The BCR/ABL hybrid gene

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

The Chromosomal Basis of Human Neoplasia

1983 • 1,121 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene

1986 • 820 citations

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

1983 • 743 citations

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

1982 • 680 citations

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

1982 • 675 citations

Expression of cellular homologues of retroviral onc genes in human hematopoietic cells.

1982 • 570 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

1980 • 474 citations

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

1987 • 448 citations

The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages

1983 • 415 citations

Lymphosarcoma: virus-induced thymic-independent disease in mice.

1970 • 414 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

A single mouse α-amylase gene specifies two different tissue-specific mRNAs

1981 • 402 citations

Unique Forms of the abl Tyrosine Kinase Distinguish Ph ¹ -Positive CML from Ph ¹ -Positive ALL

1987 • 344 citations

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

1985 • 314 citations

Chromosomal localization of human cellular homologues of two viral oncogenes

1982 • 304 citations

Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes

1982 • 292 citations

Alternative 5′ exons in c-abl mRNA

1986 • 290 citations

Direct transformation of 3T3 cells by Abelson murine leukaemia virus

1975 • 288 citations

Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts

1983 • 286 citations

Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter

1986 • 281 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

Evidence of a New Chimericbcr/c-ablmRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome

1985 • 253 citations

Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

1983 • 253 citations

Chronic myelogenous leukemia: recent advances

1985 • 247 citations

In vitro transformation of lymphoid cells by Abelson murine leukemia virus.

1975 • 247 citations

Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.

1983 • 244 citations

The mouse c-abl locus: Molecular cloning and characterization

1984 • 223 citations

Altered Transcription of the c- abl Oncogene in K-562 and Other Chronic Myelogenous Leukemia Cells

1984 • 209 citations

Trans splicing of mRNA precursors

1985 • 205 citations

The Chronic Myelocytic Cell Line K562 Contains a Breakpoint in bcr and Produces a Chimeric bcr/c-abl Transcript

1986 • 192 citations

Chronic myelogenous leukemia: recent advances

1985 • 190 citations

bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia

1986 • 186 citations

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

1986 • 160 citations

Expression of the mouse HPRT gene: Deletional analysis of the promoter region of an X-Chromosome linked housekeeping gene

1986 • 160 citations

A human onc gene homologous to the transforming gene (v-sis) of simian sarcoma virus

1981 • 156 citations

ALTERED TRANSCRIPTION OF AN ONCOGENE IN CHRONIC MYELOID LEUKAEMIA

1984 • 156 citations

Genomic diversity correlates with clinical variation in Ph′-negative chronic myeloid leukaemia

1986 • 145 citations

C-abl and bcr are rearranged in a Ph1-negative CML patient.

1985 • 144 citations

A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity.

1980 • 132 citations

Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components.

1978 • 132 citations

The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.

1986 • 128 citations

Evidence against a scanning model of RNA splicing.

1983 • 122 citations

cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

1987 • 107 citations

c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia.

1983 • 105 citations

Rearrangement of the bcr Gene in Philadelphia-Chromosome-Negative Chronic Myeloid Leukemia

1987 • 103 citations

Localization of the human c-sis oncogene in Ph1-positive and Ph1- negative chronic myelocytic leukemia by in situ hybridization

1984 • 101 citations

Expression of an Abelson murine leukemia virus-encoded protein in Escherichia coli causes extensive phosphorylation of tyrosine residues.

1982 • 99 citations

Blast Crisis of Chronic Myeloid Leukaemia (CML): I. PRESENTATION SIMULATING ACUTE LYMPHOID LEUKAEMIA (ALL)

1976 • 95 citations

Alternative Splicing of a Drosophila Tropomyosin Gene Generates Muscle Tropomyosin Isoforms with Different Carboxy-Terminal Ends

1984 • 91 citations

Structure of the abelson murine leukemia virus genome

1979 • 88 citations

Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products

1983 • 86 citations

Rearrangement of the bcr gene in Philadelphia chromosome-negative chronic myeloid leukemia

1986 • 85 citations

Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity.

1987 • 84 citations

Molecular analysis of both translocation products of a Philadelphia-positive CML patient

1986 • 78 citations

The Ph¹ Chromosome in Childhood Leukaemia

1979 • 70 citations

Switching of subunit composition of muscle spectrin during myogenesis in vitro

1983 • 64 citations

The human v-abl cellular homologue.

1983 • 64 citations

THE MOLECULAR BIOLOGY OF CHRONIC MYELOGENOUS LEUKAEMIA

1985 • 60 citations

Variable breakpoints on the Philadelphia chromosome in chronic myelogenous leukemia

1985 • 58 citations

Alternative splicing of a Drosophila tropomyosin gene generates muscle tropomyosin isoforms with different carboxy-terminal ends.

1984 • 56 citations

Isolation of Human Oncogene Sequences (v- fes Homolog) from a Cosmid Library

1982 • 52 citations

Chromosomes and causation of human cancer and leukemia.XXV. Significance of the Ph1 (including unusual translocations) in various acute leukemias

1977 • 40 citations

Rapid progress in chronic myelogenous leukemia.

1988 • 39 citations

Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia.

1987 • 35 citations

Splicing in Adenovirus and Other Animal Viruses

1985 • 15 citations

Historical portraits of the underdog

1987 • 6 citations