Clomiphene citrate: mechanism(s) and site(s) of action—a hypothesis revisited

The Neuroendocrine Control of the Menstrual Cycle

1980 • 1,288 citations

Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones

1983 • 526 citations

Pituitary Stalk Portal Blood Collection in Rhesus Monkeys: Evidence for Pulsatile Release of Gonadotropin-Releasing Hormone (GnRH)

1976 • 482 citations

Pregnancies in Humans by Fertilization in Vitro and Embryo Transfer in the Controlled Ovulatory Cycle

1981 • 379 citations

Pituitary and Gonadal Hormones in Women during Spontaneous and Induced Ovulatory Cycles

1970 • 376 citations

Estradiol-Concentrating Neurons: Topography in the Hypothalamus by Dry-Mount Autoradiography

1968 • 298 citations

The agonistic-antagonistic properties of clomiphene: A review

1981 • 222 citations

Estradiol Receptor Content in Rat Granulosa Cells During Follicular Development: Modification by Estradiol and Gonadotropins

1975 • 213 citations

Autoradiographic localization of hormone‐concentrating cells in the brain of the female rhesus monkey

1976 • 169 citations

Estrogens augment the stimulation of ovarian aromatase activity by follicle-stimulating hormone in cultured rat granulosa cells.

1982 • 162 citations

Luteal phase dysfunction infertility: a sequel to aberrant folliculogenesis

1981 • 158 citations

New Synthetic Agent for the Induction of Ovulation: Preliminary Trials in Women

1971 • 133 citations

EFFECT OF SOME TRIPHENYLETHYLENES ON OESTRADIOL BINDING IN VITRO TO MACROMOLECULES FROM UTERUS AND ANTERIOR PITUITARY

1972 • 115 citations

THE INDUCTION OF OVULATION BY TAMOXIFEN

1973 • 104 citations

EFFECTS OF CLOMIPHENE ON THE PHYSIOLOGY OF REPRODUCTION IN THE RAT

1964 • 94 citations

Effect of Clomiphene on the Uptake of Estradiol by the Anterior Hypothalamus and Hypophysis

1968 • 91 citations

DIRECT ENHANCEMENT OF GONADOTROPIN-STIMULATED OVARIAN ESTROGEN BIOSYNTHESIS BY ESTROGEN AND CLOMIPHENE CITRATE

1982 • 89 citations

New Evidence for an Anti-estrogenic Action of Clomiphene Citrate in Women

1971 • 80 citations

The in vivo and in vitro effects of clomiphene citrate on ovulation, fertilization, and development of cultured mouse oocytes

1983 • 72 citations

Action of MER-25 and of Clomiphene on the Human Ovary

1963 • 66 citations

Estradiol “Receptors” in Hypothalamus and Anterior Pituitary Gland: Inhibition of Estradiol Binding by SH-Group Blocking Agents and Clomiphene Citrate

1970 • 65 citations

Induction of ovulation with clomiphene

1965 • 60 citations

Sensitisation of pituitary cells to luteinising hormone releasing hormone by clomiphene citrate in vitro

1978 • 58 citations

Stereospecificity of closely related compounds which block postganglionic acetylcholine receptors in the guinea-pig ileum

1973 • 57 citations

Effects of clomiphene citrate**The authors wish to acknowledge their indebtedness to Dr. Mark T. Hoekenga of The Wm. S. Merrell Co. for supplying the drug used in this investigation.on anovulatory ovarian function

1964 • 52 citations

Antiestrogenic action of high-dose clomiphene in primates: pituitary augmentation but with ovarian attenuation

1982 • 50 citations

Mode and site of action of clomiphene

1967 • 50 citations

Œstrous Reactions, including Mating, Produced by Triphenyl Ethylene

1937 • 49 citations

Comparison between tamoxifen and clomiphene for induction of ovulation.

1982 • 49 citations

Evidence for estradiol binding sites in the hypothalamus—Effect of drugs

1967 • 48 citations

Effect of Clomiphene Citrate on Preovulatory Rat Follicles in Culture

1982 • 45 citations

High-performance liquid chromatographic determination of clomiphene using post-column on-line photolysis and fluorescence detection

1981 • 45 citations

DIFFERENTIAL DEPLETION OF CYTOPLASMIC HIGH AFFINITY OESTROGEN RECEPTORS AFTER THE in vivo ADMINISTRATION OF THE ANTIOESTROGENS, CLOMIPHENE, MER‐25 AND TAMOXIFEN

1978 • 42 citations

Disparate effect of clomiphene and tamoxifen on pituitary gonadotropin release in vitro

1981 • 41 citations

Antiestrogenic Effect of Clomiphene in the Human Being

1968 • 40 citations

Induction of Ovulation with Human Gonadotropins and with Clomiphene

1965 • 40 citations

Substituted Aminoalkoxytriarylhaloethylenes

1967 • 39 citations

Stereochemistry of geometric isomers of clomiphene: A Correction of the Literature and a Reexamination of Structure‐Activity Relationships

1976 • 38 citations

Clomiphene and Tamoxifen Inhibit Progesterone Synthesis in Granulosa Cells: Comparison with Estradiol

1984 • 38 citations

Cooperativity pattern in the interaction of the antiestrogen drug clomiphene with the Muscarinic receptors.

