Human IgG3 is decreased and IgG1, IgG2 and IgG4 are unchanged in molecular size by mild reduction and reoxidation without any major change in effector functions

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The molten globule state as a clue for understanding the folding and cooperativity of globular‐protein structure

1989 • 1,446 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Statistical Concepts and Methods

1980 • 717 citations

Evidence for a molten globule state as a general intermediate in protein folding

1990 • 677 citations

Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins

1989 • 466 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Immunoglobulin G: Functional sites

1985 • 442 citations

Statistical Concepts and Methods.

1978 • 429 citations

Crystallographic structure studies of an IgG molecule and an Fc fragment

1976 • 416 citations

Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: Results of an IUIS/WHO collaborative study

1985 • 393 citations

Human leukocyte IgG Fc receptors

1986 • 319 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

Native disulphide bond formation in protein biosynthesis: evidence for the role of protein disulphide isomerase

1984 • 293 citations

Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.

1988 • 269 citations

Disulphide bonds and protein stability

1988 • 261 citations

Human IgG subclass pattern of inducing complement‐mediated cytolysis depends on antigen concentration and to a lesser extent on epitope patchiness, antibody affinity and complement concentration

1991 • 173 citations

Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C_γgenes

1986 • 145 citations

The molten globule protein conformation probed by disulphide bonds

1991 • 143 citations

Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.

1977 • 136 citations

The IgG Subclass Pattern of Complement Activation Depends on Epitope Density and Antibody and Complement Concentration

1989 • 100 citations

Unusual Molecular Properties of Human IgG3 Proteins Due to an Extended Hinge Region

1974 • 76 citations

Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes.

1982 • 65 citations

Enhancement of Complement Activation and Cytolysis of Human IgG3 by Deletion of Hinge Exons

1990 • 63 citations

Conversion of incomplete antibodies to direct agglutinins by mild reduction: evidence for segmental flexibility within the Fc fragment of immunoglobulin G.

1977 • 59 citations

Three-dimensional structure of the Mcg IgG1 immunoglobulin☆

1983 • 56 citations

Mobile Fc region in the Zie IgG2 cryoglobulin: comparison of crystals of the F(ab')₂ fragment and the intact immunoglobulin

1978 • 54 citations

Characterization of Subclass‐related F(ab)₂. Fab/c and Fch Fragments Obtained by Short Papain Digestion of Human IgG Myeloma 312

1973 • 53 citations

Protein disulphide-isomerase: a homologue of thioredoxin implicated in the biosynthesis of secretory proteins

1988 • 53 citations

Antibody dependent cell-mediated cytotoxicity induced by chimeric mouse-human IgG subclasses and IgG3 antibodies with altered hinge region

1992 • 49 citations

The two binding‐site models of human IgG binding Fcγ receptors

1990 • 45 citations

The three-dimensional structure of a human IgGl immunoglobulin at 4 Å resolution: a computer fit of various structural domains on the electron density map

1982 • 26 citations

The solution shapes of IgG3 immunoglobulin and its Fch and Fc fragments. A small-angle x-ray scattering study

1980 • 21 citations

Conformation of the Hinge Region and Various Fragments of Human IgG3

1975 • 20 citations

The use of a hapten-Fab conjugate to sensitive target cells for antibody-dependent complement-mediated lysis and antibody-dependent cell-mediated cytotoxicity

1991 • 14 citations

Alteration of the conformation of human IgG subclasses by reduction of the hinge SS bonds

1988 • 14 citations

Unexpected interaction of some anti-TNP hybridoma antibodies with Superose HPLC gel filtration resins

1992 • 11 citations

Shared idiotypic determinant in mono- and polyclonal anti-phospholipid antibodies with lupus anticoagulant activity

1991 • 7 citations