The ins and outs of IgE-dependent mast-cell exocytosis

Calmodulin: a prototypical calcium sensor

2000 • 1,445 citations

Membrane Fusion and Exocytosis

1999 • 1,252 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Fundamental Immunology

1999 • 1,011 citations

THE HIGH-AFFINITY I<scp>g</scp>E RECEPTOR (FcεRI): From Physiology to Pathology

1999 • 949 citations

Protein kinase C

1991 • 914 citations

Signalling through the high-affinity IgE receptor FcεRI

1999 • 730 citations

A genomic perspective on membrane compartment organization

2001 • 693 citations

Regulation of mast-cell and basophil function and survival by IgE

2002 • 626 citations

Snares and munc18 in synaptic vesicle fusion

2002 • 537 citations

Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion

2001 • 513 citations

Synaptotagmin: A Ca2+ sensor that triggers exocytosis?

2002 • 464 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Roles of mast cells and basophils in innate and acquired immunity

2000 • 350 citations

LAT Is Essential for FcεRI-Mediated Mast Cell Activation

2000 • 332 citations

Emerging Roles of Presynaptic Proteins in Ca ⁺⁺ -Triggered Exocytosis

2002 • 319 citations

Essential role for Gab2 in the allergic response

2001 • 306 citations

Phosphorylation of Munc-18/n-Sec1/rbSec1 by Protein Kinase C

1996 • 262 citations

Relocation of the t-SNARE SNAP-23 from Lamellipodia-like Cell Surface Projections Regulates Compound Exocytosis in Mast Cells

1998 • 254 citations

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI

2003 • 254 citations

Phosphorylation of 25-kDa Synaptosome-associated Protein

1996 • 248 citations

Soluble NSF Attachment Protein Receptors (SNAREs) in RBL-2H3 Mast Cells: Functional Role of Syntaxin 4 in Exocytosis and Identification of a Vesicle-Associated Membrane Protein 8-Containing Secretory Compartment

2000 • 218 citations

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcϵRI and LAT

2001 • 177 citations

Differential Phosphorylation of Syntaxin and Synaptosome‐Associated Protein of 25 kDa (SNAP‐25) Isoforms

1999 • 176 citations

Structure-Function Analysis of Lyn Kinase Association with Lipid Rafts and Initiation of Early Signaling Events after Fcɛ Receptor I Aggregation

2001 • 175 citations

Molecular adapters in FcεRI signaling and the allergic response

2002 • 166 citations

Rabs grab motors: defining the connections between Rab GTPases and motor proteins

2002 • 166 citations

Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells

2002 • 164 citations

Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation

2000 • 164 citations

Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.

1997 • 163 citations

Control of the Terminal Step of Intracellular Membrane Fusion by Protein Phosphatase 1

1999 • 161 citations

An Unusual Mechanism for Ligand Antagonism

1998 • 157 citations

Preferential Signaling and Induction of Allergy-promoting Lymphokines Upon Weak Stimulation of the High Affinity IgE Receptor on Mast Cells

2003 • 141 citations

Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules

2002 • 134 citations

Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis

2002 • 131 citations

Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation

2002 • 131 citations

Phospholipases D1 and D2 Regulate Different Phases of Exocytosis in Mast Cells

2002 • 130 citations

Fusion pore expansion in horse eosinophils is modulated by Ca2+ and protein kinase C via distinct mechanisms

1998 • 120 citations

The Phospholipase Cγ1-dependent Pathway of FcϵRI-mediated Mast Cell Activation Is Regulated Independently of Phosphatidylinositol 3-Kinase

2003 • 109 citations

Continual Production of Phosphatidic Acid by Phospholipase D Is Essential for Antigen-stimulated Membrane Ruffling in Cultured Mast Cells

2002 • 108 citations

Transmodulation between Phospholipase D and c-Src Enhances Cell Proliferation

2003 • 100 citations

FcϵRI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells

2001 • 99 citations

Microtubule‐Dependent Transport of Secretory Vesicles in RBL‐2H3 Cells

2003 • 99 citations

Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C.

