The neuroprotective action of dizocilpine (MK‐801) in the rat middle cerebral artery occlusion model of focal ischaemia

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

1981 • 1,420 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Delayed hippocampal damage in humans following cardiorespiratory arrest

1987 • 710 citations

Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments

1985 • 663 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Dynamics of Extracellular Metabolites in the Striatum after Middle Cerebral Artery Occlusion in the Rat Monitored by Intracerebral Microdialysis

1989 • 350 citations

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 • 302 citations

Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion.

1990 • 276 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3

1989 • 249 citations

Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path

1985 • 247 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia

1988 • 244 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia

1988 • 192 citations

Kynurenate inhibition of cell excitation decreases stroke size and deficits

1987 • 189 citations

Mechanisms of brain damage in focal cerebral ischemia

1988 • 166 citations

Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor

1989 • 154 citations

Focal Cerebral Ischemia in the Cat: Pretreatment with a Competitive NMDA Receptor Antagonist, D-CPP-ene

1990 • 111 citations

A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat

1987 • 109 citations

Calcium Uptake Evoked by Electrical Stimulation is Enhanced Postischemically and Precedes Delayed Neuronal Death in CA1 of Rat Hippocampus: Involvement of N-Methyl-D-Aspartate Receptors

1988 • 106 citations

Cell Damage in the Brain: A Speculative Synthesis

1984 • 100 citations

Effect of the NMDA Antagonist MK-801 on Local Cerebral Blood Flow in Focal Cerebral Ischaemia in the Rat

1989 • 93 citations

Pure cortical ischemia versus striatal ischemia. Circulatory, metabolic, and neuropathologic consequences

1985 • 72 citations

Disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine in rats, dogs, and monkeys.

1983 • 72 citations

The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures

1990 • 66 citations

Cardiovascular effects of the N-methyl-D-aspartate receptor antagonist MK-801 in conscious rats.

1989 • 59 citations

KETAMINE FAILS TO PROTECT AGAINST ISCHAEMIC NEURONAL NECROSIS IN THE RAT

1988 • 45 citations

Plasma and CSF levels of dizocilplne (MK-801) required for neuroprotection in the quinolinate-injected rat striatum

1991 • 19 citations

A Radioimmunoassay for the Anticonvulsant and Neuroprotective Agent, MK-801%

1990 • 6 citations

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