Autoreactive CD4+ T Cells Protect from Autoimmune Diabetes via Bystander Suppression Using the IL-4/Stat6 Pathway

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

1996 • 315 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

1990 • 288 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen.

1990 • 229 citations

Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.

1997 • 227 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

Interferon-γ Is Essential for Destruction of β Cells and Development of Insulin-dependent Diabetes Mellitus

1997 • 220 citations

IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis

1998 • 218 citations

T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction.

1995 • 171 citations

Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.

1995 • 167 citations

Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice

1998 • 163 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice.

1996 • 154 citations

CD4⁺ but not CD8⁺T cells are required for the induction of oral tolerance

1995 • 153 citations

Oral Administration of Human Insulin to NOD Mice Generates CD4+ T Cells that Suppress Adoptive Transfer of Diabetes

1994 • 137 citations

Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse.

1998 • 134 citations

Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis.

1996 • 124 citations

DNA immunization to prevent autoimmune diabetes

1999 • 123 citations

Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

1999 • 122 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction.

1994 • 121 citations

Signaling by the Cytokine Receptor Superfamily^a

1998 • 119 citations

Anti-γδ T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice

1995 • 118 citations

Oral Administration of the Immunodominant B-chain of Insulin Reduces Diabetes in a Co-transfer Model of Diabetes in the NOD Mouse and is Associated with a Switch from Th1 to Th2 Cytokines

1997 • 109 citations

Mature Mainstream TCRαβ+CD4+ Thymocytes Expressing L-Selectin Mediate “Active Tolerance” in the Nonobese Diabetic Mouse

1998 • 103 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

Pancreatic IL-4 Expression Results in Islet-Reactive Th2 Cells That Inhibit Diabetogenic Lymphocytes in the Nonobese Diabetic Mouse

1999 • 84 citations

Insulin in Oral Immune “Tolerance”: A One-Amino Acid Change in the B Chain Makes the Difference

1999 • 78 citations

Suppression of antigen‐induced arthritis in lewis rats by oral administration of type ii collagen

1995 • 67 citations

CD4+ beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice.

1995 • 57 citations

Evidence of CD4 + regulatory T cells in the non-obese diabetic male mouse

1994 • 55 citations

Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in the periphery and not in the eye

1995 • 45 citations

Oral Administration of Schistosome Egg Antigens and Insulin B-Chain Generates and Enhances Th2-Type Responses in NOD Mice

1998 • 38 citations

Induction of Oral Tolerance in Splenocyte-Reconstituted SCID Mice

1998 • 17 citations

The role of γδ TCR-bearing T cells in oral tolerance

1997 • 12 citations

Treatment of virus-induced autoimmune diabetes by oral administration of insulin: Study on the mechanism by which oral antigens can abrogate autoimmunity

2009 • 7 citations