Immune responses to dietary antigens: oral tolerance

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

The anatomical basis of intestinal immunity

1997 • 493 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Systemic tolerance and secretory immunity after oral immunization.

1980 • 432 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Cholera toxin and cholera B subunit as oral—mucosal adjuvant and antigen vector systems

1993 • 324 citations

Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.

1994 • 317 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

Is CTLA-4 a master switch for peripheral T cell tolerance?

1997 • 284 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Food Allergy

2013 • 254 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.

1997 • 227 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

Immune Responses to Fed Protein Antigens in Mice. 3. Systemic Tolerance or Priming Is Related to Age at Which Antigen Is First Encountered

1984 • 221 citations

Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.

1997 • 220 citations

Simultaneous induction of antigen-specific IgA helper T cells and IgG suppressor T cells in the murine Peyer's patch after protein feeding.

1981 • 195 citations

Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

1997 • 180 citations

Production of immunity and unresponsiveness in the mouse by feeding contact sensitizing agents and the role of suppressor cells in the Peyer's patches, mesenteric lymph nodes and other lymphoid tissues

1977 • 173 citations

T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction.

1995 • 171 citations

Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.

1995 • 167 citations

MHC class II expression by the gut epithelium

1988 • 164 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Treatment of Uveitis by Oral Administration of Retinal Antigens: Results of a Phase I/II Randomized Masked Trial

1997 • 155 citations

CD4⁺ but not CD8⁺T cells are required for the induction of oral tolerance

1995 • 153 citations

Immunological responses to fed protein antigens in mice. I. Reversal of oral tolerance to ovalbumin by cyclophosphamide.

1982 • 136 citations

Oral Tolerance in Experimental Autoimmune Encephalomyelitis

1996 • 136 citations

Dendritic cells and tolerance induction

1996 • 128 citations

Anti-γδ T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice

1995 • 118 citations

Direct measurement of anergy of antigen-specific T cells following oral tolerance induction.

1996 • 118 citations

Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals

1994 • 114 citations

In vivo tolerization of Th1 lymphocytes following a single feeding with ovalbumin: Anergy in the absence of suppression

1994 • 113 citations

Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.

1994 • 107 citations

Immunological responses to fed protein antigens in mice. II. Oral tolerance for CMI is due to activation of cyclophosphamide-sensitive cells by gut-processed antigen.

1983 • 102 citations

Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells.

1996 • 101 citations

Inductive Events in Oral Tolerance in the TCR Transgenic Adoptive Transfer Model

1997 • 98 citations

Could specific oral tolerance be a therapy for autoimmune disease?

1990 • 95 citations

The generation of a ‘tolerogen’ after the ingestion of ovalbumin is time-dependent and unrelated to serum levels of immunoreactive antigen

1990 • 94 citations

Essentials of Mucosal Immunology

1996 • 94 citations

Orally Induced Tolerance

1981 • 91 citations

Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.

1990 • 90 citations

Induction of Th1 and Th2 CD4⁺ T cell responses by oral or parenteral immunization with ISCOMS

1995 • 88 citations

Activation of CD4⁺ T cells by delivery of the B7 costimulatory signal on bystander antigen‐presenting cells (trans‐costimulation)

1994 • 86 citations

Oral Induction of Tolerance to Nickel Sensitization in Mice

1993 • 81 citations

Peripheral tolerance of T_h2 lymphocytes induced by continuous feeding of ovalbumin

1996 • 80 citations

Regulation of transforming growth factor‐β production by interleukin‐12

1997 • 77 citations

Effect of in Vivo Depletion of CD4+ and CD8+ Cells on the Induction and Maintenance of Oral Tolerance

1995 • 74 citations

Persistence of oral tolerance in mice fed ovalbumin is different for humoral and cell-mediated immune responses.

1987 • 66 citations

B cells are not essential for peripheral T-cell tolerance.

1996 • 65 citations

The kinetics of oral hyposensitization to a protein antigen are determined by immune status and the timing, dose and frequency of antigen administration.

1989 • 64 citations

Remarks on a Cutaneous Affection, prodused by cretain Poisonous Vagetables

1829 • 63 citations

Neonatal Oral Tolerancea

1996 • 59 citations

Modulation of intestinal and systemic immune responses to a fed protein antigen, in mice.

1986 • 57 citations

Immunosuppression caused by antigen feeding II. Suppressor T cells mask Peyer's patch B cell priming to orally administered antigen

1983 • 56 citations

Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice

1994 • 53 citations

The role of antigen recognition and suppressor cells in mice with oral tolerance to ovalbumin.

