The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery

1987 • 558 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.

1982 • 552 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.

1992 • 521 citations

Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations

1991 • 500 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

The MARCKS family of cellular protein kinase C substrates.

1993 • 484 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

RACE: RAPID AMPLIFICATION OF cDNA ENDS

1990 • 412 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Ultraviolet radiation directly induces pigment production by cultured human melanocytes

1987 • 311 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Keeping track of neurotrophin receptors

1991 • 297 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

1986 • 275 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

Evidence for nerve growth factor-mediated paracrine effects in human epidermis.

1991 • 202 citations

Neurotrophin 3 is a mitogen for cultured neural crest cells.

1992 • 192 citations

Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture.

1993 • 190 citations

Selective Cultivation of Human Melanocytes from Newborn and Adult Epidermis

1984 • 189 citations

Growth-regulated synthesis and secretion of biologically active nerve growth factor by human keratinocytes.

1991 • 176 citations

trkB, a Neural Receptor Protein-Tyrosine Kinase: Evidence for a Full-Length and Two Truncated Receptors

1991 • 131 citations

Molecular and Biochemical Characterization of the Human trk Proto-Oncogene

1989 • 124 citations

Neurotrophin-3: a neurotrophic factor related to NGF and BDNF

1990 • 122 citations

Human Melanocyte Growth and Differentiation: A Decade of New Data

1991 • 121 citations

The nerve growth factor: Thirty-five years later

1987 • 119 citations

Expression and modulation of nerve growth factor in murine keratinocytes (PAM 212).

1990 • 118 citations

Pigment content of cultured human melanocytes does not correlate with tyrosinase message level

1991 • 113 citations

NGF in CNS: Experimental data and clinical implications

1989 • 97 citations

Induction of nerve growth factor receptors on cultured human melanocytes.

1988 • 92 citations

Calcium, cyclic AMP and protein kinase C ? partners in mitogenesis

1987 • 86 citations

Transcriptional activation of immunoglobulin α heavy-chain genes by translocation of the c-myc oncogene

1983 • 84 citations

Relationship between Actinic Damage and Chronologic Aging in Keratinocyte Cultures of Human Skin

1979 • 82 citations

Hormone- and phorbol ester-activated protein kinase C isozymes mediate a reorganization of the actin cytoskeleton associated with prolactin secretion in GH4C1 cells.

1992 • 82 citations

The Melanocyte: Its Structure, Function, and Subpopulations in Skin, Eyes, and Hair

1988 • 74 citations

Prior Chronic Sun Exposure Decreases the Lifespan of Human Skin Fibroblasts in Vitro

1980 • 68 citations

Phosphorylation of neurofilament proteins by protein kinase C

1988 • 67 citations

Protective effect of alpha-tocopherol in carrier liposomes on ultraviolet-mediated human epidermal cell damage in vitro.

1991 • 67 citations

Phosphorylation of ras oncogene product by protein kinase C

1987 • 45 citations

Protein kinase C‐induced redistribution of the cytoskeleton and phosphorylation of vimentin in cultured brain macrophages

1991 • 43 citations

Hormone- and phorbol ester-activated protein kinase C isozymes mediate a reorganization of the actin cytoskeleton associated with prolactin secretion in GH4C1 cells

1992 • 38 citations

Intracellular localization of types i and ii collagen mrna and endoplasmic reticulum in embryonic corneal epithelia

1991 • 26 citations

Fresh factors to consider

1991 • 24 citations

Embryonic corneal epithelial actin alters distribution in response to laminin.

1992 • 19 citations

Dissociation of proto‐oncogene induction from growth response in normal human fibroblasts

1990 • 12 citations