Action of ?pure? antiestrogens in inhibiting estrogen receptor action

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

A potent specific pure antiestrogen with clinical potential.

1991 • 1,111 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

1992 • 468 citations

Immunochemical studies of estrogen receptors

1984 • 439 citations

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

1990 • 400 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

Nucleocytoplasmic shuttling of the progesterone receptor.

1991 • 296 citations

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen.

1993 • 215 citations

The Mechanism of ICI 164,384 Antiestrogenieity Involves Rapid Loss of Estrogen Receptor in Uterine Tissue

1991 • 201 citations

Novel steroidal pure antiestrogens

1989 • 200 citations

Steroid and related receptors

1993 • 199 citations

Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.

1991 • 195 citations

P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody.

1992 • 181 citations

Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity.

1989 • 180 citations

Biology and mode of action of pure antioestrogens.

1988 • 149 citations

Biology and mode of action of pure antioestrogens

1988 • 136 citations

Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination.

1992 • 126 citations

Identification of Cysteine 530 as the Covalent Attachment Site of an Affinity-labeling Estrogen (Ketononestrol Aziridine) and Antiestrogen (Tamoxifen Aziridine) in the Human Estrogen Receptor

1989 • 121 citations

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

1991 • 99 citations

Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster.

1992 • 89 citations

Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element.

1991 • 84 citations

Nuclear hormone receptors — Molecular mechanisms, cellular functions, clinical abnormalities

1992 • 83 citations

The effect of anti-oestrogens on cell growth and progesterone receptor concentration in human endometrial cancer cells (Ishikawa)

1991 • 67 citations

Effect of antioestrogens on the DNA binding activity of oestrogen receptorsin vitro

1992 • 44 citations

Antiestrogen action in mammary cancer and in fetal cells

1990 • 19 citations