Clinical Uses of Antiestrogens

A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

1989 • 1,471 citations

Endometrial Cancer in Tamoxifen-Treated Breast Cancer Patients: Findings From the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14 *

1994 • 1,259 citations

Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast Cancer

1992 • 1,139 citations

Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case -Control Studies

1992 • 995 citations

Ovarian Tumors in a Cohort of Infertile Women

1994 • 706 citations

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.

1994 • 614 citations

Risk of endometrial cancer after tamoxifen treatment of breast cancer

1994 • 574 citations

Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trial

1994 • 531 citations

Adjuvant Tamoxifen Therapy for Early Stage Breast Cancer and Second Primary Malignancies

1995 • 515 citations

Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

1990 • 419 citations

Use of tamoxifen for breast cancer: twenty-eight years later.

1995 • 417 citations

Endocrine Pharmacology of Antiestrogens as Antitumor Agents*

1990 • 403 citations

Venous and arterial thrombosis in patients who received adjuvant therapy for breast cancer.

1991 • 399 citations

PROGNOSTIC ASSESSMENT OF FEMALE FECUNDITY

1987 • 395 citations

Potential Role of Tamoxifen in Prevention of Breast Cancer

1991 • 387 citations

Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women

1991 • 380 citations

Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial. The Scottish Breast Cancer Committee.

1991 • 367 citations

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

1995 • 351 citations

High-grade endometrial carcinoma in tamoxifen-treated breast cancer patients.

1993 • 347 citations

Cardiac and Thromboembolic Morbidity Among Postmenopausal Women With Early Stage Breast Cancer in a Randomized Trial of Adjuvant Tamoxifen

1993 • 339 citations

Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women After 5 Years of Treatment

1994 • 279 citations

Symptoms Associated With Tamoxifen Treatment in Postmenopausal Women

1991 • 276 citations

Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats.

1993 • 268 citations

A decade’s experience with an individualized clomiphene treatment regimen including its effect on the postcoital test

1982 • 267 citations

Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case-Control Studies

1992 • 261 citations

Clomiphene citrate: mechanism(s) and site(s) of action—a hypothesis revisited

1984 • 246 citations

Antagonism of estrogen action with a new benzothiophene derived antiestrogen

1983 • 244 citations

Treatment of Metastatic Malignant Melanoma with Dacarbazine plus Tamoxifen

1992 • 241 citations

ICI 182,780, a new antioestrogen with clinical potential

1992 • 240 citations

Endometrial changes in postmenopausal breast cancer patients receiving tamoxifen.

1993 • 230 citations

The agonistic-antagonistic properties of clomiphene: A review

1981 • 222 citations

Tamoxifen and bone metabolism in postmenopausal low-risk breast cancer patients: a randomized study.

1994 • 199 citations

Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity a prospective study of 63 patients

1992 • 196 citations

Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels

1983 • 177 citations

Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin

1993 • 172 citations

A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis

1991 • 171 citations

A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis

1990 • 169 citations

Effect of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years

1994 • 169 citations

Factors affecting the pregnancy rate in clomiphene citrate induction of ovulation.

1983 • 167 citations

Tamoxifen Use in Breast Cancer Patients Who Subsequently Develop Corpus Cancer Is Not Associated with a Higher Incidence of Adverse Histologic Features

1994 • 163 citations

Unusual ultrasonographic appearance of the uterus in patients receiving tamoxifen

1994 • 158 citations

Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract

1987 • 157 citations

Prediction of individual response to controlled ovarian hyperstimulation by means of a clomiphene citrate challenge test

1990 • 157 citations

The Royal Marsden Hospital pilot tamoxifen chemoprevention trial

1994 • 156 citations

Endocrine effects of adjuvant chemotherapy and long-term tamoxifen administration on node-positive patients with breast cancer.

1987 • 154 citations

EFFECT OF THE ANTI-OESTROGEN TAMOXIFEN ON PLASMA LEVELS OF LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE, PROLACTIN, OESTRADIOL AND PROGESTERONE IN NORMAL PRE-MENOPAUSAL WOMEN

1976 • 154 citations

Tamoxifen and estrogen lower circulating lipoprotein(a) concentrations in healthy postmenopausal women.

