Synergistic induction of interleukin-6 production and gene expression in human thymic epithelial cells by LPS and cytokines

Van Damme A.

1986 • 3,477 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Peptide growth factors are multifunctional

1988 • 835 citations

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

1988 • 537 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Soluble cytokine receptors are present in normal human urine.

1989 • 441 citations

Involvement of IL-6 in mesangial proliferative glomerulonephritis.

1989 • 415 citations

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.

1988 • 382 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

1988 • 365 citations

Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes.

1988 • 278 citations

IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA.

1990 • 242 citations

Molecular cloning and expression of hybridoma growth factor in Escherichia coli.

1987 • 238 citations

Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes.

1990 • 237 citations

Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages

1988 • 234 citations

Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.

1987 • 213 citations

Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts.

1987 • 199 citations

Synergism of BSF-2/interleukin 6 and interleukin 3 on development of multipotential hemopoietic progenitors in serum-free culture.

1988 • 165 citations

Synergistic activation of human monocytes by granulocyte-macrophage colony-stimulating factor and IFN-gamma. Increased TNF-alpha but not IL-1 activity.

1988 • 139 citations

Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants.

1990 • 138 citations

Human thymic epithelial cells produce interleukin 1.

1987 • 136 citations

Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1 alpha and interleukin-6.

1989 • 132 citations

Evidence for IL-6 production by and effects on the pancreatic beta-cell.

1989 • 121 citations

The Role of the Thymus in Myasthenia Gravis: Immunohistological and Immunological Studies in 115 Cases^a

1987 • 119 citations

Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor.

1990 • 116 citations

Interferon-gamma modulates HLA class II antigen expression on cultured human thymic epithelial cells.

1985 • 110 citations

IL-6 and IL-1 synergize to stimulate IL-2 production and proliferation of peripheral T cells.

1989 • 102 citations

Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors.

1988 • 97 citations

Distinct roles of IL-1 and IL-6 in human T cell activation.

1989 • 95 citations

Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells.

1990 • 92 citations

Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes.

1990 • 84 citations

Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.

1987 • 84 citations

IL-6 is an intermediate in IL-1-induced thymocyte proliferation.

1989 • 81 citations

Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation.

1987 • 70 citations

Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells.

1990 • 63 citations

In situ production of interleukins in hyperplastic thymus from myasthenia gravis patients

1991 • 53 citations

Cooperation between an anti-T cell (anti-CD28) monoclonal antibody and monocyte-produced IL-6 in the induction of T cell responsiveness to IL-2.

1988 • 50 citations

Regulation of macrophage activation by IL-3. II. IL-3 and lipopolysaccharide act synergistically in the regulation of IL-1 expression.

1990 • 47 citations

Lymphokine-mediated induction of antigen-presenting ability in thymic stromal cells.

1987 • 44 citations

Effects of cytokines on human thymic epithelial cells in culture

1990 • 36 citations

Feedback regulation of the secretion of a thymic hormone (thymulin) by human thymic epithelial cells in culture.

1986 • 34 citations

Interleukin-6 production by tumor necrosis factor and lipopolysaccharide-stimulated rat renal cells

1990 • 26 citations