Inhibition of Streptomyces hydrogenans 3α,20β-hydroxysteroid dehydrogenase by licorice-derived compounds and crystallization of an enzyme-cofactor-inhibitor complex

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

Preparation and analysis of protein crystals

1982 • 976 citations

Cloning and Expression of Rat cDNA Encoding Corticosteroid 11β-Dehydrogenase

1989 • 452 citations

Characteristics of short‐chain alcohol dehydrogenases and related enzymes

1991 • 452 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Preparation and analysis of protein crystals

1982 • 366 citations

Licorice Inhibits Corticosteroid 1lβ-Dehydrogenase of Rat Kidney and Liver:In Vivoandin VitroStudies*

1989 • 306 citations

Complete amino acid sequence of human placental 17β‐hydroxysteroid dehydrogenase deduced from cDNA

1988 • 298 citations

Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family.

1991 • 232 citations

Medicinal uses of licorice through the millennia: The good and plenty of it

1991 • 135 citations

Purification and structural characterization of placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family

1990 • 105 citations

Corticosteroids, receptors, and the organ‐specific functions of 11 β ‐hydroxysteroid dehydrogenase

1991 • 104 citations

Prokaryotic 20β-hydroxysteroid dehydrogenase is an enzyme of the ‘short-chain, non-metalloenzyme’ alcohol dehydrogenase type

1990 • 85 citations

Bifunctional enzyme activity at the same active site: study of 3.alpha. and 20.beta. activity by affinity alkylation of 3.alpha.,20.beta.-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids

1980 • 77 citations

Affinity Labeling of Steroid Binding Sites

1971 • 57 citations

Effect of carbenoxolone on prostaglandin synthesis and degradation

1976 • 48 citations

Genealogy of regulation of human sex and adrenal function, prostaglandin action, snapdragon and petunia flower colors, antibiotics, and nitrogen fixation: functional diversity from two ancestral dehydrogenases

1991 • 46 citations

Comparison of the 3α- and 20β-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans

1978 • 30 citations

Licorice, computer-based analyses of dehydrogenase sequences, and the regulation of steroid and prostaglandin action

1991 • 30 citations

Corticosteroids, kidneys, sweet roots and dirty drugs

1991 • 23 citations

Chemical modification of 3.alpha.,20.beta.-hydroxysteroid dehydrogenase with diethyl pyrocarbonate. Evidence for an essential, highly reactive, lysyl residue

1987 • 22 citations

Affinity labeling of steroid binding sites. Synthesis of 21-bromoacetylaminoprogesterone and study of 20beta-hydroxysteroid dehydrogenase.

1978 • 19 citations

Structural Features of Ring A and the Interaction of 20‐Oxosteroids with Cortisone Reductase

1972 • 14 citations

Structural features of ring C of 20-oxo steroids and the interaction with cortisone reductase

1974 • 6 citations