Expression of MDM2 during mammary tumorigenesis

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The MDM2 gene amplification database

1998 • 958 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

1996 • 272 citations

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1995 • 271 citations

Mdm2: keeping p53 under control

1997 • 267 citations

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1997 • 236 citations

The mammary gland: A unique organ for the study of development and tumorigenesis

1996 • 188 citations

Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status

1995 • 125 citations

Abnormal expression of MDM-2 in breast carcinomas

1996 • 104 citations

Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases

1997 • 103 citations

MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.

1995 • 76 citations

Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells.

1995 • 74 citations

Infrequent p53 mutations in 7,12‐dimethylbenz[a]anthracene–induced mammary tumors in BALB/c and p53 hemizygous mice

1994 • 56 citations

A MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF THE MDM2 PROTEIN ISOFORMS ANDp53 GENE PRODUCT IN BRONCHOGENIC CARCINOMA

1996 • 45 citations

Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics.

1996 • 25 citations

Genomic organization of the mouse double minute 2 gene

1996 • 23 citations