Characterization of genomic BCR‐ABL breakpoints in chronic myeloid leukaemia by PCR

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

PRE-mRNA SPLICING

1986 • 673 citations

A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones

1990 • 650 citations

An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders.

1994 • 259 citations

Detection of chimeric BCR-ABL genes in acute lymphoblastic leukaemia by the polymerase chain reaction

1991 • 247 citations

A Common Mechanism of Chromosomal Translocation in T- and B-Cell Neoplasia

1986 • 205 citations

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

1993 • 183 citations

Insertion and/or deletion of many repeated DNA sequences in human and higher ape evolution.

1986 • 183 citations

Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours.

1989 • 160 citations

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

1993 • 150 citations

Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of theBCRgene

1989 • 138 citations

DNA topoisomerase I and II as targets for rational design of new anticancer drugs

1993 • 121 citations

The human minisatellite consensus at breakpoints of oncogene translocations

1990 • 111 citations

Frequent and extensive deletion during the 9,22 translocation in CML

1986 • 81 citations

Molecular analysis of both translocation products of a Philadelphia-positive CML patient

1986 • 78 citations

Ph1+bcr- acute leukemias: implication of Alu sequences in a chromosomal translocation occurring in the new cluster region within the BCR gene.

1989 • 66 citations

Breakpoint clusters of the PML gene in acute promyelocytic leukemia: Primary structure of the reciprocal products of the PML‐RARA gene in a patient with t(15;17)

1993 • 55 citations

The position of the M‐BCR breakpoint does not predict the duration of chronic phase or survival in chronic myeloid leukaemia

1990 • 54 citations

The BCR/ABL hybrid gene

1987 • 49 citations

Mechanism of the chromosomal translocation t(14;18) in lymphoma: detection of a 45-Kd breakpoint binding protein

1993 • 43 citations

DNA topoisomerase II cleaves at specific sites in the 5′ flanking region of c-fos proto-oncogenes in vitro.

1986 • 42 citations

Characterization of the translocation breakpoint sequences in philadelphia‐positive acute lymphoblastic leukemia

1990 • 41 citations

Ph1-positive, bcr-negative acute leukemias: clustering of breakpoints on chromosome 22 in the 3′ end of the BCR gene first intron

1989 • 33 citations

Chromosomal breakpoints within the first intron of the ABL gene are nonrandom in patients with chronic myelogenous leukemia

1990 • 31 citations

DNA sequence analysis of the major breakpoint cluster region of the BCR gene rearranged in Philadelphia-positive human leukemias.

1993 • 30 citations

Mapping of breakpoints, and relationship to BCR-ABL RNA expression, in Philadelphia-chromosome-positive chronic myeloid leukaemia patients with a breakpoint around exon 14 (b3) of the BCR gene.

1991 • 28 citations

Induction of BCR‐ABL Fusion Genes by in vitro X‐irradiation

1993 • 26 citations

Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia

1993 • 15 citations

Amplification and sequencing of genomic breakpoints located within the M-bcr region by Vectorette-mediated polymerase chain reaction.

1992 • 12 citations

Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination

1993 • 9 citations

Sequence‐specific DNA‐binding proteins within the Mbcr on the ph1 chromosome

1991 • 4 citations