Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation

Reshaping human antibodies for therapy

1988 • 1,555 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

RELEASE OF TUMOR NECROSIS FACTOR, INTERLEUKIN-2, AND GAMMA-INTERFERON IN SERUM AFTER INJECTION OF OKT3 MONOCLONAL ANTIBODY IN KIDNEY TRANSPLANT RECIPIENTS

1989 • 361 citations

T cell suppression in transplantation tolerance through linked recognition.

1996 • 246 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

The generation of a humanized, non‐mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

1993 • 217 citations

Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes

1979 • 212 citations

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

1989 • 198 citations

Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.

1999 • 183 citations

Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis.

1988 • 141 citations

PHASE I STUDY OF AN ENGINEERED AGLYCOSYLATED HUMANIZED CD3 ANTIBODY IN RENAL TRANSPLANT REJECTION1

1999 • 140 citations

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.

1993 • 127 citations

In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: differential modulation by cyclosporin A.

1993 • 124 citations

ANTI-CD3 F(abʼ)2 FRAGMENTS ARE IMMUNOSUPPRESSIVE IN VIVO WITHOUT EVOKING EITHER THE STRONG HUMORAL RESPONSE OR MORBIDITY ASSOCIATED WITH WHOLE mAb

1990 • 124 citations

Insulin-dependent diabetes mellitus as an autoimmune disease

1994 • 103 citations

Spontaneous Diabetes in Rats: Destruction of Islets Is Prevented by Immunological Tolerance

1981 • 101 citations

Induction of T cell proliferation with anti‐CD3 switch‐variant monoclonal antibodies: effects of heavy chain isotype in monocyte‐dependent systems

1987 • 90 citations

Use of homozygous allogeneic bone marrow for induction of tolerance with antilymphocyte serum: dose and timing.

1971 • 86 citations

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

1997 • 85 citations

In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

1985 • 79 citations

Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats

2000 • 78 citations

Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway.

1996 • 72 citations

Induction of T helper cell hyporesponsiveness in an experimental model of autoimmunity by using nonmitogenic anti-CD3 monoclonal antibody.

1994 • 72 citations

Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAb

1994 • 71 citations

Curing BB rats of freshly manifested diabetes by short‐term treatment with a combination of a monoclonal anti‐interleukin 2 receptor antibody and a subtherapeutic dose of cyclosporin A

1987 • 57 citations

Type-I Diabetes: A Chronic Autoimmune Disease Of Human, Mouse, And Rat

1990 • 47 citations

Prevention of autoimmune recurrence and rejection by adenovirus-mediated CTLA4Ig gene transfer to the pancreatic graft in BB rat.

1999 • 47 citations

Long-term function (6 years) of islet allografts in type 1 diabetes

1997 • 39 citations

Anti-CD3 antibodies induce T cells from unprimed animals to secrete IL-4 both in vitro and in vivo.

1990 • 39 citations

Use of anti-CD3 epsilon F(ab')2 fragments in vivo to modulate graft-versus-host disease without loss of graft-versus-leukemia reactivity after MHC-matched bone marrow transplantation.

1995 • 38 citations

Differential T cell hyporesponsiveness induced by in vivo administration of intact or F(ab')2 fragments of anti-CD3 monoclonal antibody. F(ab')2 fragments induce a selective T helper dysfunction.

1991 • 36 citations

Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody

1992 • 36 citations

Transplantation of pancreas and islets of Langerhans: a review of progress

1996 • 18 citations

Pancreas Transplantation

1999 • 10 citations

Islet transplantation in spontaneously diabetic BB/Wor rats

1989 • 4 citations

Recurrence of Autoimmune Diabetes Mellitus in Recipients of Cadaveric Pancreatic Grafts

1996 • 4 citations

Islet Cell Transplantation: Beyond the Paradigms

1996 • 3 citations

CONTRASTING IN VIVO EFFECTS ON T HELPER CELL FUNCTIONS INDUCED BY MITOGENIC (INTACT) VERSUS NONMITOGENIC (F(abʼ2) ANTI-CD3 MONOCLONAL ANTIBODY

1995 • 1 citations