Long-term adjuvant tamoxifen therapy for breast cancer: The prelude to prevention

A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

1989 • 1,471 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

ADJUVANT TAMOXIFEN IN EARLY BREAST CANCER: OCCURRENCE OF NEW PRIMARY CANCERS

1989 • 932 citations

Effects of Adjuvant Tamoxifen and of Cytotoxic Therapy on Mortality in Early Breast Cancer

1988 • 921 citations

The pharmacology and clinical uses of tamoxifen

1984 • 873 citations

A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474

1971 • 692 citations

The Risk of Breast Cancer after Estrogen and Estrogen–Progestin Replacement

1989 • 624 citations

Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins.

1985 • 495 citations

A NEW DERIVATIVE OF TRIPHENYLETHYLENE: EFFECT ON IMPLANTATION AND MODE OF ACTION IN RATS

1967 • 456 citations

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse.

1988 • 420 citations

Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration.

1988 • 417 citations

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

1985 • 396 citations

Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata

1976 • 377 citations

Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels

1973 • 373 citations

Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model.

1987 • 355 citations

Effects of anti-estrogens on bone in castrated and intact female rats

1987 • 329 citations

Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes

1966 • 315 citations

STEROIDAL PURE ANTIOESTROGENS

1987 • 313 citations

Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase

1984 • 296 citations

CONTROLLED TRIAL OF TAMOXIFEN AS SINGLE ADJUVANT AGENT IN MANAGEMENT OF EARLY BREAST CANCER

1985 • 291 citations

TAMOXIFEN AND THE UTERUS AND ENDOMETRIUM

1989 • 252 citations

Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens.

1989 • 249 citations

Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells.

1988 • 247 citations

Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer

1988 • 247 citations

Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats

1987 • 243 citations

Tamoxifen Inhibits Osteoclast-Mediated Resorption of Trabecular Bone in Ovarian Hormone-Deficient Rats*

1988 • 224 citations

Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial.

1986 • 215 citations

Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

1980 • 212 citations

STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTI-OESTROGENS WITH REGARD TO INTERACTION WITH 17β-OESTRADIOL IN THE MOUSE UTERUS AND VAGINA

1971 • 211 citations

Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats.

1980 • 206 citations

Effects of Tamoxifen on Spinal Bone Density in Women With Breast Cancer

1989 • 197 citations

Hormonal Pathogenesis of Adenocarcinoma of the Breast

1936 • 195 citations

Tamoxifen retinopathy

2014 • 195 citations

Human breast cancer in the athymic nude mouse: Cystostatic effects of long-term antiestrogen therapy

1987 • 186 citations

The Metabolism of Tamoxifen (I.C.I. 46,474) Part I : In Laboratory Animals

1973 • 181 citations

Estrogen responsive proliferation of clonal human breast carcinoma cells in athymic mice

1980 • 178 citations

Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice.

1984 • 176 citations

Randomized trial of bilateral oophorectomy versus tamoxifen in premenopausal women with metastatic breast cancer.

1986 • 175 citations

Tamoxifen therapy in primary breast cancer: biology, efficacy, and side effects.

1989 • 171 citations

A randomized comparison of tamoxifen with surgical oophorectomy in premenopausal patients with advanced breast cancer.

1986 • 160 citations

Bone mineral density in women with breast cancer treated with adjuvant tamoxifen for at least two years

1988 • 157 citations

EFFECT OF THE ANTI-OESTROGEN TAMOXIFEN ON PLASMA LEVELS OF LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE, PROLACTIN, OESTRADIOL AND PROGESTERONE IN NORMAL PRE-MENOPAUSAL WOMEN

1976 • 154 citations

Endocrine effects of adjuvant chemotherapy and long-term tamoxifen administration on node-positive patients with breast cancer.