1982 • 37 citations

Alteration of LH and FSH release in rats treated with clomiphene or its isomers

1970 • 36 citations

Cyclic Clomiphene Citrate Treatment Lowers Cytosol Estrogen and Progestin Receptor Concentrations in the Endometrium of Postmenopausal Women on Estrogen Replacement Therapy*

1981 • 35 citations

Reversal of benign and malignant endometrial changes with Clomiphene

1964 • 34 citations

Estrogenic and Antiestrogenic Effects of Enclomiphene and Zuclomiphene on Gonadotropin Secretion by Ovine Pituitary Cells in Culture*

1983 • 32 citations

Distribution of³H-estradiol in Clomiphene-Treated and Neonatally Androgenized Rats1

1971 • 32 citations

Clomiphene citrate induces luteinizing hormone release through hypothalamic luteinizing hormone-releasing hormone in vitro

1983 • 31 citations

Duration of Action of Natural and Synthetic Œstrogens

1938 • 30 citations

Inhibition of Ovarian Follicle Growth by a Chemical Antiestrogen

1982 • 29 citations

Endocrine profiles in tamoxifen-induced ovulatory cycles

1983 • 29 citations

The effect of clomid on estrogen secretion and metabolism

1966 • 27 citations

MODE OF ACTION OF CLOMIPHENE

1969 • 26 citations

EFFECT OF CLOMIPHENE ON AROMATIZATION OF STEROIDS BY THE HUMAN PLACENTA IN VITRO

1963 • 25 citations

Effects of Clomiphene Citrate on Pituitary FSH, FSH-RF, and Release of LH in Immature and Mature Rats

1970 • 25 citations

Chemical Induction of Ovulation

1962 • 24 citations

ALTERATIONS INDUCED BY CLOMIPHENE IN THE CONCENTRATIONS OF OESTROGEN RECEPTORS IN THE UTERUS, PITUITARY GLAND AND HYPOTHALAMUS OF FEMALE RATS

1980 • 23 citations

Synthetic Estrogens. Halotriphenylethylene Derivatives

1953 • 22 citations

Postmenopausal hormone replacement therapy with estrogen periodically supplemented with antiestrogen

1981 • 21 citations

Effect of Clomiphene Upon Plasma FSH-Activity and Hypothalamic FSH-RF Content in Ovariectomized Estrogen-Progesterone Blocked Rats

1969 • 21 citations

Effect of estradiol benzoate and clomiphene on tyrosine hydroxylase activity and on luteinizing hormone and prolactin levels in ovariectomized rats

1981 • 20 citations

Effects of Clomiphene on Luteal Function in the Nonpregnant Cynomoigus Macaque

1983 • 19 citations

Studies on the Anti-Oestrogenic and Oestrogen-Like Action of Clomiphene Citrate in Women

1972 • 18 citations

Clomiphene citrate induction of ovulation

1983 • 17 citations

Suppression of the Decidual Response with Estrogen Antagonists

1965 • 17 citations

Effect of Clomiphene Citrate on Plasma Levels of Immunoreactive Luteinizing Hormone-Releasing Hormone, Gonadotropin, and Testosterone in Normal Subjects and in Patients With Idiopathic Oligospermia

1978 • 17 citations

An effect in vivo of clomiphene on the rate of conversion of androstenedione-C14 to estrone-C14 and estradiol-C14 by the canine ovary

1968 • 17 citations

OVULATION-INDUCING ACTION OF CLOMIPHENE CITRATE IN THE RAT

1969 • 16 citations

Effects of clomiphene citrate on endometrial hyperplasia in the premenopausal female

1966 • 16 citations

MECHANISM OF THE STIMULATORY EFFECT OF CLOMID® ON AROMATIZATION OF STEROIDS BY HUMAN PLACENTA IN VITRO

1966 • 15 citations

STUDIES ON THE ANTI-OVULATORY AND OVULATORY ACTION OF CLOMIPHENE CITRATE IN THE RAT

1971 • 13 citations

Biologic effects of clomiphene citrate in the castrated rhesus monkey

1965 • 13 citations

Action of tamoxifen on folliculogenesis in the menstrual cycle of infertile patients

1983 • 13 citations

CHANGES IN BRAIN, PITUITARY AND UTERINE CYTOPLASMIC OESTROGEN RECEPTORS INDUCED BY OESTRADIOL-17β IN THE OVARIECTOMIZED RAT

1976 • 13 citations

The effect of clomiphene and cyclofenil upon pituitary LH and hypothalamic LH-Releasing-Factor content in the female rat

1970 • 13 citations

Contrasting Actions of Cis- and Trans-Clomiphene on the Release of FSH and FSH-RF in the Female Rat

1970 • 12 citations

Inhibition of the Ovarian Augmentation Reaction by a Chemical Antiestrogen

1975 • 12 citations

Changes in Plasma Luteinizing Hormone-Releasing Hormone During Clomiphene-Induced Ovulatory Cycles

1980 • 12 citations

Effect of Clomiphene Citrate on Basal and LRH-Induced Gonadotropin Secretion in Postmenopausal Women

1976 • 10 citations

Induction of Oestrous Changes in the Monkey and Bitch by Triphenyl Ethylene.

1938 • 9 citations

Steroid sulphate secretion by the human ovary In vitro: Influence of gonadotrophins, cyclofenil and clomiphene

1980 • 8 citations

GONADOTROPHIN RELEASE IN OVARIECTOMIZED PATIENTS

1977 • 5 citations

Effects of Clomid and Sexovid on FSH and LH Secretion in Mature Female Rats

1972 • 5 citations

The effect of clomiphene citrate on LH release by dispersed rat anterior pituitary cells

1983 • 4 citations

Vitellogenesis in bidderian oocytes after diethylstilbestrol dipropionate treatment onBufo bufo adult males

1970 • 2 citations

Untersuchungen �ber den Wirkungsmechanismus von Clomifen: Hemmung der Oestradiolaufnahme in Hypothalamus und Hypophyse der Ratte

1973 • 1 citations

[Clinical results acquired in the treatment of the anovulatory state with a new drug: chlorotrianisene, a non-steroid synthetic estrogen].

1962 • 1 citations