Residue at position 331 in the IgG1 and IgG4 CH2 domains contributes to their differential ability to bind and activate complement.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Antitrinitrophenyl (TNP) Plaque Assay. Primary Response of Balb/c Mice to Soluble and Particulate Immunogen

1969 • 935 citations

Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

1987 • 615 citations

The binding site for C1q on IgG

1988 • 556 citations

Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region.

1989 • 519 citations

Biological significance of carbohydrate chains on monoclonal antibodies.

1983 • 427 citations

Purification and radiolabeling of human C1q.

1981 • 295 citations

Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies.

1988 • 281 citations

Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.

1988 • 269 citations

Human Antibody Effector Function

1992 • 266 citations

Correlation between segmental flexibility and effector function of antibodies

1984 • 235 citations

Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling

1991 • 172 citations

The structure and function of immunoglobulin domains. IV. The distribution of some effector functions among the Cgamma2 and Cgamma3 homology regions of human immunoglobulin G1.

1976 • 165 citations

The binding of human complement component C4 to antibody-antigen aggregates

1980 • 162 citations

The C1q receptor site on immunoglobulin G

1980 • 161 citations

Ultracentrifuge studies of the binding of IgG of different subclasses to the Clq subunit of the first component of complement

1976 • 159 citations

The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement.

1975 • 154 citations

A protein structural change in aglycosylated IgG3 correlates with loss of huFcγR1 and hufcγR111 binding and/or activation

1990 • 128 citations

The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain.

1991 • 128 citations

Characterization of a plasmin-digest fragment of rabbit immunoglobulin gamma that binds antigen and complement

1975 • 126 citations

Influence of the hinge region on complement activation, C1q binding, and segmental flexibility in chimeric human immunoglobulins.

1990 • 123 citations

The Structure and Function of Immunoglobulin Domains

1976 • 107 citations

Expression of biological effector functions by immunoglobulin G molecules lacking the hinge region.

1981 • 100 citations

The Structure and Function of Immunoglobulin Domains

1975 • 87 citations

Functional affinity constants of the reaction between 125I-labelled C1q and C1q binders and their use in the measurement of plasma C1q concentrations.

1977 • 71 citations

Enhancement of Complement Activation and Cytolysis of Human IgG3 by Deletion of Hinge Exons

1990 • 63 citations

Immunoglobulin M possesses two binding sites for complement subcomponent C1q, and soluble 1:1 and 2:1 complexes are formed in solution at reduced ionic strength.

1985 • 45 citations

The improved lytic function and in vivo efficacy of monovalent monoclonal CD3 antibodies

1989 • 43 citations

Proton nuclear magnetic resonance studies of the structure of the Fc fragment of human immunoglobulin G1: Comparisons of native and recombinant proteins

1990 • 38 citations

C1q binding to chimeric monoclonal IgG3 antibodies consisting of mouse variable regions and human constant regions with shortened hinge containing 15 to 47 amino acids

1989 • 37 citations

Chimeric mouse human IgG3 antibodies with an IgG4‐like hinge region induce complement‐mediated lysis more efficiently than IgG3 with normal hing

1991 • 32 citations

Complement activation by immunoglobulin does not depend solely on C1q binding

1990 • 31 citations

C1 binding by murine IgM. The effect of a Pro-to-Ser exchange at residue 436 of the mu-chain.

1988 • 31 citations

Preparation and biologic characterization of fragments containing dimeric and monomeric Cγ2 domain of rabbit IgG

1985 • 20 citations

Isotype modulation of idiotypic expression in recombinant isotypic variants of MOPC 315.

1990 • 14 citations

Standing up for science

1983 • 3 citations