1985 • 53 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein VI. Suppression of adoptively transferred disease and differential effects of oral vs. intravenous tolerization

1993 • 52 citations

Mucosal tolerance is associated with, but independent of, up‐regulation Th2 responses

1997 • 50 citations

Oral Tolerance to Ovalbumin in Mice as a Model for Detecting Modulators of the Immunologic Tolerance to a Specific Antigen.

1995 • 48 citations

Depletion of suppressor T cells by 2'-deoxyguanosine abrogates tolerance in mice fed ovalbumin and permits the induction of intestinal delayed-type hypersensitivity.

1986 • 47 citations

Failure to Induce Oral Tolerance to Protein Antigens in Neonatal Mice Can Be Corrected by Transfer of Adult Spleen Cells

1989 • 45 citations

Modulation of oral tolerance to ovalbumin by cholera toxin and its B subunit

1992 • 44 citations

Anti‐IL‐10 Treatment Does Not Block Either the Induction or the Maintenance of Orally Induced Tolerance to Ova

1995 • 44 citations

Genetic differences in immune exclusion and partial tolerance to ingested antigens.

1983 • 42 citations

Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases

1991 • 40 citations

Dietary manipulation and induction of tolerance

1992 • 40 citations

Splenectomy abrogates the induction of oral tolerance in experimental autoimmune uveoretinitis

1993 • 40 citations

Suppression of an established DTH response to ovalbumin in mice by feeding antigen after immunization.

1988 • 39 citations

T-cell responses to orally administered antigens. Study of the kinetics of lymphokine production after single and multiple feeding.

1995 • 38 citations

CD8‐deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin

1996 • 38 citations

Lymphocytes from orally tolerized mice display enhanced susceptibility to death by apoptosis when cultured in the absence of antigen in vitro.

1996 • 37 citations

T-cell lymphokine response to orally administered proteins during priming and unresponsiveness.

1993 • 37 citations

Ontogeny of la messenger RNA in the mouse small intestinal epithelium is modulated by age of weaning and diet

1993 • 35 citations

Chemical Denaturation of Ovalbumin Abrogates the Induction of Oral Tolerance of Specific IgG Antibody and DTH Responses in Mice

1995 • 35 citations

Non-Sensitizing Epicutaneous Skin Tests Prevent Subsequent Induction of Immune Tolerance

1994 • 32 citations

Suppressor T cells, antigen-presenting cells and the role of I-J restriction in oral tolerance to ovalbumin.

1988 • 32 citations

Prevention of oral tolerance induction to ovalbumin and enhanced antigen presentation during a graft-versus-host reaction in mice.

1985 • 31 citations

Lymphocyte compartments in antigen-sampling regions of rabbit mucosal lymphoid organs.

1994 • 31 citations

Irradiated mice lose the capacity to 'process' fed antigen for systemic tolerance of delayed-type hypersensitivity.

1987 • 29 citations

Regulation of IgE Responses to Inhaled Antigens: Cellular Mechanisms Underlying Allergic Sensitization versus Tolerance Induction

1991 • 28 citations

The Role of Antigen Processing and Suppressor T Cells in Immune Responses to Dietary Proteins in Mice

1987 • 28 citations

Unique Features of Antigen Presentation in the Intestinea

1992 • 27 citations

Antigen‐specific TGF‐β1 Secretion with Bovine Myelin Oral Tolerization in Multiple Sclerosis

1996 • 23 citations

Oral tolerance in protein-deprived mice. II. Evidence of normal 'gut processing' of ovalbumin, but suppressor cell deficiency, in deprived mice.

1987 • 20 citations

Evidence That Type II Collagen Feeding Can Induce a Durable Therapeutic Response in Some Patients with Rheumatoid Arthritis

1996 • 19 citations

Oral Tolerance is Determined at the Level of Draining Lymph Nodes

1995 • 16 citations

Immunotherapy in autoimmune diseases

1991 • 16 citations

Type II collagen serology: a guide to clinical responsiveness to oral tolerance?

1997 • 15 citations

Oral tolerance in the control of experimental models of autoimmune disease.

1995 • 12 citations

Sensitization and development of tolerance via the gut

1993 • 11 citations

Differences in epitopes recognized by T cells during oral tolerance and priming

1994 • 10 citations

Mucosal immunity and the gut epithelium : interactions in health and disease

1995 • 9 citations

Different concentrations of thyroid peroxidase and thyroglobulin in the nuclear envelope and the endoplasmic reticulum throughout the cytoplasm.

1992 • 7 citations

Do organ-specific suppressor T cells prevent autoimmune gastritis?

1990 • 6 citations

Oral Tolerance

1996 • 6 citations

Oral tolerance: Of mice and men

1995 • 4 citations

Cytokines can make you sick—Or keep you well

1990 • 4 citations

Oral tolerance from a general perspective, and the possible role of side-effects in the gut

1995 • 1 citations

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