CCAAT/Enhancer-binding Protein δ Regulates Mammary Epithelial Cell G0 Growth Arrest and Apoptosis

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

The cell: a molecular approach

1997 • 1,616 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Genes specifically expressed at growth arrest of mammalian cells

1988 • 954 citations

Multiple hormone interactions in the developmental biology of the mammary gland.

1980 • 866 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene

1997 • 776 citations

The p53 Network

1998 • 731 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

1995 • 532 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

1992 • 413 citations

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

1996 • 393 citations

An essential role for C/EBPβ in female reproduction

1997 • 387 citations

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

1997 • 379 citations

Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.

1994 • 377 citations

Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβ

1997 • 340 citations

Interaction and functional collaboration of p300 and C/EBPβ

1997 • 339 citations

Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27.

1997 • 326 citations

Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α

1996 • 289 citations

The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland

1998 • 260 citations

C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland

1998 • 254 citations

The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1998 • 244 citations

p27Kip1 overexpression causes apoptotic death of mammalian cells

1997 • 228 citations

A Nuclear Factor for Interleukin-6 Expression (NF-IL6) and the Glucocorticoid Receptor Synergistically Activate Transcription of the Rat α1-Acid Glycoprotein Gene via Direct Protein-Protein Interaction

1993 • 215 citations

Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.

1996 • 213 citations

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.

1994 • 207 citations

p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin.

1995 • 167 citations

Regulation of Cyclin D1 by Calpain Protease

1997 • 159 citations

Insulin Regulates Transcription of the CCAAT/Enhancer Binding Protein (C/EBP) α , β , and δ Genes in Fully-differentiated 3T3-L1 Adipocytes

1995 • 157 citations

A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.

1997 • 153 citations

Induction of apoptosis by the tumor suppressor protein BRCA1.

1996 • 140 citations

Cyclin D1 Triggers Autonomous Growth of Breast Cancer Cells by Governing Cell Cycle Exit

1996 • 129 citations

Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue.

1994 • 129 citations

Role of the CCAAT/Enhancer Binding Protein-α Transcription Factor in the Glucocorticoid Stimulation of p21 Gene Promoter Activity in Growth-arrested Rat Hepatoma Cells

1998 • 122 citations

Tumor Necrosis Factor α Promotes Nuclear Localization of Cytokine-inducible CCAAT/Enhancer Binding Protein Isoforms in Hepatocytes

1996 • 104 citations

Differential Patterns of Expression of Three C/EBP Isoforms, HNF-1, and HNF-4 after Partial Hepatectomy in Rats

1993 • 91 citations

ATF-2 and C/EBPα Can Form a Heterodimeric DNA Binding Complex in Vitro

1997 • 86 citations

The role of p27Kip1 in gamma interferon-mediated growth arrest of mammary epithelial cells and related defects in mammary carcinoma cells

1997 • 86 citations

CCAAT/Enhancer-binding Protein-δ (C/EBP-δ) Is Induced in Growth-arrested Mouse Mammary Epithelial Cells

1997 • 80 citations

CCAAT/Enhancer-binding Protein δ Activates Insulin-like Growth Factor-I Gene Transcription in Osteoblasts

1997 • 75 citations

Cell Cycle-Dependent Phosphorylation of p27 Cyclin-Dependent Kinase (Cdk) Inhibitor by Cyclin E/Cdk2

1997 • 75 citations

Transcription of Cystic Fibrosis Transmembrane Conductance Regulator Requires a CCAAT-like Element for both Basal and cAMP-mediated Regulation

1995 • 70 citations

β-Adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT/enhancer-binding protein δ

1998 • 62 citations

Overexpression of cyclin E in the HC11 mouse mammary epithelial cell line is associated with growth inhibition and increased expression of p27(Kip1).

1996 • 60 citations

Lactation status influences expression of CCAAT/enhancer binding protein isoform mRNA in the mouse mammary gland

1998 • 58 citations

Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence

1998 • 52 citations

CCAAT/Enhancer-Binding Protein Gene Expression Is Mediated by APRF/STAT3

1997 • 52 citations

Transcription Factor C/EBPδ in Fetal Lung: Developmental Regulation and Effects of Cyclic Adenosine 3′,5′-Monophosphate and Glucocorticoids*

1997 • 51 citations

Overexpression of p27Kip1 inhibits the growth of both normal and transformed human mammary epithelial cells.

1998 • 43 citations

Expression of the genes encoding CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution

1998 • 42 citations

Regulation of CCAAT/Enhancer Binding Protein Isoforms by Serum and Glucocorticoids in the Rat Intestinal Epithelial Crypt Cell Line IEC-6

1996 • 37 citations

Activation of CAAT Enhancer-binding Protein δ (C/EBPδ) by Interleukin-1 Negatively Influences Apolipoprotein C-III Expression

1997 • 30 citations

Growth Suppression of Normal Mammary Epithelial Cells by Wild‐Type p53

1993 • 11 citations