1987 • 154 citations

Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: A model to study the tumoristatic action of tamoxifen

1988 • 147 citations

ADJUVANT TAMOXIFEN IN THE MANAGEMENT OF OPERABLE BREAST CANCER: THE SCOTTISH TRIAL

1987 • 145 citations

Endocrine Consequences of Continuous Antiestrogen Therapy with Tamoxifen in Premenopausal Women

1979 • 144 citations

Pharmacology of tamoxifen in laboratory animals.

1980 • 142 citations

Triphenylethylenes: A New Class of Protein Kinase C Inhibitors

1986 • 138 citations

Estrogen-Like Action of Tamoxifen on Vaginal Epithelium in Breast Cancer Patients

1981 • 138 citations

TAMOXIFEN AS AN ANTI-TUMOUR AGENT: EFFECT ON OESTROGEN BINDING

1976 • 134 citations

Serum lipoproteins and proteins after breast cancer surgery and effects of tamoxifen

1984 • 133 citations

Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance

1982 • 133 citations

Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice.

1990 • 127 citations

Adjuvant tamoxifen in primary breast cancer: Influence on plasma lipids and antithrombin III levels

1988 • 125 citations

Tamoxifen retinopathy.

1978 • 125 citations

Long-term adjuvant therapy with tamoxifen: effects on sex hormone binding globulin and antithrombin III.

1987 • 124 citations

Endocrine status of premenopausal node-positive breast cancer patients following adjuvant chemotherapy and long-term tamoxifen.

1988 • 120 citations

Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer

1990 • 119 citations

Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro.

1989 • 117 citations

Role and mechanism of action of tamoxifen in premenopausal women with metastatic breast carcinoma.

1986 • 113 citations

Effects of adjuvant chemohormonal therapy on the ovarian and adrenal function of breast cancer patients.

1980 • 109 citations

Venous thrombosis as a side effect of tamoxifen treatment.

1984 • 107 citations

THE INDUCTION OF OVULATION BY TAMOXIFEN

1973 • 104 citations

Antihormone treatment of stage IV breast cancer

1979 • 100 citations

Long-term tamoxifen adjuvant therapy in node-positive breast cancer: A metabolic and pilot clinical study

1984 • 99 citations

Determination and pharmacology of a new hydroxylated metabolite of tamoxifen observed in patient sera during therapy for advanced breast cancer.

1983 • 96 citations

A comparison of two doses of tamoxifen (Nolvadex) in postmenopausal women with advanced breast cancer: 10 mg bd versus 20 mg bd

1984 • 96 citations

Antiestrogenic action of toremifene on hormone-dependent, -independent, and heterogeneous breast tumor growth in the athymic mouse.

1989 • 95 citations

Tamoxifen in the Treatment of Breast Cancer

1988 • 94 citations

Antiestrogen-induced remissions in premenopausal women with stage IV breast cancer: effects on ovarian function.

1980 • 92 citations

The effectiveness of long term tamoxifen treatment in a laboratory model for adjuvant hormone therapy of breast cancer.

1979 • 89 citations

Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: Limitations to the interpretation of experiments characterizing the activity of individual isomers

1985 • 89 citations

Identification and biological activity of tamoxifen metabolites in human serum

1983 • 85 citations

Breast cancer management : early and late

1977 • 85 citations

Tamoxifen treatment of metastatic breast cancer and antithrombin III levels

1984 • 80 citations

Adjuvant Tamoxifen Treatment of Elderly Women with Stage II Breast Cancer

1985 • 80 citations

Chemosuppression of Breast Cancer with Tamoxifen: Laboratory Evidence and Future Clinical Investigations

1988 • 78 citations

Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12-dimethylbenzanthracene-induced rat mammary carcinoma model.

1987 • 74 citations

Adjuvant trial of 12 cycles of CMFPT followed by observation or continuous tamoxifen versus four cycles of CMFPT in postmenopausal women with breast cancer: an Eastern Cooperative Oncology Group phase III study.