1994 • 152 citations

Evidence for a Hypothalamic Site of Action of Clomiphene Citrate in Women*

1985 • 151 citations

Tamoxifen, serum lipoproteins and cardiovascular risk

1988 • 147 citations

Alteration of Endocrine Parameters in Premenopausal Women With Breast Cancer During Long-Term Adjuvant Therapy With Tamoxifen as the Single Agent

1991 • 147 citations

Descriptive Clinicopathologic Study of 17 Patients With Endometrial Cancer During or After Adjuvant Tamoxifen in Early Breast Cancer

1993 • 147 citations

Clinical and laboratory predictors of clomiphene response

1982 • 145 citations

Endocrine Consequences of Continuous Antiestrogen Therapy with Tamoxifen in Premenopausal Women

1979 • 144 citations

A Prospective Evaluation of Clomiphene Citrate Challenge Test Screening of the General Infertility Population

1993 • 143 citations

Estrogen-Like Action of Tamoxifen on Vaginal Epithelium in Breast Cancer Patients

1981 • 138 citations

Action of ?pure? antiestrogens in inhibiting estrogen receptor action

1993 • 135 citations

The future of new pure antiestrogens in clinical breast cancer

1993 • 133 citations

Molecular mechanisms of antiestrogen action in breast cancer

1994 • 130 citations

A randomized study of dexamethasone in ovulation induction with clomiphene citrate

1984 • 128 citations

Comparison of the effectiveness of placebo, clomiphene citrate, mesterolone, pentoxifylline, and testosterone rebound therapy for the treatment of idiopathic oligospermia

1983 • 128 citations

Adjuvant tamoxifen in primary breast cancer: Influence on plasma lipids and antithrombin III levels

1988 • 125 citations

Long-term adjuvant therapy with tamoxifen: effects on sex hormone binding globulin and antithrombin III.

1987 • 124 citations

Tamoxifen in premenopausal patients with metastatic breast cancer: a review.

1991 • 122 citations

Tamoxifen enhances cell death in implanted MCF7 breast cancer by inhibiting endothelium growth.

1994 • 121 citations

Relationship of Weight to Successful Induction of Ovulation with Clomiphene Citrate

1979 • 120 citations

Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats.

1995 • 117 citations

Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances

1994 • 116 citations

Desmoid tumours treated with triphenylethylenes

1992 • 111 citations

Evaluation of clomiphene citrate and human chorionic gonadotropin treatment: a prospective, randomized, crossover study during intrauterine insemination cycles

1994 • 111 citations

Endometrial Changes with Tamoxifen: Comparison between Tamoxifen-Treated and Nontreated Asymptomatic, Postmenopausal Breast Cancer Patients

1994 • 108 citations

The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume.

1989 • 104 citations

Mechanisms of antihormone action

1992 • 104 citations

Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles

1991 • 103 citations

Ovulation and Pregnancy Rates With Clomiphene Citrate

1978 • 101 citations

Prediction of response to controlled ovarian hyperstimulation: a comparison of basal and clomiphene citrate-stimulated follicle-stimulating hormone levels

1992 • 100 citations

The effect of therapy initiation day on clomiphene citrate therapy

1989 • 99 citations

Toremifene and tamoxifen in advanced breast cancer - a double-blind cross-over trial

1993 • 98 citations

Unexplained infertility: evaluation of treatment with clomiphene citrate and human chorionic gonadotropin

1989 • 95 citations

A controlled comparison of the efficacy of clomiphene citrate in male infertility

1988 • 93 citations

Oncogenic potential of tamoxifen on endometria of postmenopausal women with breast cancer—Preliminary report

1991 • 89 citations

Clomiphene and dexamethasone in women unresponsive to clomiphene alone.

1982 • 88 citations

Intrauterine insemination does and clomiphene citrate does not improve fecundity in couples with infertility due to male or idiopathic factors: a prospective, randomized, controlled study

1990 • 87 citations

Alternative mechanisms of action of anti-oestrogens

1994 • 85 citations

Hysteroscopic follow-up during Tamoxifen treatment

1990 • 85 citations

Endometrial changes in postmenopausal women treated with tamoxifen for breast cancer

1993 • 84 citations

Droloxifene, a new antiestrogen: Its role in metastatic breast cancer

1994 • 82 citations

Rapid growth of leiomyoma in patient receiving tamoxifen

1992 • 78 citations

Clomiphene treatment for women with unexplained infertility: placebo-controlled study of hormonal responses and conception rates

