The role of cyclic AMP, calcium and filamentous actin in adenosine modulation of Fc receptor-mediated phagocytosis in human neutrophils

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

1987 • 524 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

Topics and Perspectives in Adenosine Research

1987 • 459 citations

The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.

1990 • 377 citations

Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors.

1992 • 361 citations

Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

1985 • 345 citations

Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils.

1990 • 229 citations

Intracellular Free Calcium Localization in Neutrophils During Phagocytosis

1985 • 217 citations

Ca2+-dependent and Ca2+-independent phagocytosis in human neutrophils

1985 • 211 citations

Adenosine receptors.

1992 • 196 citations

Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils.

1986 • 164 citations

Characterization of a Specific Adenosine Receptor on Human Lymphocytes

1978 • 130 citations

THE DEPRESSION OF PHAGOCYTOSIS BY EXOGENOUS CYCLIC NUCLEOTIDES, PROSTAGLANDINS, AND THEOPHYLLINE

1973 • 129 citations

Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory.

1990 • 126 citations

Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.

1985 • 124 citations

Inhibition by adenosine of reactive oxygen metabolite production by human polymorphonuclear leucocytes

1985 • 111 citations

The Microcomputer in Cell and Neurobiology Research

1986 • 97 citations

The effects of adenosine agonists on human neutrophil function.

1986 • 95 citations

Adenosine and adenosine receptors

1991 • 92 citations

Biophysical properties and microfilament assembly in neutrophils: modulation by cyclic AMP.

1991 • 91 citations

Actin dynamics in human neutrophils during adhesion and phagocytosis is controlled by changes in intracellular free calcium.

1993 • 88 citations

Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization

1988 • 85 citations

Receptor-mediated phagocytosis in human neutrophils is associated with increased formation of inositol phosphates and diacylglycerol. Elevation in cytosolic free calcium and formation of inositol phosphates can be dissociated from accumulation of diacylglycerol.

1989 • 84 citations

Protein kinase C and cAMP‐dependent protein kinase induce opposite effects on actin polymerizability

1987 • 83 citations

Cyclic AMP inhibition of phosphoinositide turnover in human neutrophils

1986 • 77 citations

Beta 2 integrin engagement triggers actin polymerization and phosphatidylinositol trisphosphate formation in non-adherent human neutrophils.

1993 • 76 citations

Compartmentalization of Cyclic AMP During Phagocytosis by Human Neutrophilic Granulocytes

1981 • 70 citations

Studies on molecular regulation of phagocytosis and activation of the NADPH oxidase in neutrophils. IgG- and C3b-mediated ingestion and associated respiratory burst independent of phospholipid turnover and Ca2+ transients.

1990 • 63 citations

Increased breakdown of phosphatidylinositol 4,5-bisphosphate is not an initiating factor for actin assembly in human neutrophils.

1988 • 58 citations

Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil

1992 • 55 citations

The protein kinase C activator phorbol‐12‐myristate‐13‐acetate enhances cyclic AMP accumulation in pheochromocytoma cells

1986 • 54 citations

Inhibition of inositol phospholipids metabolism and calcium mobilization by cyclic AMP-increasing agents and phorbol ester in neutrophils

1986 • 47 citations

Effects of adenosine on polymorphonuclear leucocyte function, cyclic 3′:5′‐adenosine monophosphate, and intracellular calcium

1989 • 34 citations

Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils

1991 • 33 citations

Does protein kinase C control receptor‐mediated phagocytosis in human neutrophils?

1988 • 32 citations

Regulation of oxygen radical production of human polymorphonuclear leukocytes by adenosine: the role of calcium

1992 • 31 citations

Coupling of antagonistic signalling pathways in modulation of neutrophil function

1989 • 30 citations

Leukocyte Activation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism

1987 • 28 citations

Effects of Adenosine on Inositol 1,4,5-Trisphosphate Formation and Intracellular Calcium Changes in Formyl-Met-Leu-Phe-Stimulated Human Neutrophils

1990 • 27 citations

Adenosine inhibits divalent cation influx across human neutrophil plasma membrane via surface adenosine A2 receptors

1992 • 24 citations

A novel principle for quantitation of fast intracellular calcium changes using Fura-2 and a modified image processing system — applications in studies of neutrophil motility and phagocytosis

1992 • 19 citations

A Wave of elevated intracellular free calcium spreads through human neutrophils during phagocytosis of zymosan

1992 • 18 citations

EFFECTS OF ADENOSINE AND ITS ANALOGUES ON ACTIN POLYMERIZATION IN HUMAN POLYMORPHONUCLEAR LEUCOCYTES

1993 • 11 citations