Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells

Angiogenesis.

1992 • 2,581 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

The Ets family of transcription factors

1993 • 848 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

1992 • 530 citations

A putative second cell-derived oncogene of the avian leukaemia retrovirus E26

1983 • 462 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Tripartite structure of the avian erythroblastosis virus E26 transforming gene

1983 • 430 citations

Spontaneous transformation and immortalization of human endothelial cells

1990 • 428 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

1996 • 351 citations

Ras-Mediated Phosphorylation of a Conserved Threonine Residue Enhances the Transactivation Activities of c-Ets1 and c-Ets2

1996 • 325 citations

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.

1996 • 306 citations

Plasminogen activator and collagenase production by cultured capillary endothelial cells

1982 • 279 citations

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

1983 • 261 citations

elk , Tissue-Specific ets -Related Genes on Chromosomes X and 14 Near Translocation Breakpoints

1989 • 261 citations

Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

1988 • 248 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.

1992 • 242 citations

The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.

1993 • 228 citations

Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis.

1994 • 201 citations

Urokinase‐type plasminogen activator mediates basic fibroblast growth factor‐induced bovine endothelial cell migration independent of its proteolytic activity

1992 • 183 citations

Evolutionarily conserved Ets family members display distinct DNA binding specificities.

1992 • 175 citations

The erg gene: a human gene related to the ets oncogene.

1987 • 164 citations

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

1995 • 163 citations

Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.

1992 • 160 citations

Endothelial-specific gene expression directed by the tie gene promoter in vivo

1995 • 158 citations

Complementary patterns of expression of c-ets 1, c-myb and c-myc in the blood-forming system of the chick embryo

1989 • 147 citations

Stromal expression of c-Ets1 transcription factor correlates with tumor invasion.

1994 • 141 citations

A Novel Promoter for Vascular Endothelial Growth Factor Receptor (flt-1) That Confers Endothelial-specific Gene Expression

1995 • 130 citations

A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells.

1992 • 126 citations

Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1.

1994 • 120 citations

Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals.

1995 • 116 citations

Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.

1986 • 114 citations

junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2.

1994 • 105 citations

Indispensable Role of Tissue-Type Plasminogen Activator in Growth Factor-Dependent Tube Formation of Human Microvascular Endothelial Cells in Vitro

1993 • 104 citations

Myb and Ets Proteins Cooperate to Transactivate an Early Myeloid Gene

1995 • 101 citations

Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells*1

1988 • 98 citations

The proto-oncogene c-ets is preferentially expressed in lymphoid cells.

1985 • 98 citations

Angiogenic growth factors in neural embryogenesis and neoplasia.

1995 • 94 citations

Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophils

1987 • 92 citations

Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells.

1994 • 87 citations

Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of theetsoncogene family

1993 • 85 citations

A role of fibrinolytic activity in angiogenesis. Quantitative assay using in vitro method.

1989 • 78 citations

The human ETS1 gene: genomic structure, promoter characterization and alternative splicing.

1991 • 74 citations

The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors.

1990 • 62 citations

Expression of C-ETS1 in Early Chick Embryo Mesoderm: Relationship to the Hemangioblastic Lineage

1993 • 60 citations

Decreased response to epidermal growth factor during cellular senescence in cultured human microvascular endothelial cells

1992 • 52 citations