1990 • 78 citations

The Effect of Clomiphene Citrate on Different Sperm Parameters and Serum Hormone Levels in Preselected Infertile Men: A Controlled Double‐Blind Cross‐Over Study

1980 • 78 citations

Effect of long-term tamoxifen therapy on cancellous bone remodeling and structure in women with breast cancer

1994 • 77 citations

Hypothalamic-pituitary-ovarian response to clomiphene citrate in women with polycystic ovary syndrome

1993 • 77 citations

Congenital malformations of newborn infants after clomiphene-induced ovulation

1983 • 76 citations

Clomiphene citrate affects cervical mucus and endometrial morphology independently of the changes in plasma hormonal levels induced by multiple follicular recruitment

1993 • 76 citations

Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12-dimethylbenzanthracene-induced rat mammary carcinoma model.

1987 • 74 citations

11β-Amidoalkoxyphenyl estradiols, a new series of pure antiestrogens

1994 • 72 citations

Symptoms associated with tamoxifen treatment in postmenopausal women

1991 • 70 citations

An extended regimen of clomiphene citrate in women unresponsive to standard therapy

1982 • 68 citations

Visual Disturbance Secondary to Clomiphene Citrate

1995 • 67 citations

Comparison of natural with clomiphene citrate-stimulated cycles in in vitro fertilization: a prospective, randomized trial

1994 • 66 citations

Tamoxifen for the Primary Prevention of Breast Cancer: A Review and Critique of the Concept and Trial

1993 • 64 citations

Hypothalamic-pituitary-ovarian response to clomiphene citrate in women with polycystic ovary syndrome.

1993 • 63 citations

Sequential clomiphene citrate and human menopausal gonadotrophin for ovulation induction: comparison to clomiphene citrate alone and human menopausal gonadotrophin alone

1993 • 61 citations

An individualized graduated therapeutic regimen for clomiphene citrate

1974 • 60 citations

Gynaecological monitoring during tamoxifen therapy

1994 • 58 citations

Induction of luteal phase defect with clomiphene citrate

1984 • 58 citations

Clomiphene citrate therapy for luteal phase defect

1983 • 54 citations

11β-Amidoalkyl estradiols, a new series of pure antiestrogens

1992 • 53 citations

Maturation of Vaginal and Endometrial Epithelium in Postmenopausal Breast Cancer Patients Receiving Long-Term Tamoxifen

1994 • 53 citations

Thyroid function test changes with adjuvant tamoxifen therapy in postmenopausal women with breast cancer.

1995 • 52 citations

Effect of Clomiphene Citrate in Polycystic Ovary Syndrome: Relationship Between Serum Gonadotropin and Corpus Luteum Function

1970 • 52 citations

Luteal phase deficiency: Effect of treatment on pregnancy rates

1992 • 50 citations

Comparison between tamoxifen and clomiphene for induction of ovulation.

1982 • 49 citations

Anti-oestrogenic and anti-tumour properties of prolonged tamoxifen therapy in C3H/OUJ mice

1990 • 49 citations

Effect of clomiphene citrate upon amount and duration of human menopausal gonadotropin therapy

1976 • 48 citations

The effect of clomiphene citrate and menopausal gonadotropins on cervical mucus in ovulatory cycles

1993 • 47 citations

Advanced secretory changes in the proliferative human endometrial epithelium following clomiphene citrate treatment

1986 • 44 citations

Effects of tamoxifen adjuvant therapy and a low-fat diet on serum binding proteins and estradiol bioavailability in postmenopausal breast cancer patients.

1992 • 42 citations

Infertility: Corpus luteum function and pregnancy rates with clomiphene citrate therapy: comparison of human chorionic gonadotrophin-induced versus spontaneous ovulation*

1995 • 42 citations

Effect of clomiphene citrate treatment on endometrial estrogen and progesterone receptor induction in women

1991 • 42 citations

Haemostatic changes and thromboembolic risk during tamoxifen therapy in normal women

1992 • 41 citations

Neuroendocrinology of Aging in Humans: Attenuated Sensitivity to Sex Steroid Feedback in Elderly Postmenopausal Women

1994 • 40 citations

ENDOMETRIAL HISTOLOGY AND CONCEPTION RATES AFTER CLOMIPHENE CITRATE

1972 • 39 citations

Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats

1995 • 37 citations

A prospective, randomised, cross‐over study comparing the effects of clomiphene citrate and cyclofenil on endometrial morphology in the luteal phase of normal, fertile women

