Recent developments in the pharmacological management of pain in children

α2-Adrenergic Agonists for Regional Anesthesia

1996 • 924 citations

Sucrose for analgesia in newborn infants undergoing painful procedures

2004 • 816 citations

Tramadol

2000 • 641 citations

Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial

2004 • 540 citations

Ketamine as Adjuvant Analgesic to Opioids: A Quantitative and Qualitative Systematic Review

2004 • 502 citations

Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain

2005 • 456 citations

Analgesia and Sedation in Preterm Neonates Who Require Ventilatory Support

1999 • 425 citations

Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes

2002 • 292 citations

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children

2004 • 281 citations

Genetic Predictors of the Clinical Response to Opioid Analgesics

2004 • 253 citations

Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients.

1992 • 244 citations

Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients.

1992 • 241 citations

Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration

2004 • 236 citations

Scaling for size: some implications for paediatric anaesthesia dosing

2002 • 190 citations

The role of the N-methyl-d-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture

2005 • 187 citations

Anesthetic Agents and the Immature Brain: Are These Toxic or Therapeutic?

2004 • 175 citations

Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms*1

2004 • 173 citations

Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy

2005 • 166 citations

Morphine, Hypotension, and Adverse Outcomes Among Preterm Neonates: Who’s to Blame? Secondary Results From the NEOPAIN Trial

2005 • 165 citations

How individual sensitivity to opiates can be predicted by gene analyses

2005 • 160 citations

Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis¹

2005 • 159 citations

Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus

2001 • 153 citations

Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy

2001 • 145 citations

Prevention of intraventricular hemorrhage by indomethacin in male preterm infants

2004 • 137 citations

Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children*

2005 • 129 citations

Continuous Peripheral Nerve Blocks at Home for Treatment of Recurrent Complex Regional Pain Syndrome I in Children

2005 • 124 citations

Selective COX-2 Inhibitors and Risk of Myocardial Infarction

2005 • 122 citations

Pharmacokinetics and protein binding of intravenous ibuprofen in the premature newborn infant

1997 • 120 citations

Clonidine vs. midazolam as premedication in children undergoing adeno‐tonsillectomy: A prospective, randomized, controlled clinical trial

2004 • 119 citations

Tolerance and analgesic efficacy of a new i.v. paracetamol solution in children after inguinal hernia repair

2005 • 115 citations

Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates

2004 • 113 citations

Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P -450 2D6 activity

2005 • 113 citations

Pain management in the neonatal intensive care unit: a national survey in Italy

2005 • 108 citations

Dexmedetomidine in the Treatment of Withdrawal Syndromes in Cardiothoracic Surgery Patients

2005 • 95 citations

Ketamine and kids: an update

2005 • 93 citations

Prospective randomized trial of ketorolac after congenital heart surgery

2004 • 92 citations

Prolonged infusion of dexmedetomidine for sedation following tracheal resection

2005 • 91 citations

Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age

2004 • 87 citations

An Evaluation of the Safety and Efficacy of Administering Rofecoxib for Postoperative Pain Management

2003 • 87 citations

A brainstem substrate for analgesia elicited by intraoral sucrose

2005 • 84 citations

Limited predictability of amikacin clearance in extreme premature neonates at birth

2005 • 78 citations

The use of dexmedetomidine to facilitate acute discontinuation of opioids after cardiac transplantation in children*

2005 • 75 citations

Use of tramadol in children

2005 • 72 citations

Analgesic effects of oral sucrose and pacifier during eye examinations for retinopathy of prematurity

2004 • 71 citations

Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus

2001 • 71 citations

Opioid Rotation in Children with Cancer

2004 • 69 citations

Morphine pharmacokinetics during venoarterial extracorporeal membrane oxygenation in neonates

2005 • 68 citations

Effects of Co-Administration of Ibuprofen-Lysine on the Pharmacokinetics of Amikacin in Preterm Infants during the First Days of Life

