Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat

Statistical power analysis for the behavioral sciences

1990 • 65,781 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Statistical Power Analysis for the Behavioral Sciences

1977 • 2,262 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Autoregulation of Brain Circulation in Severe Arterial Hypertension

1973 • 854 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Epidemiologic Assessment of the Role of Blood Pressure in Stroke

1970 • 671 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

1989 • 516 citations

Focal Brain Ischemia in the Rat: Methods for Reproducible Neocortical Infarction Using Tandem Occlusion of the Distal Middle Cerebral and Ipsilateral Common Carotid Arteries

1988 • 488 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia

1988 • 245 citations

Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia

1988 • 244 citations

The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats

1991 • 239 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

Kynurenate inhibition of cell excitation decreases stroke size and deficits

1987 • 189 citations

Autoregulation of Cerebral Blood Flow in Experimental Focal Brain Ischemia

1990 • 177 citations

Dextromethorphan reduces neocortical ischemic neuronal damage in vivo

1988 • 131 citations

Neurology and Neurobiology

1990 • 123 citations

Morphometric study on cerebral vessels in spontaneously hypertensive rats.

1980 • 112 citations

Cerebral Blood Flow in Rats with Renal and Spontaneous Hypertension: Resetting of the Lower Limit of Autoregulation

1982 • 110 citations

Long-Term Development of Selective Neuronal Loss and the Mechanism of Protection by 2-Amino-7-Phosphonoheptanoate in a Rat Model of Incomplete Forebrain Ischaemia

1988 • 102 citations

Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia

1988 • 102 citations

Neurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats.

1986 • 99 citations

Continuous Nimodipine Treatment Attenuates Cortical Infarction in Rats Subjected to 24 Hours of Focal Cerebral Ischemia

1990 • 97 citations

Effect of the NMDA Antagonist MK-801 on Local Cerebral Blood Flow in Focal Cerebral Ischaemia in the Rat

1989 • 93 citations

Risk factors in stroke.

1985 • 88 citations

Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.

1988 • 76 citations

Effects of MK-801 upon Local Cerebral Glucose Utilisation in Conscious Rats and in Rats Anaesthetised with Halothane

1989 • 76 citations

Pre- and Post-Ischemic Administration of Dizocilpine (MK-801) Reduces Cerebral Necrosis in the Rat

1989 • 73 citations

Disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine in rats, dogs, and monkeys.

1983 • 72 citations

MK-801, an Excitatory Amino Acid Antagonist, Does Not Improve Neurologic Outcome following Cardiac Arrest in Cats

1989 • 67 citations

Cerebral infarction after middle cerebral artery occlusion in progenies of spontaneously stroke-prone and normal rats.

1984 • 62 citations

Evaluation of the glutamate antagonist dizocilipine maleate (MK-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology

1989 • 56 citations

Immunohistochemical Determination of Calcium—Calmodulin Binding Predicts Neuronal Damage after Global Ischemia

1989 • 56 citations

KETAMINE FAILS TO PROTECT AGAINST ISCHAEMIC NEURONAL NECROSIS IN THE RAT

1988 • 45 citations

Effects of Halothane on Regional Cerebral Blood Flow in Experimental Focal Ischemia

1973 • 22 citations