1992 • 37 citations

Combined endocrine effects of LHRH agonist (Zoladex®) and tamoxifen (Nolvadex®) therapy in premenopausal women with breast cancer

1989 • 36 citations

Clomiphene citrate reduces serum insulin-like growth factor I and increases sex hormone-binding globulin levels in women with polycystic ovary syndrome

1995 • 33 citations

Treatment with Tamoxifen and Progestins for Metastatic Breast Cancer in Postmenopausal Women: A Quantitative Review of Published Randomized Clinical Trials

1993 • 31 citations

The effects of clomiphene citrate upon ovulation and endocrinology when administered to patients with unexplained infertility

1991 • 31 citations

Clomiphene Citrate and Pregnancy Outcome

1994 • 31 citations

Postmenopausal Tamoxifen Treatment and Endometrial Pathology

1994 • 31 citations

Tamoxifen and endometriosis. Case report

1990 • 28 citations

Evaluation of the reproductive performance of women with elevated day 10 progesterone levels during ovarian reserve screening

1995 • 27 citations

The effects of clomiphene citrate on the histology of human endometrium in regularly cycling women undergoing in vitro fertilization

1988 • 27 citations

Introduction to toremifene

1990 • 26 citations

Physiology: Effects of the pure anti-oestrogen ICI 182780 on oestrogen receptors, progesterone receptors and Ki67 antigen in human endometrium in vivo

1995 • 25 citations

Intestinal and pelvic endometriosis presenting as a tumor and associated with tamoxifen therapy: Report of a case

1994 • 24 citations

Luteal insufficiency: Correlation between endometrial dating and integrated progesterone output in clomiphene citrate-induced cycles

1990 • 23 citations

Exogenous estrogen therapy for treatment of clomiphene citrate-induced cervical mucus abnormalities: is it effective?

1990 • 22 citations

Efficacy of clomiphene citrate in the treatment of luteal phase deficiency: quantity versus quality of preovulatory follicles

1990 • 22 citations

Exogenous estrogen therapy for treatment of clomiphene citrate‐induced cervical mucus abnormalities: Is it effective?

1991 • 22 citations

Embryo toxicity of clomiphene citrate on mouse embryos fertilized in vitro and in vivo

1985 • 21 citations

Effectiveness of Antiestrogens in Infertile Men

1993 • 21 citations

Antiestrogen action and growth factor regulation

1994 • 20 citations

Antiestrogens as Treatment of Female and Male Infertilities

1987 • 20 citations

Chemohormonal therapy and endocrine function in breast cancer patients

1985 • 19 citations

Diagnosis and management of out-of-phase endometrial biopsies among patients receiving clomiphene citrate for ovulation induction

1989 • 19 citations

Combination goserelin and tamoxifen therapy in premenopausal advanced breast cancer: a multicentre study by the ITMO group

1995 • 18 citations

Long-term adjuvant tamoxifen therapy for breast cancer: The prelude to prevention

1990 • 16 citations

Efficacy of clomiphene citrate in the treatment of luteal phase deficiency: Quantity versus quality of preovulatory follicles

1991 • 15 citations

Enhanced Preovulatory Progesterone Levels in Clomiphene Citrate-Induced Cycles

1989 • 14 citations

Intestinal and pelvic endometriosis presenting as a tumor and associated with tamoxifen therapy: Report of a case

1993 • 13 citations

Gonadotropin pulsatility in a stimulated cycle: clomiphene citrate increases pulse amplitudes of both luteinizing hormone and follicle-stimulating hormone

1991 • 11 citations

Effects of clomiphene citrate on episodic luteinizing hormone secretion throughout the menstrual cycle

1989 • 10 citations

The luteinizing hormone surge: timing and characteristics in the plasma and urine after clomiphene citrate treatment

1989 • 9 citations

Addin of Exogenous Estrogens To Improve Cervical Mucus Following Clomiphene Citrate Medication: Patient Selection

1990 • 4 citations

Pulsatile Luteinizing Hormone Secretion in Women with Polycystic Ovary Syndrome under Clomiphene Citrate. Differences between Responders and Nonresponders^{a , b})

2009 • 2 citations