1990 • 73 citations

TAMOXIFEN AS AN ANTI-TUMOUR AGENT: ROLE OF OESTRADIOL AND PROLACTIN

1976 • 70 citations

Mechanisms of growth inhibition by nonsteroidal antioestrogens in human breast cancer cells

1987 • 69 citations

Contrasting ability of antiestrogens to inhibit MCF-7 growth stimulated by estradiol or epidermal growth factor

1989 • 68 citations

Oestrogen-like effects of tamoxifen on the concentration of proteins in plasma

1981 • 66 citations

Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth

1987 • 60 citations

Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM)

1987 • 58 citations

Serum concentrations of tamoxifen and major metabolite during long-term nolvadex therapy, correlated with clinical response.

1980 • 53 citations

Therapeutic effect of tamoxifen versus tamoxifen combined with medroxyprogesterone acetate in advanced breast cancer in postmenopausal women.

1979 • 52 citations

Photoaffinity labeling of the progesterone receptor from human endometrial carcinoma.

1985 • 52 citations

Anti-oestrogenic and anti-tumour properties of prolonged tamoxifen therapy in C3H/OUJ mice

1990 • 49 citations

Treatment of advanced endometrial adenocarcinoma with tamoxifen.

1980 • 48 citations

PROLONGED ANTIOESTROGENIC ACTIVITY OF ICI 46,474 IN THE OVARIECTOMIZED MOUSE

1975 • 48 citations

Antitumor actions of toremifene in the 7,12-dimethylbenzanthracene (DMBA)-induced rat mammary tumor model

1988 • 48 citations

Tamoxifen and Thromboembolism

1980 • 47 citations

Mammary Tumors in Mice in Relation to Nursing

1937 • 47 citations

A COMPARISON OF THE EFFECTS OF CLOMIPHENE AND TAMOXIFEN TREATMENT ON THE CONCENTRATIONS OF OESTRADIOL AND PROGESTERONE IN THE PERIPHERAL PLASMA OF INFERTILE WOMEN

1978 • 47 citations

A controlled study of the ocular effects of tamoxifen in conventional dosage in the treatment of breast carcinoma

1989 • 46 citations

Adjuvant tamoxifen in postmenopausal breast cancer: Preliminary results of a randomized trial

1986 • 46 citations

Non-steroidal antioestrogens : molecular pharmacology and antitumour activity

1981 • 46 citations

The paracrine stimulation of MCF-7 cells by MDA-MB-231 cells: Possible role in antiestrogen failure

1989 • 40 citations

Combined endocrine effects of LHRH agonist (Zoladex®) and tamoxifen (Nolvadex®) therapy in premenopausal women with breast cancer

1989 • 36 citations

Immune-deficient animals to study “hormone-dependent” breast and endometrial cancer

1989 • 32 citations

Use of the DMBA-induced rat mammary carcinoma system for the evaluation of tamoxifen treatment as a potential adjuvant therapy.

1978 • 32 citations

Endocrine profiles in tamoxifen-induced ovulatory cycles

1983 • 29 citations

Adjuvant tamoxifen therapy for early breast cancer: An experimental study with reference to oestrogen and progesterone receptors

1982 • 24 citations

Chemohormonal therapy and endocrine function in breast cancer patients

1985 • 19 citations

A NEW SYNTHETIC AGENT FOR THE INDUCTION OF OVULATION ^*

1974 • 19 citations

Use of LH-RH agonists in the treatment of breast disease

1989 • 14 citations

Antitumor effect of the antiestrogen, tamoxifen, ona pregnancy-dependent mouse mammary tumor (TPDMT-4).

1981 • 12 citations

Tamoxifen and thromboembolism

1980 • 12 citations

Mammary Tumour Development in BR6 Mice: Hormonal Stimulation

1970 • 11 citations

Long-Term Adjuvant Therapy with Tamoxifen in Breast Cancer: How Long Is Long?

1987 • 10 citations