1994 • 99 citations

Measurement of exocytosis by amperometry in adrenal chromaffin cells: Effects of clostridial neurotoxins and activation of protein kinase C on fusion pore kinetics

2000 • 98 citations

Protein Kinase C Phosphorylation of Syntaxin 4 in Thrombin-activated Human Platelets

2000 • 91 citations

Protein Kinase Cδ Induces Src Kinase Activity via Activation of the Protein Tyrosine Phosphatase PTPα

2003 • 91 citations

The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcεRI-mediated Mast Cell Activation

2003 • 85 citations

Mast Cell Degranulation RequiresN-Ethylmaleimide-Sensitive Factor-Mediated SNARE Disassembly

2003 • 69 citations

Effects of latrunculin reveal requirements for the actin cytoskeleton during secretion from mast cells

2000 • 68 citations

SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line

2002 • 65 citations

Regulation of human PLD1 and PLD2 by calcium and protein kinase C

2000 • 65 citations

Evidence for an early appearance of modern post-switch immunoglobulin isotypes in mammalian evolution (II); cloning of IgE, IgG1 and IgG2 from a monotreme, the duck-billed platypus, Ornithorhynchus anatinus

2002 • 59 citations

Enlargement of Secretory Vesicles by Protein Tyrosine Phosphatase PTP-MEG2 in Rat Basophilic Leukemia Mast Cells and Jurkat T Cells

2002 • 55 citations

Classical and Alternative Pathways of Mast Cell Activation

2002 • 51 citations

Transient Translocation and Activation of Protein Phosphatase 2A during Mast Cell Secretion

2000 • 50 citations

Unexpected signals in a system subject to kinetic proofreading

2001 • 50 citations

p110β and p110δ Phosphatidylinositol 3-Kinases Up-regulate FcεRI-activated Ca2+ Influx by Enhancing Inositol 1,4,5-Trisphosphate Production

2001 • 47 citations

Thirty years of stimulus-secretion coupling: From Ca2+ toGTP in the regulation of exocytosis

2000 • 43 citations

Calmodulin regulates the disassembly of cortical F-actin in mast cells but is not required for secretion

2000 • 43 citations

IgE Receptor Type I-dependent Regulation of a Rab3D-associated Kinase

2001 • 43 citations

Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules

2003 • 42 citations

Distinct Phosphoinositide 3-Kinases Mediate Mast Cell Degranulation in Response to G-protein-coupled VersusFcεRI Receptors

2003 • 41 citations

Phospholipase D and immune receptor signalling

2002 • 41 citations

Synaptotagmin regulates mast cell functions

2001 • 40 citations

Interaction between the Unphosphorylated Receptor with High Affinity for IgE and Lyn Kinase

2001 • 40 citations

Calmodulin‐dependent regulation of a lipid binding domain in the v‐SNARE synaptobrevin and its role in vesicular fusion

2003 • 40 citations

Phospholipase C, Protein Kinase C, Ca²⁺/Calmodulin‐Dependent Protein Kinase II, and Tyrosine Phosphorylation Are Involved in Carbachol‐Induced Phospholipase D Activation in Chinese Hamster Ovary Cells Expressing Muscarinic Acetylcholine Receptor of Caenorhabditis elegans

2000 • 39 citations

Phosphorylation of SNAP-23 by the Novel Kinase SNAK Regulates t-SNARE Complex Assembly

1999 • 33 citations

Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells

2002 • 33 citations

Calcium-dependent Threonine Phosphorylation of Nonmuscle Myosin in Stimulated RBL-2H3 Mast Cells

2000 • 20 citations

Nonreceptor Protein Tyrosine and Lipid Phosphatases in Type I Fcε Receptor-Mediated Activation of Mast Cells and Basophils

2002 • 16 citations

The roles of calmodulin and protein kinase C in histamine secretion from mast cells.

1992 • 14 citations

Intestinal anaphylaxis in chickens: epithelial ion secretion as a determinant and potential component of functional immunity

2001 • 8 citations