2004 • 68 citations

Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry

2004 • 68 citations

Analgesia for adenotonsillectomy in children: a comparison of morphine, ketamine and tramadol

2004 • 67 citations

Rescue sedation with dexmedetomidine for diagnostic imaging: a preliminary report

2005 • 66 citations

Pharmacokinetics of Clonidine after Rectal Administration in Children

1994 • 65 citations

Intraoperative low‐dose S‐ketamine has no preventive effects on postoperative pain and morphine consumption after major urological surgery in children

2005 • 64 citations

Complex Regional Pain Syndromes in Children and Adolescents

2005 • 61 citations

Intravenous Ketamine Infusion as an Adjuvant to Morphine in a 2-Year-Old With Severe Cancer Pain From Metastatic Neuroblastoma

2004 • 59 citations

Plasma levels of clonidine following epidural bolus injection in children

1998 • 59 citations

Genetics and variability in opioid response

2004 • 50 citations

A comparison of the effect of nitroparacetamol and paracetamol on liver injury

2001 • 50 citations

Ibuprofen and cerebral oxygenation and circulation

2004 • 48 citations

The effects of tramadol on postoperative nausea, vomiting and headache after ENT surgery. A placebo‐controlled comparison with equipotent doses of nalbuphine and pethidine

1999 • 47 citations

Long‐acting morphine for pain control in paediatric oncology

2001 • 43 citations

Dexmedetomidine as the primary sedative agent for brain radiation therapy in a 21‐month old child

2005 • 39 citations

Sugar Solution Analgesia: The Effects of Glucose on Expressed Mu Opioid Receptors

2005 • 39 citations

Population Pharmacokinetics of Ibuprofen Enantiomers in Very Premature Neonates

2004 • 38 citations

The impact of ibuprofen on renal clearance in preterm infants is independent of the gestational age

2005 • 37 citations

A Teenager with Severe Asthma Exacerbation following Ibuprofen

2005 • 37 citations

Pharmacokinetics of rectal tramadol in postoperative paediatric patients

2004 • 36 citations

Intravenous indometacin in preterm infants with symptomatic patent ductus arteriosus. A population pharmacokinetic study

2004 • 36 citations

Rofecoxib administration to paediatric patients undergoing adenotonsillectomy

2004 • 35 citations

Comparison of caudal ropivacaine, ropivacaine plus ketamine and ropivacaine plus tramadol administration for postoperative analgesia in children

2004 • 35 citations

The pharmacokinetics of ibuprofen suspension, chewable tablets, and tablets in children with cystic fibrosis

1999 • 33 citations

Acetaminophen in cerebrospinal fluid in children

2003 • 33 citations

Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTED

2004 • 32 citations

CBT in paediatric and adolescent health settings: A review of practice-based evidence

2005 • 32 citations

Nitric oxide releasing acetaminophen (nitroacetaminophen)

2003 • 32 citations

The safety of ibuprofen suspension in children.

2003 • 31 citations

Association between the CYP2C9 polymorphism and the drug metabolism phenotype

2004 • 30 citations

Pharmacokinetics of intravenous paracetamol in children and adolescents under major surgery

2005 • 30 citations

Use of Dexmedetomidine in a Pediatric Heart Transplant Patient

2005 • 23 citations

Systematic Overview of the Pharmacological Management of Postherpetic Neuralgia

2004 • 21 citations

Pharmacological strategies in relieving neuropathic pain

2004 • 19 citations

Positive End-expiratory Pressure Increases Exhaled Endogenous Nitric Oxide in Rabbits

1994 • 13 citations

Enhancement of fentanyl antinociception by subeffective doses of nitroparacetamol (NCX-701) in acute nociception and in carrageenan-induced monoarthritis

2005 • 12 citations

Subanalgesic doses of dexketoprofen and HCT-2037 (nitrodexketoprofen) enhance fentanyl antinociception in monoarthritic rats

2004 • 10 citations