unchanged in molecular size by mild reduction and reoxidation without any major change in effector functions

1993 • 16 citations

Clonal variations in complement activation and deposition of C3b and C4b on model immune complexes.

1993 • 13 citations

Complement-Mediated Lysis with Monoclonal Antibodies

1988 • 11 citations

IgM rheumatoid factor and the inhibition of covalent binding of C4b to IgG in immune complexes.

1993 • 10 citations

Interaction of serum IgA with complement components: the molecular basis of IgA blockade.

1987 • 10 citations

IgG inhibits the increase of platelet-associated C3 stimulated by anti-platelet antibodies

1993 • 10 citations

Interaction of immunoglobulin A with complement and phagocytic cells.

1989 • 8 citations

Kinetic Study of Rheumatoid Factor Influence on Complement-Mediated Modulation of Immune Precipitation

1985 • 4 citations

The Role of Antibody in the Activation of the Alternative Complement Pathway

1985 • 4 citations

Antibodies against rabbit red blood cells in murine serum and their effect on the activity of complement alternative pathway

1983 • 3 citations