Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Thresholds of focal cerebral ischemia in awake monkeys

1981 • 1,144 citations

Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments

1985 • 663 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro

1985 • 464 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 • 302 citations

MK-801 protects the neonatal brain from hypoxic-ischemic damage

1987 • 261 citations

The importance of avoiding ?dark? neurons in experimental neuropathology

1961 • 259 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope.

1968 • 199 citations

Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia

1987 • 184 citations

Systemic administration of MK-801 prevents neuronal degeneration in rat brain

1987 • 134 citations

Neurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats.

1986 • 99 citations

Pial arterial pressure in cats following middle cerebral artery occlusion. 1. Relationship to blood flow, regulation of blood flow and electrophysiological function.

1983 • 54 citations

Training in neurological surgery. The Charles A. Elsberg memorial lecture.

1967 • 1 citations