Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation.

Sequences of proteins of immunological interest

1984 • 3,427 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

1987 • 615 citations

The binding site for C1q on IgG

1988 • 556 citations

Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region.

1989 • 519 citations

Immunoglobulin G: Functional sites

1985 • 442 citations

Localization of the binding site for the human high-affinity Fc receptor on IgG

1988 • 287 citations

Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies.

1988 • 281 citations

Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.

1988 • 269 citations

The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.

1991 • 261 citations

Correlation between segmental flexibility and effector function of antibodies

1984 • 235 citations

Effector functions of a monoclonal aglycosylated mouse IgG2a: Binding and activation of complement component C1 and interaction with human monocyte Fc receptor

1985 • 195 citations

The structure and function of immunoglobulin domains. IV. The distribution of some effector functions among the Cgamma2 and Cgamma3 homology regions of human immunoglobulin G1.

1976 • 165 citations

The C1q receptor site on immunoglobulin G

1980 • 161 citations

The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain.

1991 • 128 citations

Characterization of a plasmin-digest fragment of rabbit immunoglobulin gamma that binds antigen and complement

1975 • 126 citations

Influence of the hinge region on complement activation, C1q binding, and segmental flexibility in chimeric human immunoglobulins.

1990 • 123 citations

Expression of biological effector functions by immunoglobulin G molecules lacking the hinge region.

1981 • 100 citations

[32] Production and properties of chimeric antibody molecules

1989 • 85 citations

In Vitro Antibodies: Strategies for Production and Application

1992 • 85 citations

‘Sticky feet’-directed mutagenesis and its application to swapping antibody domains

1989 • 61 citations

Inhibition of C1-mediated immune hemolysis by monomeric and dimeric peptides from the second constant domain of human immunoglobulin G.

1981 • 44 citations

Isotypes of IgG: Comparison of the primary structures of three pairs of isotypes which differ in their ability to activate complement

1979 • 40 citations

[17] Oligonucleotide-directed mutagenesis: A simple method using two oligonucleotide primers and a single-stranded DNA template

1987 • 37 citations

Complement activation by IgM: evidence for the importance of the third constant domain of the μ heavy chain

1987 • 36 citations

Chimeric mouse human IgG3 antibodies with an IgG4‐like hinge region induce complement‐mediated lysis more efficiently than IgG3 with normal hing

1991 • 32 citations

Preparation and biologic characterization of fragments containing dimeric and monomeric Cγ2 domain of rabbit IgG

1985 • 20 citations