The Insulin Receptor Catalyzes the Tyrosine Phosphorylation of Caveolin-1

Lipid rafts and signal transduction

2000 • 6,079 citations

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

The insulin signaling system.

1994 • 1,733 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Src Tyrosine Kinases, Gα Subunits, and H-Ras Share a Common Membrane-anchored Scaffolding Protein, Caveolin

1996 • 770 citations

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

1996 • 677 citations

Endothelial Nitric Oxide Synthase Targeting to Caveolae

1996 • 670 citations

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

2000 • 646 citations

Insulin signaling pathways in time and space

2002 • 630 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

2001 • 606 citations

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

2000 • 519 citations

Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin.

1995 • 499 citations

Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles.

1994 • 413 citations

Localization of Platelet-derived Growth Factor-stimulated Phosphorylation Cascade to Caveolae

1996 • 378 citations

Segregation of Heterotrimeric G Proteins in Cell Surface Microdomains

2001 • 370 citations

The lipid phosphatase SHIP2 controls insulin sensitivity

2001 • 369 citations

Localization of the insulin receptor in caveolae of adipocyte plasma membrane

1999 • 364 citations

Tyrosine Phosphorylation of a 22-kDa Protein Is Correlated with Transformation by Rous Sarcoma Virus

1989 • 363 citations

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

2001 • 348 citations

Phosphorylation of Caveolin by Src Tyrosine Kinases

1996 • 347 citations

Constitutive and Growth Factor-Regulated Phosphorylation of Caveolin-1 Occurs at the Same Site (Tyr-14) in Vivo: Identification of a c-Src/Cav-1/Grb7 Signaling Cassette

2000 • 320 citations

EGF-R signaling through Fyn kinase disrupts the function of integrin α6β4 at hemidesmosomes

2001 • 306 citations

Caveolin Is an Activator of Insulin Receptor Signaling

1998 • 297 citations

Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line

1990 • 285 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

A Novel, Multifunctional c-Cbl Binding Protein in Insulin Receptor Signaling in 3T3-L1 Adipocytes

1998 • 216 citations

Insulin stimulates the tyrosine phosphorylation of caveolin.

1995 • 215 citations

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

1990 • 202 citations

The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes

2000 • 190 citations

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation

2001 • 171 citations

Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes

2000 • 170 citations

APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes

2002 • 167 citations

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1997 • 155 citations

The sorbin homology domain: A motif for the targeting of proteins to lipid rafts

2001 • 151 citations

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.

1995 • 149 citations

Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 149 citations

Activation of Mitogen-activated Protein Kinase and Phosphatidylinositol 3′-Kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake, Lipogenesis, or Glycogen Synthesis in 3T3-L1 Adipocytes

1995 • 148 citations

Insulin-stimulated Tyrosine Phosphorylation of Caveolin Is Specific for the Differentiated Adipocyte Phenotype in 3T3-L1 Cells

1997 • 143 citations

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

1996 • 132 citations

Stimulation of IRS-1-associated Phosphatidylinositol 3-Kinase and Akt/Protein Kinase B but Not Glucose Transport by β1-Integrin Signaling in Rat Adipocytes

1998 • 122 citations

Identification of Wortmannin-sensitive Targets in 3T3-L1 Adipocytes

1999 • 99 citations

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin's Metabolic and Mitogenic Effects

1997 • 92 citations

The Insulin Receptor and Its Substrate: Molecular Determinants of Early Events in Insulin Action

1993 • 92 citations

Dual Role of Fyn in the Regulation of FAK+6,7 by Cannabinoids in Hippocampus

2001 • 54 citations

Insulin-Induced Protein Tyrosine Phosphorylation Cascade and Signalling Molecules Are Localized in a Caveolin-Enriched Cell Membrane Domain

1998 • 53 citations