Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G₀/G₁Arrest via a p53/p21^WAF1/Cip1-dependent Mechanism

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Caveolins, Liquid-Ordered Domains, and Signal Transduction

1999 • 1,016 citations

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains

1996 • 1,006 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

1997 • 808 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Src Tyrosine Kinases, Gα Subunits, and H-Ras Share a Common Membrane-anchored Scaffolding Protein, Caveolin

1996 • 770 citations

Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle

1996 • 737 citations

Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells

1996 • 692 citations

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

1996 • 677 citations

Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins

1997 • 658 citations

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

1997 • 647 citations

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

1994 • 646 citations

Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

1995 • 612 citations

GADD45 induction of a G ₂ /M cell cycle checkpoint

1999 • 607 citations

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

1996 • 566 citations

The plasma membrane

1983 • 561 citations

Caveolae and caveolins

1996 • 549 citations

Oligomeric structure of caveolin: implications for caveolae membrane organization.

1995 • 547 citations

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles.

1992 • 544 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

Reduction of caveolin and caveolae in oncogenically transformed cells.

1995 • 505 citations

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1998 • 473 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

1998 • 435 citations

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1998 • 421 citations

Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles.

1994 • 413 citations

Recombinant Expression of Caveolin-1 in Oncogenically Transformed Cells Abrogates Anchorage-independent Growth

1997 • 377 citations

Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo

1998 • 371 citations

Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts.

1992 • 369 citations

Tyrosine Phosphorylation of a 22-kDa Protein Is Correlated with Transformation by Rous Sarcoma Virus

1989 • 363 citations

Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer

1998 • 343 citations

Mechanisms of p53-mediated apoptosis

1999 • 303 citations

Genes encoding human caveolin‐1 and ‐2 are co‐localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

1998 • 227 citations

Invasion activating caveolin-1 mutation in human scirrhous breast cancers.

2001 • 225 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles

1992 • 223 citations

Expression and Characterization of Recombinant Caveolin

1996 • 223 citations

Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo

1998 • 215 citations

Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide

2000 • 194 citations

A Molecular Dissection of Caveolin-1 Membrane Attachment and Oligomerization

2000 • 192 citations

Caveolin-1 Expression Inhibits Wnt/β-Catenin/Lef-1 Signaling by Recruiting β-Catenin to Caveolae Membrane Domains

2000 • 185 citations

Molecular Genetics of the Caveolin Gene Family: Implications for Human Cancers, Diabetes, Alzheimer Disease, and Muscular Dystrophy

1998 • 184 citations

A photo‐reactive derivative of ganglioside GM1 specifically cross‐links VIP21‐caveolin on the cell surface

1995 • 181 citations

Regulation of cAMP-mediated Signal Transduction via Interaction of Caveolins with the Catalytic Subunit of Protein Kinase A

1999 • 178 citations

p21/p53, Cellular Growth Control and Genomic Integrity

1998 • 177 citations

Caveolae and caveolin-3 in muscular dystrophy

2001 • 159 citations

Phenotypic Behavior of Caveolin-3 Mutations That Cause Autosomal Dominant Limb Girdle Muscular Dystrophy (LGMD-1C)

1999 • 158 citations

Inactivation of p53 gene in human and murine osteosarcoma cells

1992 • 157 citations

Carcinogenesis: A balance between β-catenin and APC

1997 • 154 citations

Sequence and detailed organization of the human caveolin‐1 and ‐2 genes located near the D7S522 locus (7q31.1)

1999 • 151 citations

Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav‐1, ‐2, and ‐3)

1998 • 144 citations

The Cardiovascular System

1983 • 137 citations

RNA Genetics of Breast Cancer: Maspin as Paradigm

1994 • 123 citations

Molecular and Cellular Biology of Caveolae

1997 • 120 citations

Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle.

1991 • 119 citations

Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy

2000 • 112 citations

p53 Regulates Caveolin Gene Transcription, Cell Cholesterol, and Growth by a Novel Mechanism

2000 • 102 citations

Caveolin-1 Expression Is Down-Regulated in Cells Transformed by the Human Papilloma Virus in a p53-Dependent Manner. Replacement of Caveolin-1 Expression Suppresses HPV-Mediated Cell Transformation

2000 • 94 citations

Visualization of caveolin‐1, a caveolar marker protein, in living cells using green fluorescent protein (GFP) chimeras

1999 • 65 citations

Apoptosis by p53: mechanisms, regulation, and clinical implications

1998 • 30 citations

The Accumulation of Cyclin-Dependent Kinase Inhibitor p27kip1Is a Primary Response to Staurosporine and Independent of G1 Cell Cycle Arrest

1998 • 23 citations