Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[1] Production of single-stranded plasmid DNA

1987 • 2,642 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants

1964 • 2,108 citations

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 1,618 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

λ ZAP: a bacteriophage λ expression vector within vivoexcision properties

1988 • 1,394 citations

9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

1978 • 1,136 citations

Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus

1980 • 603 citations

GENETICS OF HUMAN CANCER

1986 • 565 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

Antiviral Activity and Mechanism of Action of Ganciclovir

1988 • 354 citations

Handbook of cell and organ culture

1964 • 353 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

Mutagenesis by transient misalignment.

1988 • 265 citations

Structural intermediates of deletion mutagenesis: a role for palindromic DNA.

1984 • 251 citations

Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.

1983 • 247 citations

Association of Crossover Points with Topoisomerase I Cleavage Sites: A Model for Nonhomologous Recombination

1985 • 218 citations

Non‐producer human cells induced by murine sarcoma virus

1975 • 204 citations

Preferential deletion of exons in Duchenne and Becker muscular dystrophies

1987 • 201 citations

1982 supplement to DNA replication

1983 • 179 citations

The Chinese hamster Alu-equivalent sequence: a conserved highly repetitious, interspersed deoxyribonucleic acid sequence in mammals has a structure suggestive of a transposable element.

1981 • 157 citations

Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

1986 • 150 citations

Evidence that the 'Active Centre' of the Herpes Simplex Virus Thymidine Kinase Involves an Interaction between Three Distinct Regions of the Polypeptide

1986 • 149 citations

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations

1985 • 146 citations

Disease Diagnosis by Recombinant DNA Methods

1987 • 135 citations

Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases

1981 • 134 citations

SPONTANEOUS MUTATION

1991 • 131 citations

Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus.

1975 • 107 citations

Involvement of Double-strand Chromosomal Breaks for Mating-type Switching in Saccharomyces cerevisiae

1984 • 98 citations

Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level.

1988 • 95 citations

Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene

1983 • 94 citations

Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: Effects on catalytic activity

1988 • 92 citations

Mutations and epimutations in mammalian cells

1991 • 86 citations

Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells

1990 • 83 citations

Molecular basis of spontaneous mutation at the aprt locus of hamster cells

1989 • 83 citations

RELATIVE POTENCIES OF ANTI‐HERPES COMPOUNDS

1977 • 76 citations

Evolution of the herpes thymidine kinase: identification and comparison of the equine herpesvirus 1 thymidine kinase gene reveals similarity to a cell-encoded thymidylate kinase

1988 • 71 citations

DNA sequence analysis of spontaneous mutations at the aprt locus of hamster cells.

1987 • 71 citations

Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses

1991 • 70 citations

Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir

1987 • 62 citations

The aprt heterozygote/hemizygote system for screening mutagenic agents allows detection of large deletions

1988 • 36 citations

Spectrum of spontaneous mutations in a cDNA of the human hprt gene integrated in chromosomal DNA

1989 • 36 citations

Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2′-deoxyuridine analogs in the Ames Salmonella/microsome test

1986 • 33 citations

Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells

1991 • 31 citations

The nature of spontaneous mutations

1989 • 23 citations

Purification and crystallization of thymidine kinase from herpes simplex virus type 1

1988 • 19 citations

Loss of heterozygosity in mammalian cell mntagenesis: molecular analysis of spontaneous mutations at the aprt locus in CHO cells

1990 • 19 citations

Endogenous gene systems for the study of mutational specificity in mammalian cells.

1990 • 18 citations

HEp-2 Cell- and Herpes Simplex Virus Type 1- Induced Deoxythymidine Kinases: Inhibition by Derivatives of 5-Trifluoromethyl-2′-Deoxyuridine

1978 • 17 citations

Molecular mechanisms of the formation of DNA double-strand breaks and induction of genomic rearrangements

1992 • 14 citations

Effects of nucleoside analogues on the expression of herpes simplex type 1-induced proteins

1982 • 13 citations

Analysis of spontaneous mutations in a chromosomally located hsv-1 thymidine kinase (TK) gene in a human cell line

1987 • 7 citations

A cytotoxic effect associated with 9-(1,3-dihydroxy-2-propoxymethyl)-guanine is observed during the selection for drug resistant human cells containing a single herpesvirus thymidine kinase gene

1985 • 6 citations

The recognition of DNA cleavage sites by porcine splean topoisomeraseII topoisomerase II

1992 • 4 citations