NGF in CNS: Experimental data and clinical implications

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Nerve growth factor.

1968 • 2,025 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

1983 • 725 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Induction of nerve growth factor receptor in Schwann cells after axotomy.

1986 • 614 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Transplantation of adrenal medullary tissue to striatum in parkinsonism

1985 • 601 citations

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

1984 • 598 citations

The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery

1987 • 558 citations

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

1986 • 528 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

1988 • 508 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

Human β-nerve growth factor gene sequence highly homologous to that of mouse

1983 • 486 citations

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

1985 • 483 citations

Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor

1983 • 474 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Nerve Growth Factor Gene Expression in the Developing Rat Brain

1986 • 436 citations

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

1979 • 422 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

1988 • 356 citations

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease

1986 • 335 citations

Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons

1989 • 331 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

Nerve growth factors in the rat iris

1980 • 297 citations

Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures

1982 • 291 citations

Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain

1986 • 289 citations

Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior

1985 • 259 citations

Expression of NGF receptor in the developing and adult primate central nervous system

1988 • 251 citations

Developmental and regional expression of β-nerve growth factor receptor mRNA in the chick and rat

1988 • 245 citations

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

1989 • 241 citations

Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

1987 • 237 citations

Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment

1988 • 213 citations

Grafting genetically modified cells to the brain: Possibilities for the future

1987 • 206 citations

Dynamics of Degeneration and Growth in Neurons

1974 • 196 citations

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

1986 • 188 citations

In Vitro Evidence for Two Distinct Hippocampal Growth Factors: Basis of Neuronal Plasticity?

1982 • 177 citations

Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes

1988 • 176 citations

Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodent upon intracerebral NGF injections.

1978 • 173 citations

Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions

1985 • 172 citations

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

1989 • 171 citations

The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo.

1985 • 163 citations

Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.

1987 • 157 citations

The role of nerve growth factor in the CNS

1986 • 153 citations

Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: Comparison with choline acetyltransferase

1987 • 152 citations

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

1988 • 151 citations

Cell death of motoneurons in the chick embryo spinal cord. VI. Reduction of naturally occurring cell death in the thoracolumbar column of terni by nerve growth factor

1982 • 147 citations

Differential expression of the nerve growth factor receptor gene in multiple brain areas

1988 • 146 citations

Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats

1986 • 144 citations

Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord

1988 • 134 citations

Increased beta-nerve growth factor messenger RNA and protein levels in neonatal rat hippocampus following specific cholinergic lesions

1987 • 132 citations

Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease

1989 • 130 citations

Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons

1988 • 128 citations

Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro

1988 • 122 citations

Structure and expression of the chicken beta nerve growth factor gene.

1986 • 121 citations

Neurotrophic activity in the adult rat hippocampal formation: regional distribution and increase after septal lesion

1985 • 118 citations

Nerve growth factor mRNA in brain: Localization by in situ hybridization

1986 • 110 citations

Immunohistochemical localization of cells containing nerve growth factor receptors in the different regions of the adult rat forebrain

1988 • 108 citations

Nerve growth factor binding in aged rat central nervous system: Effect of acetyl‐l‐carnitine

1988 • 108 citations

Nerve growth factor receptors in the central nervous system

1988 • 106 citations

Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain

1988 • 102 citations

Alzheimer's Disease

1985 • 87 citations

Nerve growth factor (NGF) receptor expression in chicken cranial development

1987 • 85 citations

Purkinje cells of adult rat cerebellum express nerve growth factor receptor immunoreactivity: light microscopic observations

1988 • 84 citations

Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles.

1985 • 76 citations

NGF treatment promotes development of basal forebrain tissue grafts in the anterior chamber of the eye

1989 • 76 citations

Localization of nerve growth factor-like immunoreactivity in rat nervous tissue.

1983 • 73 citations

Highly sensitive enzyme immunoassays for β-nerve growth factor

1987 • 73 citations

Intrahippocampal injections of antiserum to nerve growth factor inhibit sympathohippocampal sprouting

1985 • 72 citations

Fimbria-fornix lesion increases nerve growth factor content in adult rat septum and hippocampus

1986 • 72 citations

NGF receptor immunoreactivity in rat brain: Topographic distribution and response to entorhinal ablation

1987 • 71 citations

NGF receptor immunoreactivity in aged rat brain

1989 • 66 citations

The role of nerve-growth factor (NGF) in the central nervous system

1976 • 61 citations

NGF and Anti-NGF: Evidence against Effects on Fiber Growth in Locus coeruleus from Cultures of Perinatal CNS Tissues

1979 • 51 citations

Chapter 3 Developmental appearance of nerve growth factor in the rat brain: significant deficits in the aged forebrain

1988 • 42 citations

Effect of bilateral decortication on nerve growth factor content in basal nucleus and neostriatum of adult rat brain

1988 • 42 citations

Retrograde transport of nerve growth factor in lesioned goldfish retinal ganglion cells.

1983 • 38 citations

Nerve growth factor stimulates neurite outgrowth from goldfish retinal explants: The influence of a prior lesion

1982 • 37 citations

Nerve Growth Factor (NGF) receptors in the central nervous system

1987 • 37 citations

Retrograde transport of nerve growth factor in lesioned goldfish retinal ganglion cells

1983 • 34 citations

HAS NERVE GROWTH FACTOR A ROLE IN THE REGENERATION OF CENTRAL AND PERIPHERAL CATECHOLAMINE NEURONS?

1974 • 25 citations

Retrograde transport of nerve growth factor in the rat central nervous system

1978 • 22 citations

Nerve growth factor promotes survival of retrogradely labeled hippocampus-projecting neurons in the rat basal forebrain in vitro

1989 • 21 citations